qNMR for Potency Determination - PotencyMR from Bruker

Potency determination, absolute compound purity assessment, identity testing, residual solvent, moisture analysis, relative response factor calculation…. Have you thought about using quantitative NMR (qNMR) as a one-stop solution?

Potency determination by qNMR

Potency determination by qNMR has been shown to be a single point replacement for routine development testing which previously involved several experiments and techniques1 and a superior method for determining the purity of the reference standards2 used for analysis with assured metrological traceability3 such as standards for HPLC.

The downside is that existing qNMR workflows rely on expert knowledge and/or well-trained analysts and detailed protocols.

Bruker’s new potency determination tools streamline this process with a fully automatic workflow from sample submission to report, making it the ideal solution for both experts and non-experts working in a pharmaceutical development environment, where quality is a must.


1. Webster G.F. and Kumar S., Anal Chem, 86, 11474 (2014)
2. Pauli G.F., Godecke T., Jaki B.U. and Lankin D.C., J Nat Prod, 75, 834 (2012)
3. Japanese Pharmacopeia XVII, General Tests and Apparatus, p. 137

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