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Menarini Group signs licensing deal with Insilico for promising cancer treatment

The Menarini Group ("Menarini"), a leading international pharmaceutical and diagnostics company, and Stemline Therapeutics, Inc. ("Stemline"), a wholly-owned subsidiary of the Menarini Group focused on bringing transformational oncology treatments to cancer patients, and Insilico Medicine ("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, today announced that the companies have entered into an exclusive licensing agreement granting Stemline the global rights to develop and commercialize a preclinical small molecule targeting high unmet needs in oncology.

10 Jan 2025

Early diagnosis of Dementia with Lewy Bodies could be improved by cognitive profiling

Cognitive profiles for early diagnosis of Dementia with Lewy bodies (DLB) have been outlined in a new study, out today in Alzheimer's & Dementia.

10 Jan 2025

Research explores molecular dynamics of CAR T cells in cancer treatment

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer.

10 Jan 2025

Medicare Advantage leads to lower cancer drug costs in colorectal cancer

A new study examining the use of high-cost drugs among patients with colorectal cancer and non-small cell lung cancer found those insured through Medicare Advantage received less expensive cancer drugs compared to others on Traditional Medicare.

10 Jan 2025

New study highlights gender differences in diagnosing heart condition

Women may be missing a diagnosis of a potentially deadly heart condition due to guidelines that don't account for natural differences in sex and body size, according to a new study led by UCL (University College London) researchers.

10 Jan 2025

Researchers identify causes of grammatical tense impairments in aphasia

An international team of researchers, including scientists from the HSE Centre for Language and Brain, has identified the causes of impairments in expressing grammatical tense in people with aphasia.

10 Jan 2025

Red light exposure may help reduce risk of blood clots

Humans and mice exposed to long-wavelength red light had lower rates of blood clots that can cause heart attacks, lung damage and strokes, according to research led by University of Pittsburgh School of Medicine and UPMC surgeon-scientists and published today in the Journal of Thrombosis and Haemostasis.

10 Jan 2025

AI could revolutionize cervical cancer screening and detection

Cervical cancer remains a major health threat for women globally, with the highest incidence in developing nations.

10 Jan 2025

Brain maturation delays linked to unhealthy eating behaviors in youth

More than half of 23-year-olds in a European study show restrictive, emotional or uncontrolled eating behaviors, according to new research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.

10 Jan 2025

Breakthrough microscopy technique reveals how antibodies target cancer cells

In blood cancers such as chronic lymphocytic leukaemia, B cells of the immune system multiply uncontrollably.

10 Jan 2025

Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

New biomaterial could redefine recovery from brain and central nervous system injuries

A new electrically active transplantable material that can help to regrow cells in the brain and spinal cord could redefine the recovery prospects of patients who sustain life-altering injuries or suffer from neurodegenerative diseases.

10 Jan 2025

Analysis highlights high TBI death rates among older adults and men

A new analysis of U.S. mortality data reveals the disproportionate impact of traumatic brain injuries (TBI) on older adults, males and certain racial and ethnic groups.

10 Jan 2025

Elderberry juice shows promise in boosting gut health and combating obesity

Elderberry juice rich in anthocyanins boosts glucose regulation and fat metabolism, with significant effects on gut microbiota in overweight adults.

10 Jan 2025

Sex-specific mitochondrial marker deficiencies linked to early cognitive dysfunction in Alzheimer’s disease

Research reveals sex-specific free-carnitine deficiency in women with cognitive impairment, linking mitochondrial metabolism to Alzheimer's disease progression.

10 Jan 2025

New therapeutic target could boost CAR T-cell therapy success in solid tumors

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, "TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids".

10 Jan 2025

RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025