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New study explores obecabtagene autoleucel for adults with hard-to-treat leukemia

FELIX study results reveal obe-cel's potential in relapsed B-cell ALL, achieving 77% remission with low severe toxicity, enhancing CAR T-cell therapy outcomes.

2 Dec 2024

Natural proteins may offer new way to treat covid-19 and autoimmune disorders

Some people naturally have higher levels of proteins that protect them from covid-19. New studies at Umeå University of our immune system may pave the way for more personalized treatments of both covid-19 and autoimmune disorders.

2 Dec 2024

ARMC5 regulates saturated and unsaturated fatty acid levels in fat cells

Researchers at Osaka University identified a degradation factor for SREBP1 as essential for maintaining the balance of saturated and unsaturated fatty acids in adipose tissue.

2 Dec 2024

Gut transit time and pH shape microbiome individuality and dietary responses

Scientists reveal gut transit time and pH as key drivers of microbiome and metabolic individuality, paving the way for personalized dietary strategies.

1 Dec 2024

Can beef fit in a heart-healthy diet? Review provides new insights

A systematic review suggests unprocessed beef has minimal impact on cardiovascular health markers.

1 Dec 2024

Men face sharper brain aging from obesity and heart risks

Obesity and cardiovascular risk factors accelerate brain volume loss, with males experiencing earlier and more significant impacts, highlighting the importance of early interventions to prevent neurodegeneration.

1 Dec 2024

Neural connectivity predicts deep brain stimulation success in essential tremor

Study unveils how specific cortico-thalamic connectivity patterns influence essential tremor suppression with deep brain stimulation (DBS). It highlights the contralateral thalamus as a pivotal driver of tremor modulation and potential pathways for enhanced intervention strategies.

1 Dec 2024

Fibroblastic reticular cells power immune defenses in lung cancer

Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, clustering, and activation. This study highlights FRCs' potential as therapeutic targets to boost anti-tumor immunity in non-small cell lung cancer (NSCLC).

1 Dec 2024

Quabodepistat combo shows promise for safer, faster tuberculosis treatment

Study highlights the safety and early bactericidal activity of quabodepistat when combined with delamanid, bedaquiline, or both, offering potential for shorter and more tolerable tuberculosis treatment regimens.

1 Dec 2024

Systemic barriers hold back diverse talent in academic medicine

A JAMA Network Open study reveals persistent inequities in academic medicine, where women and racial/ethnic minority physicians face significant barriers to promotions. These disparities, rooted in systemic biases, highlight the urgent need for reforms in recruitment and evaluation processes.

1 Dec 2024

Reinstating masking curbs hospital viral outbreaks, study confirms

Researchers investigate how changes in hospital policies for SARS-CoV-2 testing and masking have influenced hospital-acquired respiratory viral infections.

1 Dec 2024

Ultra-processed foods increase active psoriasis risk, study shows

This study highlights a significant link between high ultra-processed food (UPF) consumption and active psoriasis, independent of BMI and other factors. The findings emphasize UPFs' contribution to proinflammatory pathways in individuals with this chronic skin condition.

1 Dec 2024

Warmer temperatures weaken immune systems in wild capuchin monkeys

The immune performance of wild capuchin monkeys declines when the animals experience higher temperatures, and younger monkeys seem to be particularly vulnerable to heat, according to a University of Michigan study.

29 Nov 2024

KIT’s 3ROCKIT 3R Center works towards developing methods to replace animal testing

In future medicine, personalized computer models, so-called Virtual Human Twins, could help in the planning of individual therapies.

29 Nov 2024

Nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication

Researchers evaluate changes in alcohol use after initiating antiobesity medication.

29 Nov 2024

RNA enzyme found key to heart cell energy shift after birth

Researchers investigate the influence of Mettl1 on energy metabolism and the maturation of heart cells after birth.

29 Nov 2024

Scientists identify drug-resistant bone marrow cells linked to poor outcomes in fast-growing leukemia

Researchers explore treatment resistance and relapse in T-cell acute lymphoblastic leukemia.

29 Nov 2024

STAG2 loss linked to increased aggression in Ewing sarcoma

Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare – 9 to 10 cases per million inhabitants per year – but it is very aggressive. 25% of patients do not respond well to regular therapy and they often experience relapses.

29 Nov 2024

UQ researchers move closer to developing topical cream for skin cancers in transplant patients

A topical cream to help prevent and treat skin cancers in organ transplant patients is a step closer to development.

28 Nov 2024

New dropletronic devices could transform bioengineering and medicine

Oxford University researchers have made a significant step towards realizing a form of 'biological electricity' that could be used in a variety of bioengineering and biomedical applications, including communication with living human cells.

28 Nov 2024