Cell Biology

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Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

UAB researchers identify potential therapeutic target for ovarian cancer

A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers say in a study published in the journal Oncogenesis.

5 Aug 2021

Researchers use AI to assess metastatic potential of melanoma cells

Using artificial intelligence (AI), researchers from UT Southwestern have developed a way to accurately predict which skin cancers are highly metastatic.

5 Aug 2021

Research explores how cancer cells develop resistance to chemotherapy

Cancer cells sometimes develop resistance to the cytotoxic drugs used in chemotherapy. Figuring out why the treatment isn't working and why it may even defeat its own purpose is therefore important to understand.

5 Aug 2021

Researchers use tiny worm to trace the development of human brain

Researchers at Sinai Health have used a tiny worm to track how an animal’s brain changes throughout its lifetime, shedding new light on how human brains develop.

5 Aug 2021

Bacteriophages named after Norfolk village of Colney could help combat C. difficile infections

Viruses have a menacing reputation for causing disease but some that target bacteria could actually benefit human health.

5 Aug 2021

Study investigates the role of eIF4A3 protein in the growth of cancer cells

For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published today in Science Advances, researchers at Karolinska Institutet in Sweden have investigated the protein eIF4A3 and its role in the growth of cancer cells.

4 Aug 2021

Restoring cholesterol levels could be a new therapeutic approach for diseases linked to TDP-43 protein

Researchers in Singapore have discovered that brain cells cannot maintain the cholesterol-rich myelin sheath that protects and insulates neurons in the absence of a protein called TDP-43.

4 Aug 2021

Study offers genetic insights into the underlying biology of reproductive aging

The age at which women go through menopause is critical for fertility and impacts healthy ageing in women, but reproductive ageing has been difficult for scientists to study and insights into the underlying biology are limited.

4 Aug 2021

Scientists identify new therapeutic target for several aggressive cancers

A protein in tumor cells could be targeted to treat some types of aggressive cancer including brain, blood, skin, and kidney, new research has shown.

4 Aug 2021

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells.

4 Aug 2021

Feinstein Institutes awarded $2.9 million NIH funding for polygenic embryo selection studies

Genetic testing and selection of embryos generated from in vitro fertilization have given rise to the controversial “designer baby” debate.

4 Aug 2021

Surplus sugar may cause our cellular powerplants to become less efficient, finds study

The average American eats roughly 22 teaspoons of added sugar a day -; more than three times the recommended amount for women and more than double the recommended amount for men.

3 Aug 2021

Start codon disruption with CRISPR-Cas9 gene editing prevents Fuchs’ corneal dystrophy in mice

In a new study, researchers at the University of Oregon's Phil and Penny Knight Campus for Accelerating Scientific Impact used start codon disruption with CRISPR-Cas9 gene editing to prevent Fuchs' corneal dystrophy in mice.

3 Aug 2021

Comprehensive review: Nanomaterial-based delivery vehicles for cancer vaccine development

Over the years, significant advancements in cancer research have led us to the next step in cancer therapy – vaccines for cancer! However, the direct use of these vaccines in the affected individuals have often failed to bring about desired anti-tumor effects.

3 Aug 2021

Lipid blast shield protects natural killer cells and also some cancer cells

A newly discovered fat 'shield' that prevents natural killer cells from being destroyed by their own deadly biological weapons also allows some cancer cells to evade an immune system attack, a study at Columbia University has found.

3 Aug 2021

Researchers discover brain's switching system used in information processing and storing of memories

A team of scientists has uncovered a system in the brain used in the processing of information and in the storing of memories--akin to how railroad switches control a train's destination. The findings offer new insights into how the brain functions.

3 Aug 2021

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Treating mice that have a Parkinson's disease-causing mutation with a small molecule compound restores the removal of damaged mitochondria from their brain cells, shows a study published today in eLife.

3 Aug 2021

Study reveals novel mechanism underlying infantile spasms-associated learning deficits

Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry.

3 Aug 2021

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

Ovarian cancer devastates more than 20,000 women in the U.S. every year, due in part to its tendency to evade detection and present after metastatic spread. A key element to slowing metastasis is understanding the mechanisms of how tumor cells invade tissues.

3 Aug 2021

Cell Biology

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

UAB researchers identify potential therapeutic target for ovarian cancer

Researchers use AI to assess metastatic potential of melanoma cells

Research explores how cancer cells develop resistance to chemotherapy

Researchers use tiny worm to trace the development of human brain

Bacteriophages named after Norfolk village of Colney could help combat C. difficile infections

Study investigates the role of eIF4A3 protein in the growth of cancer cells

Restoring cholesterol levels could be a new therapeutic approach for diseases linked to TDP-43 protein

Study offers genetic insights into the underlying biology of reproductive aging

Scientists identify new therapeutic target for several aggressive cancers

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

Feinstein Institutes awarded $2.9 million NIH funding for polygenic embryo selection studies

Surplus sugar may cause our cellular powerplants to become less efficient, finds study

Start codon disruption with CRISPR-Cas9 gene editing prevents Fuchs’ corneal dystrophy in mice

Comprehensive review: Nanomaterial-based delivery vehicles for cancer vaccine development

Lipid blast shield protects natural killer cells and also some cancer cells

Researchers discover brain's switching system used in information processing and storing of memories

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Study reveals novel mechanism underlying infantile spasms-associated learning deficits

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

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