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Baylor study sheds light on role of CDKL1 and CDKL2 in neurodevelopmental disorders

CDKL5, one of the five members of the CDKL family of genes, is important for proper neurodevelopment and associated with seizures.

14 Mar 2025

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

14 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Fighting cancer, inflammation and unlocking dementia diagnostics

In recognition of their discovery of one of our immune system’s foundations, physician Andrea Ablasser, virologist Glen Barber and biochemist Zhijian J. Chen will be awarded the Paul Ehrlich and Ludwig Darmstaedter Prize 2025, endowed with €120,000, in Frankfurt’s Paulskirche today.

14 Mar 2025

Over 40,000 new gut microbes discovered in African populations

More than 40,000 previously unknown gut microbes in African populations could completely change how medicines work for millions of people, according to scientists.

14 Mar 2025

Long-COVID symptoms persist for two years in over half of cases

23% of people infected with SARS-CoV-2 between 2021 and 2023 developed long-COVID, and in more than half of them the symptoms persisted for two years.

14 Mar 2025

Study links inflammation pathways to changes in bone mineral density

In one of the first studies of its kind, a team of researchers from Keck School of Medicine of USC has found that proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time.

14 Mar 2025

Bioenergetic age could predict Alzheimer's disease risk

A person's "bioenergetic age"-or how youthfully their cells generate energy-might be a key indicator of whether they're at risk of developing Alzheimer's disease, new research from Weill Cornell Medicine shows.

14 Mar 2025

Long-term study shows knee replacements last lifetime for active young adults

A 40-year study by Hospital for Special Surgery (HSS) researchers has found that active young adults who underwent total knee replacement were unlikely to require knee replacement revision in their lifetime, according to a new study shared today in a podium presentation at the American Academy of Orthopaedic Surgeons 2025 Annual Meeting.

14 Mar 2025

New method enhances precision in monitoring brain activity during deep brain stimulation

Mayo Clinic researchers have found a new way to more precisely detect and monitor brain cell activity during deep brain stimulation, a common treatment for movement disorders such as Parkinson's disease and tremor.

14 Mar 2025

Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases

A research team from the Medical University of Vienna has made further progress in the treatment of intestinal inflammation.

14 Mar 2025

Malnutrition in heart failure patients associated with diminished GDMT prescription rates

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at identifying crucial gaps in guideline-directed medical therapy (GDMT) application among malnourished patients at Beijing Anzhen Hospital.

14 Mar 2025

National survey reveals high public interest in medically tailored food programs

Researchers have conducted the first national survey on public awareness and perceptions of food, health, and Food is Medicine programs.

14 Mar 2025

NIH researchers define topical steroid withdrawal diagnostic criteria

Researchers at the National Institutes of Health (NIH) have determined that dermatitis resulting from topical steroid withdrawal (TSW) is distinct from eczema and is caused by an excess of an essential chemical compound in the body.

14 Mar 2025

Combination of RAS inhibition and immunotherapy provides breakthrough for pancreatic cancer

Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept pancreatic cancer at bay in preclinical models for significantly longer than the same targeted therapy by itself, according to researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

14 Mar 2025

Pitt study uncovers a novel trigger of deadly form of ovarian cancer

Researchers at the University of Pittsburgh have identified a novel trigger of a deadly form of ovarian cancer: a subset of progenitor cells that reside in fallopian tube supportive tissue, or stroma.

14 Mar 2025

New research aims to unravel genetic mysteries of polycystic kidney disease

Polycystic kidney disease (PKD), a family of genetic disorders that causes clusters of cysts to form on the kidney, is among the most common genetic disorders, affecting some 500,000 people in the United States.

14 Mar 2025

Maternal high-fat diets linked to liver stress in unborn babies

When mothers eat a diet high in fat and sugars, their unborn babies can develop liver stress that continues into early life.

14 Mar 2025

New therapeutic approach shows promise for pediatric high-grade gliomas

Brain tumors remain the most common cause of death from childhood cancer. Paediatric high-grade gliomas (pHGG) in particular are a mostly fatal disease group with a median survival time of less than 18 months after diagnosis and limited treatment options.

14 Mar 2025

Social advantage reduces risk of age-related diseases and slows aging

People with favorable socioeconomic conditions, such as high incomes or education levels, face a reduced risk of age-related diseases and show fewer signs of biological aging than peers of the same age, finds a new study led by University College London (UCL) researchers.

14 Mar 2025