Ulcerative Colitis

Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

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Latest Ulcerative Colitis News and Research

New computational model can help determine drug viability

New computational model can help determine drug viability

Finding the right treatment for people with IBD may soon become easier

Finding the right treatment for people with IBD may soon become easier

Study may lead to more effective treatments for chronic intestinal inflammation

Study may lead to more effective treatments for chronic intestinal inflammation

Chronic inflammation associated with IBD disrupts tissue structure of the colon, study finds

Chronic inflammation associated with IBD disrupts tissue structure of the colon, study finds

First microbiome study of Irish Travelers provides important new health insights

First microbiome study of Irish Travelers provides important new health insights

High fiber diet may improve the quality of life for patients with ulcerative colitis

High fiber diet may improve the quality of life for patients with ulcerative colitis

Irritable bowel disease heightens the risk of dementia

Irritable bowel disease heightens the risk of dementia

Defective maintenance puts intestinal health in danger

Defective maintenance puts intestinal health in danger

Anti-TNF drug preserves beta-cell function in newly diagnosed pediatric patients with Type 1 diabetes

Anti-TNF drug preserves beta-cell function in newly diagnosed pediatric patients with Type 1 diabetes

Probiotics are not recommended for most digestive conditions

Probiotics are not recommended for most digestive conditions

New research focuses on protein-coding gene's role in inflammatory bowel disease

New research focuses on protein-coding gene's role in inflammatory bowel disease

Variations in genome’s 'dark matter' region can make patients susceptible to inflammatory diseases

Variations in genome’s 'dark matter' region can make patients susceptible to inflammatory diseases

Researchers establish link between inflammatory bowel disease and celiac disease

Researchers establish link between inflammatory bowel disease and celiac disease

Therapeutic peptides that can be taken orally

Therapeutic peptides that can be taken orally

Some foods common in diets of adults with inflammatory bowel disease

Some foods common in diets of adults with inflammatory bowel disease

AGA publishes new COVID-19 guidance for gastroenterologists treating patients with IBD

AGA publishes new COVID-19 guidance for gastroenterologists treating patients with IBD

Researchers pinpoint genetic variation responsible for development of IBD

Researchers pinpoint genetic variation responsible for development of IBD

Study compares health of pregnant and non-pregnant women with IBD

Study compares health of pregnant and non-pregnant women with IBD

Study provides insights into how microbes protect gut health in early life

Study provides insights into how microbes protect gut health in early life

Unraveling gut-to-brain communication paves way for targeted treatments

Unraveling gut-to-brain communication paves way for targeted treatments