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Oral GLP-1 drug orforglipron achieves significant weight loss in global trial

Patients taking an experimental oral GLP-1 drug lost significant weight and improved their heart and metabolic risk factors in a large, international, phase III clinical trial led by investigators at Weill Cornell Medicine, McMaster University, York University and other institutions

18 Sep 2025

New trial demonstrates efficacy of tirzepatide in children and adolescents with type 2 diabetes

New research shows that that the diabetes/obesity medication tirzepatide can cause clinically meaningful improvements in blood sugar control and weight loss in children and adolescents with type 2 diabetes aged 10-17 years whose diabetes and weight are inadequately controlled with an existing treatment regimen of metformin, insulin, or both.

18 Sep 2025

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

A large U.S. Department of Veterans Affairs cohort study found that Nicotinamide use was associated with a 14% lower risk of new keratinocyte skin cancers, driven by a 22% reduction in cSCC and no reduction in BCC. The strongest benefit (56% lower risk) appeared when nicotinamide was started after a patient’s first skin cancer, with diminishing returns after multiple cancers.

18 Sep 2025

PANoptosis emerges as a promising strategy against liver cancer

Liver cancer, particularly hepatocellular carcinoma (HCC), remains one of the deadliest cancers, driven by high recurrence and resistance to therapy.

18 Sep 2025

Daily orforglipron GLP-1 pill achieves over 11% weight loss in global obesity trial

In a phase 3 trial, once-daily oral orforglipron induced significant, dose-dependent weight loss over 72 weeks in adults with obesity but no diabetes. It also improved multiple cardiometabolic markers with a safety profile similar to other GLP-1 receptor agonists.

18 Sep 2025

Digital twin of lung cancer cell offers new insights into tumor growth and treatment

An enhanced computer model is now helping to provide fresh insights into cancer-cell growth and how it can be stopped. The digital cell model represents another step towards individualized cancer treatment.

18 Sep 2025

Evening meals hold the key to morning glucose control in prediabetes

The way glucose is regulated at night plays a key role in fasting glucose levels the next morning, when blood sugar is expected to be at its lowest.

18 Sep 2025

Nursing researchers explore new ways to improve the quality of methadone treatment

Researchers at the University of Arizona College of Nursing are testing an intervention to reduce staff stress and improve methadone patient treatment retention for opioid use disorder thanks to a $4.5 million grant from the National Institute on Drug Abuse, a division of the National Institutes of Health.

18 Sep 2025

Clinical trial reveals encouraging results for apitegromab in spinal muscular atrophy

A new clinical trial has revealed encouraging results for a muscle-targeting therapy aimed at improving motor function in children and adolescents with spinal muscular atrophy, according to a study published in The Lancet Neurology.

18 Sep 2025

Muscle hormone FGF21 linked to longer survival in ALS

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 9, 2025, titled "The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity."

18 Sep 2025

POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

Idiopathic pulmonary fibrosis is a potentially fatal disease currently without treatment, in which lung tissue develops scarring and becomes stiff, making breathing increasingly difficult over time.

18 Sep 2025

Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

Research led by The Ohio State University Wexner Medical Center and College of Medicine explores the ways brain cells communicate, revealing fresh insight into the progression of Alzheimer's disease.

18 Sep 2025

Cholesterol control improves but cardiovascular disease still increases in Mexico

Despite improved statin use and cholesterol control, cardiovascular disease risk rose in Mexico between 2016 and 2023, according to a study being presented at ACC Latin America 2025 that used region-specific tools to more accurately predict the local disease burden.

18 Sep 2025

Music therapy improves patient experience and outcomes in the cardiac ICU

Music therapy could significantly reduce heart rate, blood pressure and patient–ventilator asynchronies for patients admitted to the cardiac intensive care unit (ICU), according to research being presented at ACC Latin America 2025 taking place September 18-20 in Mexico City.

18 Sep 2025

New study uncovers why dispersed glioblastoma cells are more dangerous

A new study, led by researchers at Sylvester Comprehensive Cancer Center part of the University of Miami Miller School of Medicine, captured details of glioblastoma that had never before been seen and revealed a surprise finding: Glioblastoma cells that "cluster" together with other cells of the same type are less deadly than those that disperse from these clusters.

18 Sep 2025

University of Houston co-leads national study on atropine eyedrops for nearsightedness prevention

The University of Houston is co-leading a national study, the first of its kind in the United States, exploring whether atropine eyedrops can delay the onset of nearsightedness in young children and lessen its progression over a lifetime, a project with potential to shape future standards in vision care.

18 Sep 2025

International societies release new guideline for 18F-flurpiridaz PET myocardial perfusion imaging

The Society of Nuclear Medicine and Molecular Imaging (SNMMI), American Society of Nuclear Cardiology (ASNC), European Association of Nuclear Medicine (EANM), and American College of Nuclear Medicine (ACNM) have issued a new clinical guideline for 18F-flurpiridaz PET myocardial perfusion imaging (MPI) and blood flow quantitation.

18 Sep 2025

Oral microbiome linked to threefold higher pancreatic cancer risk

Twenty-seven species of bacteria and fungi among the hundreds that live in people's mouths have been collectively tied to a 3.5 times greater risk of developing pancreatic cancer, a study led by NYU Langone Health and its Perlmutter Cancer Center shows.

18 Sep 2025

Mediterranean diet may protect gums by reducing severe periodontitis

This study reveals that the Mediterranean diet may protect against periodontitis, highlighting its benefits for oral health and inflammation reduction.

18 Sep 2025

Researchers identify seizure-associated depolarization as cause of post-ictal symptoms

People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) have identified a neurobiological mechanism that could be responsible for this so-called post-ictal wandering and potentially other postictal symptoms.

18 Sep 2025

Medical Condition News

Oral GLP-1 drug orforglipron achieves significant weight loss in global trial

New trial demonstrates efficacy of tirzepatide in children and adolescents with type 2 diabetes

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

PANoptosis emerges as a promising strategy against liver cancer

Daily orforglipron GLP-1 pill achieves over 11% weight loss in global obesity trial

Digital twin of lung cancer cell offers new insights into tumor growth and treatment

Evening meals hold the key to morning glucose control in prediabetes

Nursing researchers explore new ways to improve the quality of methadone treatment

Clinical trial reveals encouraging results for apitegromab in spinal muscular atrophy

Muscle hormone FGF21 linked to longer survival in ALS

POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

Cholesterol control improves but cardiovascular disease still increases in Mexico

Music therapy improves patient experience and outcomes in the cardiac ICU

New study uncovers why dispersed glioblastoma cells are more dangerous

University of Houston co-leads national study on atropine eyedrops for nearsightedness prevention

International societies release new guideline for 18F-flurpiridaz PET myocardial perfusion imaging

Oral microbiome linked to threefold higher pancreatic cancer risk

Mediterranean diet may protect gums by reducing severe periodontitis

Researchers identify seizure-associated depolarization as cause of post-ictal symptoms

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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