The SkyScan 1276 High-Resolution, Fast In-Vivo Desktop Micro-CT from Bruker Biospin

The SkyScan 1276 is a high performance, stand-alone, fast, desk-top in vivo micro-CT with continuously variable magnification for scanning small laboratory animals (mice, rats, ...) and biological samples. It has an unrivalled combination of high resolution, big image size, possibility for round and spiral (helical) scanning and reconstruction, and low dose imaging. The image field of view (up to 80 mm wide and more than 300 mm long) allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8 µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants. Further, the SkyScan 1276 in vivo micro-CT administers low radiation dose to the animals allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation - induced side effects. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with fastest scanning cycle 3.9 sec.

The SkyScan 1276 allows reconstructing non-invasively any cross section(s) through the animal body with possibilities to convert reconstructed dataset into realistic 3D-image and calculate internal morphological parameters including specific bone structural parameters.

Mouse and Rat Cassettes

The SkyScan 1276 system is supplied with exchangeable animal cassettes that can be used in all Bruker in-vivo imaging instruments such as MRI, micro-PET, micro-SPECT, bio-luminescence, biofluorescence, etc. to collect multimodal information. It allows co-registration of functional and morphological information from the same animal.

Touchscreen Control

The user interface of the SkyScan1276 system is simple and intuitive. The instrument can be controlled from the computer screen and also from the embedded force-sensitive touchscreen, which can be operated by gloved hands. The touchscreen allows selection of scanning protocol, adjusting the animal bed position and control of imaging and scanning. Where multiple scans are started from the touchscreen, the software will automatically save acquired data to separate subfolders with incrementally assigned folder names and dataset file prefixes.


  • 3.9 seconds shortest scanning cycle
  • 2.8 micron highest nominal resolution
  • Spiral (helical) and round scanning