Ulcerative Colitis

Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

Read More

Overview

Feature Articles

Latest Ulcerative Colitis News and Research

Antibiotic use could explain the growth in inflammatory bowel disease in older people

Antibiotic use could explain the growth in inflammatory bowel disease in older people

Report highlights the need for an office to support autoimmune disease research across NIH institutes

Report highlights the need for an office to support autoimmune disease research across NIH institutes

Predicative marker and potential treatment option for IBD discovered

Predicative marker and potential treatment option for IBD discovered

Hydrogen sulfide production in the gut is based on animal- or plant-based diet, study finds

Hydrogen sulfide production in the gut is based on animal- or plant-based diet, study finds

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Improving Medical Communication through Social Media

Improving Medical Communication through Social Media

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

Researchers develop novel technique to identify relationships among medical concepts

Researchers develop novel technique to identify relationships among medical concepts

New insight into lymphoid cell maturity could pave the way for more effective IBD treatments

New insight into lymphoid cell maturity could pave the way for more effective IBD treatments

Vaccines safely protect IBD patients from COVID-19

Vaccines safely protect IBD patients from COVID-19

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Research provides a roadmap for new therapies to treat chorioamnionitis

Research provides a roadmap for new therapies to treat chorioamnionitis

Association between the COVID-19 pandemic and inflammatory bowel disease presentation in New York City

Association between the COVID-19 pandemic and inflammatory bowel disease presentation in New York City

People who consume sugar for extended periods have increased risk of autoimmune disease

People who consume sugar for extended periods have increased risk of autoimmune disease

Toxin-producing yeast strains may damage the gut of patients with inflammatory bowel disease

Toxin-producing yeast strains may damage the gut of patients with inflammatory bowel disease

New insight into how gut bacteria work to counter intestinal inflammation

New insight into how gut bacteria work to counter intestinal inflammation

Research finds link between long-term exposure to air pollution and autoimmune disease risk

Research finds link between long-term exposure to air pollution and autoimmune disease risk

New computational biology method deciphers gut microbiome ‘chatter’ to fight IBD

New computational biology method deciphers gut microbiome ‘chatter’ to fight IBD

T cell responses in inflammatory bowel disease patients on immune-modifying agents after mRNA COVID-19 vaccination

T cell responses in inflammatory bowel disease patients on immune-modifying agents after mRNA COVID-19 vaccination

Heart attack survivors may have a lower risk of Parkinson's disease

Heart attack survivors may have a lower risk of Parkinson's disease