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Researchers uncover molecular mechanisms driving RNA processing defects in Huntington's disease

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal lobar dementia and Alzheimer's disease.

8 Jan 2025

Mutation in ASXL1 gene triggers chain reaction leading to blood disorders

Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production.

8 Jan 2025

New AI system aims to improve real-world application of clinical trial results

A new study led by Winship Cancer Institute of Emory University and Abramson Cancer Center of University of Pennsylvania researchers demonstrates that a first-of-its-kind platform using artificial intelligence (AI) could help clinicians and patients assess whether and how much an individual patient may benefit from a particular therapy being tested in a clinical trial.

8 Jan 2025

3D printed bone scaffolds successfully used to rebuild jawbone

Clinicians have successfully used custom-made 3D printed bone scaffolds, printed on-site at The University of Queensland, to rebuild part of a man's jawbone.

8 Jan 2025

Childhood stress impacts epigenetic profile of sperm and brain development

Childhood stress can impact the epigenetic profile of sperm. These results may also have practical implications for future generations through epigenetic inheritance, as many of the observed epigenetic associations are related to brain development.

8 Jan 2025

Can green tea help prevent cognitive decline?

Higher green tea consumption significantly reduces cerebral white matter lesions in older adults, offering potential protective effects against cognitive decline.

8 Jan 2025

Blood test could help track Alzheimer's disease progression and severity

Declining blood levels of two molecules that occur naturally in the body track closely with worsening Alzheimer's disease, particularly in women.

8 Jan 2025

Brown adipose tissue could enhance exercise performance and longevity

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 18, 2024, entitled "Brown adipose tissue enhances exercise performance and healthful longevity."

8 Jan 2025

Elderberry juice improves metabolic health and weight management

Elderberry juice may be a potent tool for weight management and enhancing metabolic health, according to a recent Washington State University-led study.

8 Jan 2025

UCD researchers discover gene mutation linked to vision problems in zebrafish

Researchers in University College Dublin (UCD) have discovered that a mutation in a gene called emc1 causes major vision problems in zebrafish.

8 Jan 2025

Age-related decline in cardiac conduction system regeneration increases arrhythmia risk after heart attack

Study uncovers the impact of myocardial infarction on the cardiac conduction system, revealing insights into arrhythmogenesis and potential therapeutic targets.

8 Jan 2025

Single-dose malaria vaccine offers unprecedented 90% protection

Results from the malaria vaccine trial indicate that GA2 immunization provides significant protection, paving the way for more effective vaccination strategies.

8 Jan 2025

Study links glymphatic system damage to vascular dementia

A new study from the Keck School of Medicine of USC has tested a biomarker linked to vascular dementia across four separate groups and proposed an explanation for how cognitive impairment arises.

8 Jan 2025

These veggie-packed brownies might just be the game-changer your diet needs!

Researchers modify a traditional brownie recipe by replacing butter with plant-based ingredients.

8 Jan 2025

Multilingualism boosts executive function and reduces core symptoms in children with autism

A study reveals that multilingual exposure boosts executive function and perspective-taking in children with autism, highlighting its potential benefits.

8 Jan 2025

Extended Paxlovid courses show mixed results for long COVID symptoms

A study indicates that longer Paxlovid treatments could improve long COVID symptoms in some patients, highlighting the need for tailored antiviral strategies.

8 Jan 2025

New research reframes the debate on drug development costs

The typical cost of developing new medications may not be as high as generally believed, with a few ultra-costly medications skewing public discussions about the cost of pharmaceutical research and development, according to a new RAND study.

8 Jan 2025

AI-designed drug shows promise for inflammatory bowel disease

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announces positive results from two Phase I studies in Australia and China of ISM5411, a novel gut-restricted and PHD specific Inhibitor designed and optimized with the support of Insilico's Chemistry42 commercially-available generative reinforcement learning platform, for Inflammatory Bowel Disease (IBD).

8 Jan 2025

Scientists discover new target for treating aggressive brain cancer

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer.

8 Jan 2025

Study reveals shocking delays in child mental health care

Children and young people with high levels of mental health needs are struggling to receive the help they need, or to have their difficulties recognized, according to a new study.

8 Jan 2025