Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Harnessing human brain cells to create biocomputers

JMIR Publications today released a feature story on the emerging field of biocomputing in its News and Perspectives section.

29 May 2026

Experimental vaccine triggers broadly neutralizing HIV antibodies in macaques

For years, researchers have been hoping for vaccines that protect people against not just one strain of HIV, but every strain of the quickly mutating virus.

28 May 2026

Virtual reality navigation deficits predict future brain volume loss

Alzheimer's disease (AD) often begins long before it is clinically recognized, with subtle brain changes emerging years before noticeable memory loss or cognitive decline.

27 May 2026

SLAS celebrates innovative new products, startups and scientific excellence at European conference in Vienna

SLAS, the Society of Laboratory Automation and Screening, after a six-year wait to reschedule the originally planned event in spring of 2020, welcomed 137 exhibitors and more than 1,500 registrants from more than 30 countries at its 2026 Europe Conference and Exhibition, May 19-21.

From Society for Laboratory Automation and Screening (SLAS) 27 May 2026

New oral antiviral drug candidate targets measles and Croup syndrome

A new oral antiviral drug candidate has been developed for the treatment of diseases caused by orthoparamyxoviruses, such as measles and Croup syndrome, according to a study published by researchers in the Center for Translational Antiviral Research at Georgia State University.

22 May 2026

Harvard researchers outline roadmap to solve orphan receptor challenge

A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.

22 May 2026

Graph neural networks accelerate drug discovery for complex bone diseases

Announcing a new publication for Acta Materia Medica journal. Traditional Chinese medicine has shown therapeutic potential in treating osteoarthritis (OA) by regulating inflammation and maintaining cartilage homeostasis.

22 May 2026

AI-created miniproteins show promise for targeting hard-to-treat diseases

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

21 May 2026

Sino Biological launches XPressMAX™ Cell-Free Protein Synthesis Kit, accelerating AI-powered high-throughput antibody drug discovery

Sino Biological, Inc., a global leader in recombinant technology, is proud to announce the launch of its innovative XPressMAX™ Cell-Free Protein Synthesis Kit (Cat#: CFKIT02) , a cutting-edge solution designed to supercharge artificial intelligence (AI)-driven high-throughput screening pipelines for antibody drug discovery.

From Sino Biological Inc. 20 May 2026

Scientists uncover why genome guardian p53 protein is uniquely prone to collapse

The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors.

20 May 2026

Cyclana Bio granted Health Research Authority approval and recruits first patients for clinical observational study in endometriosis

Cyclana Bio, a biotechnology company pioneering tissue-level approaches to women’s health, today announced it has received Health Research Authority (HRA) and Research Ethics Committee (REC) approval for its 500-patient clinical observational study, PEMP (Predicting Endometriosis Mechanisms and Populations).

19 May 2026

Researchers use living human cells on a chip to study memory loss

A University of Bath-led project has secured £500,000 to develop a first-of-its-kind 'organ-on-chip' device that replicates connections between the brain, gut and pancreas.

19 May 2026

How exercise influences cancer cell viability

This interview uncovers how exercise may reduce cancer cell viability, with insights into adipose interactions and innovative 3D culture systems.

From Promega Corporation 15 May 2026

Rocket Science Health validates targeted olfactory-cleft deposition in non-human primates ahead of the 4th Nasal Formulation & Delivery Summit

As the pace of modern drug discovery accelerates, the industry is increasingly recognizing that a breakthrough molecule is only as effective as its ability to reach the target site.

From Hanson Wade Group - 4th Nasal Formulation & Delivery Summit 15 May 2026

Fujitsu and IBM Japan formalize collaboration in healthcare sector

Fujitsu Limited and IBM Japan, Ltd. today announced the formalization of a collaboration within the healthcare domain, building on considerations first announced in September 2025.

From Fujitsu Limited 15 May 2026

New technology reveals how RNA shapes influence protein production and stability

Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called 'sm-PORE-cupine', to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease.

15 May 2026

AI-based generative framework create all-atom models of proteins in motion

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins. When molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

13 May 2026

Dual-pathway protein degradation approach could improve cancer treatment

Targeted protein degradation has become one of the most promising strategies in modern drug discovery, enabling scientists to eliminate disease-causing proteins instead of merely blocking them.

12 May 2026

INDIGO Biosciences expands reporter assay capabilities with new Transrepression Assay Services

INDIGO Biosciences today announced the launch of its Transrepression Assay Services, expanding the company’s cell-based reporter assay capabilities for drug discovery teams studying pathway cross-talk, selective modulation, and transcription factor-mediated gene suppression.

From INDIGO Biosciences, Inc. 11 May 2026

Advanced 3D heart models could transform cardiovascular drug discovery

Cardiovascular disease remains a leading global health burden, yet many preclinical systems still struggle to predict how candidate drugs will perform in the human heart.

10 May 2026