Ulcerative Colitis

Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

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Overview

Feature Articles

Latest Ulcerative Colitis News and Research

Study reveals disparities in healthcare utilization among racial and ethnic groups with IBD

Study reveals disparities in healthcare utilization among racial and ethnic groups with IBD

Machine learning identifies key comorbidities predicting premature death in IBD patients

Machine learning identifies key comorbidities predicting premature death in IBD patients

Epstein-Barr virus triggers inflammatory cell death in ulcerative colitis

Epstein-Barr virus triggers inflammatory cell death in ulcerative colitis

Machine learning helps predict early mortality in IBD patients

Machine learning helps predict early mortality in IBD patients

Plant-based diets and IBD

Plant-based diets and IBD

Experts release new guidelines on JAK inhibitors for chronic inflammatory diseases

Experts release new guidelines on JAK inhibitors for chronic inflammatory diseases

Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases

Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases

Restoring gut health in ulcerative colitis through microbiome-based therapy

Restoring gut health in ulcerative colitis through microbiome-based therapy

Eating ultra-processed foods harms your gut—here’s how inflammation takes hold

Eating ultra-processed foods harms your gut—here’s how inflammation takes hold

Nationally recognized gastroenterologist joins NYU Langone to lead Pediatric IBD Program

Nationally recognized gastroenterologist joins NYU Langone to lead Pediatric IBD Program

Grapefruit juice and its effects on prescription drugs

Grapefruit juice and its effects on prescription drugs

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

Mediterranean diet boosts quality of life—here’s how

Mediterranean diet boosts quality of life—here’s how

Study identifies six genetic regions associated with anterior uveitis

Study identifies six genetic regions associated with anterior uveitis

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Wearable devices can identify and predict flare-ups in inflammatory bowel disease

Wearable devices can identify and predict flare-ups in inflammatory bowel disease

Genetic risk factor linked to increased susceptibility to SARS-CoV-2 infection

Genetic risk factor linked to increased susceptibility to SARS-CoV-2 infection

AI-designed drug shows promise for inflammatory bowel disease

AI-designed drug shows promise for inflammatory bowel disease

NYU Langone IBD Center celebrates two years of transforming lives

NYU Langone IBD Center celebrates two years of transforming lives

Mediterranean diet linked to reduced risk of inflammatory bowel disease

Mediterranean diet linked to reduced risk of inflammatory bowel disease

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