Ulcerative Colitis

Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

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Latest Ulcerative Colitis News and Research

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New clinical trial to test possible therapeutics for COVID-19 in hospitalized patients

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Patient support program for painful conditions may also help avoid use of risky opioids

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Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

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Artificial super stool may be a game-changer in the treatment of chronic gut infections

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

Defects in specific goblet cells may be a factor contributing to ulcerative colitis

Defects in specific goblet cells may be a factor contributing to ulcerative colitis

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Leaky gut and microbial dysbiosis could contribute to cytokine storm in severely ill COVID-19 cases

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Infliximab may hinder the effectiveness of some COVID-19 vaccines

New study may shed light on inflammatory bowel disease

New study may shed light on inflammatory bowel disease

DNMT3a plays a key role in regulating HSC responses to infections

DNMT3a plays a key role in regulating HSC responses to infections

Whole-genome study of IBD in African Americans reveals a different genetic risk landscape

Whole-genome study of IBD in African Americans reveals a different genetic risk landscape

Nanotherapy shows potential for treating severe Crohn's disease

Nanotherapy shows potential for treating severe Crohn's disease

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Inherited genetic variation may affect the response to cancer immunotherapy

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Novel method instructs immune cells to help repair damaged tissues in the intestine

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New diagnostic imaging tool measures naturally occurring enzymes in the gastrointestinal tract

New partnership to develop test for predicting disease course in pediatric Crohn's patients

New partnership to develop test for predicting disease course in pediatric Crohn's patients

Researchers develop a novel, patient-derived model of ulcerative colitis

Researchers develop a novel, patient-derived model of ulcerative colitis

Polygenic risk scores from multi-population data could improve IBD predictions

Polygenic risk scores from multi-population data could improve IBD predictions

Researchers demonstrate potential preventive treatment for Crohn's disease

Researchers demonstrate potential preventive treatment for Crohn's disease

Researchers pinpoint key factors to ensure successful fecal microbiota transplants

Researchers pinpoint key factors to ensure successful fecal microbiota transplants