Ulcerative Colitis

Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

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Latest Ulcerative Colitis News and Research

Study provides insights into how microbes protect gut health in early life

Study provides insights into how microbes protect gut health in early life

Unraveling gut-to-brain communication paves way for targeted treatments

Unraveling gut-to-brain communication paves way for targeted treatments

Mount Sinai researchers reveal innovative mechanisms to predict and prevent Crohn's disease

Mount Sinai researchers reveal innovative mechanisms to predict and prevent Crohn's disease

FDA approves immune-modulating therapy for treatment of multiple sclerosis

FDA approves immune-modulating therapy for treatment of multiple sclerosis

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Fecal Microbiota Transplants highly successful in treating patients with C.diff infection

Fecal Microbiota Transplants highly successful in treating patients with C.diff infection

Immunosuppressive therapy does not increase risk of vulvar or vaginal cancer in women with IBD

Immunosuppressive therapy does not increase risk of vulvar or vaginal cancer in women with IBD

Aging and competition for nutrients determine changes in gut bacteria

Aging and competition for nutrients determine changes in gut bacteria

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

New AI system can evaluate endoscopic findings of ulcerative colitis with accuracy

New AI system can evaluate endoscopic findings of ulcerative colitis with accuracy

Ulcerative colitis and a missing microbe in the gut

Ulcerative colitis and a missing microbe in the gut

Metformin could help leaky gut

Metformin could help leaky gut

Georgia State researcher receives $1.67 million federal grant to study gut immunity

Georgia State researcher receives $1.67 million federal grant to study gut immunity

Regenerative biology could be used to restore mucus production, shows study

Regenerative biology could be used to restore mucus production, shows study

A new study reveals the secrets of mucus production that could be applied to cancer biology

A new study reveals the secrets of mucus production that could be applied to cancer biology

Study reveals new mechanism involved in the pathogenesis of IBD

Study reveals new mechanism involved in the pathogenesis of IBD

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Scientists develop an approach to vaccinate against gut inflammation

Scientists develop an approach to vaccinate against gut inflammation

Immune cells repair damaged gut in children with IBD

Immune cells repair damaged gut in children with IBD

Researchers test vaccine strategy for chronic inflammatory diseases

Researchers test vaccine strategy for chronic inflammatory diseases