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Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.

22 Nov 2021

Other molecules may have greater potential as cancer therapies than gold complex auranofin

The gold complex auranofin has traditionally been used for treating rheumatism but is also being evaluated as a treatment for certain forms of cancer.

22 Nov 2021

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors.

21 Nov 2021

Study explores connections between COVID-19 severity and gene expression in immune cells

New research shows how genetic variations linked to severe cases of COVID-19 affect our immune cells.

21 Nov 2021

Researchers discover new type of cell that may help regulate heart rate

Researchers at the University of Notre Dame discovered a new type of cell in the heart that may help regulate heart rate, and could be an important key in understanding certain types of congenital heart defects and other diseases that involve the heart.

21 Nov 2021

New study uncovers a mechanism of sleep in zebrafish

Why do humans spend a third of their lives sleeping? Why do animals sleep? Throughout evolution sleep has remained universal and essential to all organisms with a nervous system, including invertebrates such as flies, worms, and even jellyfish.

21 Nov 2021

Delta-like SARS-CoV-2 variants with enhanced transmissibility may cause a more severe pandemic

A SARS-CoV-2 variant with traits similar to that of the Delta variant - enhanced transmissibility and an ability to infect people who had previous infections/vaccination - will cause a more severe pandemic with more infections and breakthrough infections/reinfections than variants with either trait alone, according to a mathematical model created by researchers at Harvard T.H. Chan School of Public Health.

21 Nov 2021

MIT researchers uncover a possible new way to combat tumors

Under the right circumstances, the body's T cells can detect and destroy cancer cells. However, in most cancer patients, T cells become disarmed once they enter the environment surrounding a tumor.

21 Nov 2021

A trio of proteins found to drive inflammation in psoriasis

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies - and for many, the relief is temporary.

21 Nov 2021

Scientists can read the brain activity of tiny worm to predict smells

It sounds like a party trick: scientists can now look at the brain activity of a tiny worm and tell you which chemical the animal smelled a few seconds before.

21 Nov 2021

Novel technique solves structure of the HIV capsid alone and in complex with host factors

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

21 Nov 2021

Human lung airway-on-a-chip faithfully recapitulates cystic fibrosis pathology

The inherited progressive disorder cystic fibrosis (CF) causes severe damage to the lungs, and other tissues in the body by affecting the cells that produce mucus, sweat, and digestive juices.

21 Nov 2021

Study reveals molecular architecture of fungal cell walls and structural responses to stress

In a new study published in Nature Communications, Associate Professor Tuo Wang and his research team from the Department of Chemistry at Louisiana State University revealed the molecular architecture of fungal cell walls and the structural responses to stresses, aiding the development of antifungal drugs targeting cell wall components.

21 Nov 2021

Researchers use embryonic stem cell model to study genetic architecture in the hypothalamus

A study led by researchers at Children's Hospital of Philadelphia has implicated several genes involved in a variety of bodily functions associated with the hypothalamus, a notoriously difficult-to-study region of the brain.

21 Nov 2021

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors.

21 Nov 2021

Scientists unravel near-atomic-scale structure of depression-linked brain receptor

Scientists at Scripps Research, Florida have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety.

20 Nov 2021

Sharing large-scale health data to drive forward precision medicine

Precision medicine requires big data. In order to improve the treatment of individuals with cancer, or to understand rare diseases, scientists and clinicians, as well as AI technologies require access to larger sets of health research data that covers diverse populations and wide ranges of conditions.

20 Nov 2021

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

20 Nov 2021

Infant respiratory syncytial virus infection results in metabolic reprogramming of airway epithelial cells

Infection with respiratory syncytial virus during infancy results in metabolic reprogramming of epithelial cells lining the airway, according to a Northwestern Medicine study published in the journal Viruses.

20 Nov 2021

Reducing cell culture contamination with INTEGRA’s versatile pipettes

INTEGRA Biosciences – a leading provider of high quality laboratory equipment – supplies a comprehensive range of liquid handling tools that are ideal for sterile cell biology workflows.

From INTEGRA Biosciences 19 Nov 2021

Life Science News

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Other molecules may have greater potential as cancer therapies than gold complex auranofin

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

Study explores connections between COVID-19 severity and gene expression in immune cells

Researchers discover new type of cell that may help regulate heart rate

New study uncovers a mechanism of sleep in zebrafish

Delta-like SARS-CoV-2 variants with enhanced transmissibility may cause a more severe pandemic

MIT researchers uncover a possible new way to combat tumors

A trio of proteins found to drive inflammation in psoriasis

Scientists can read the brain activity of tiny worm to predict smells

Novel technique solves structure of the HIV capsid alone and in complex with host factors

Human lung airway-on-a-chip faithfully recapitulates cystic fibrosis pathology

Study reveals molecular architecture of fungal cell walls and structural responses to stress

Researchers use embryonic stem cell model to study genetic architecture in the hypothalamus

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

Scientists unravel near-atomic-scale structure of depression-linked brain receptor

Sharing large-scale health data to drive forward precision medicine

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Infant respiratory syncytial virus infection results in metabolic reprogramming of airway epithelial cells

Reducing cell culture contamination with INTEGRA’s versatile pipettes

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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