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Columbia researchers report first successful pregnancy using AI-guided sperm recovery method

Researchers at the Columbia University Fertility Center reported the first successful pregnancy using an AI-guided method they developed to recover sperm in men with azoospermia, in which ejaculate contains little or no sperm.

31 Oct 2025

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression.

31 Oct 2025

Novel nanoparticles can deliver an immune-stimulating molecule directly to ovarian tumors

Cancer immunotherapy, which uses drugs that stimulate the body's immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn't work well for some tumors, including ovarian cancer.

31 Oct 2025

Study confirms PSA screening improves survival and safety

After 23 years of follow-up, the European Randomized Study of Screening for Prostate Cancer (ERSPC) confirmed a 13% lower prostate cancer mortality with PSA testing and an improved harm–benefit ratio over time. Risk-based screening could sustain mortality gains while reducing overdiagnosis and unnecessary treatment.

30 Oct 2025

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

30 Oct 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

New chemotherapeutic agent shows remarkable efficacy against multiple tumor types

A research team led by the Medical University of Vienna, the HUN-REN Research Centre for Natural Sciences and the Eötvös Loránd University in Budapest has developed a groundbreaking new chemotherapeutic agent, LiPyDau, which shows remarkable efficacy against multiple tumor types in preclinical studies.

30 Oct 2025

Therapeutic potential of Scleromitrion diffusum in gastric cancer treatment

Gastric cancer remains a major global health challenge, characterized by high mortality and limited therapeutic efficacy, especially in advanced stages.

30 Oct 2025

Liver alterations associated with MASLD can directly affect the brain and behavior

A multidisciplinary research team has discovered that liver alterations associated with metabolic dysfunction-associated fatty liver disease (MASLD) can directly cause cognitive and neurological impairments, and that these effects can be reversed by a therapy exclusively targeting the liver.

30 Oct 2025

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Glioblastoma (GBM), the most aggressive primary brain tumor, continues to portend a poor prognosis with median survival under two years, despite standard care involving surgery, radiation, and temozolomide chemotherapy.

30 Oct 2025

Breakthrough could offer a new therapeutic option for stopping diabetes-induced complications

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

30 Oct 2025

WHO’s new pandemic measures may ignore lessons from COVID-19

Analysis of WHO's pandemic response highlights inconsistencies in new guidelines, raising concerns about the evidence base for public health measures.

30 Oct 2025

Diabetes remission possible with GLP-1 drugs, Italian study confirms

In a large real-world Italian cohort, GLP-1 receptor agonist therapy led to measurable rates of type 2 diabetes remission, depending on how remission was defined. The most pragmatic definition (Remission 3) was linked to improved glycemia, weight, and a lower risk of microvascular and cardiovascular events.

29 Oct 2025

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

A systematic review published today in Psychedelics by Mr. James Gattuso and colleagues at the Florey Institute of Neuroscience and Mental Health synthesizes clinical and preclinical evidence on psilocybin's effects on obsessive-compulsive behaviors, revealing consistent therapeutic potential across human patients and validated animal models.

29 Oct 2025

AI indelibly transforms solid tumor drug development

Artificial intelligence (AI) is fundamentally reshaping the landscape of solid tumor (ST) drug development.

29 Oct 2025

Hydroxytyrosol from olives shows new promise as a brain-protective compound

This review highlights hydroxytyrosol's role as a neuroprotective agent, activating key pathways for mental and vascular health through olive-derived compounds.

29 Oct 2025

Wireless retinal implant restores sight in patients blinded by advanced macular degeneration

A new trial shows that a wireless subretinal implant, the PRIMA system, restored central vision in patients with geographic atrophy caused by age-related macular degeneration. After one year, 81% achieved clinically meaningful vision gains and most could read at home using prosthetic vision.

28 Oct 2025

Emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder

In a peer-reviewed article published today in Brain Medicine, a European research team presents a focused review of emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder (OCD).

28 Oct 2025

Exploring the gut-brain-immune axis in neurodegeneration

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), represent a growing global health burden, particularly in aging populations.

28 Oct 2025

Cutting balloon angioplasty proves noninferior to intravascular lithotripsy in treating calcified coronary lesions

Results from the first randomized controlled trial to directly compare the safety and efficacy of cutting balloon (CB) angioplasty to intravascular lithotripsy (IVL) prior to drug-eluting stent (DES) implantation for the treatment of calcified coronary artery disease found CB to be noninferior to IVL.

28 Oct 2025

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Efficacy News and Research

Columbia researchers report first successful pregnancy using AI-guided sperm recovery method

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Novel nanoparticles can deliver an immune-stimulating molecule directly to ovarian tumors

Study confirms PSA screening improves survival and safety

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Advances in diagnosis and management of systemic light chain amyloidosis

New chemotherapeutic agent shows remarkable efficacy against multiple tumor types

Therapeutic potential of Scleromitrion diffusum in gastric cancer treatment

Liver alterations associated with MASLD can directly affect the brain and behavior

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Breakthrough could offer a new therapeutic option for stopping diabetes-induced complications

WHO’s new pandemic measures may ignore lessons from COVID-19

Diabetes remission possible with GLP-1 drugs, Italian study confirms

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

AI indelibly transforms solid tumor drug development

Hydroxytyrosol from olives shows new promise as a brain-protective compound

Wireless retinal implant restores sight in patients blinded by advanced macular degeneration

Emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder

Exploring the gut-brain-immune axis in neurodegeneration

Cutting balloon angioplasty proves noninferior to intravascular lithotripsy in treating calcified coronary lesions

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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