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New model sheds light on the genetic roots of polygenic diseases

Many statistical models and algorithms used by scientists can be imagined as a "black box." These models are powerful tools that give accurate predictions, but their internal workings are not easily interpretable or understood.

28 Oct 2024

Unlocking the secrets of Usher syndrome

The mistakes are small but carry severe consequences: In Usher syndrome, genetic mutations cause both hearing and vision loss. Cell biologist Professor Uwe Wolfrum from Mainz University is researching the molecular background of this rare genetic disorder - supported by foundations and, not least, by affected individuals themselves

28 Oct 2024

Yourgene Health Cystic Fibrosis Base assay receives IVDR accreditation

Yourgene Health (part of the Novacyt group of companies), a leading international molecular diagnostics group, announces that it has received accreditation under the new EU requirements of the in vitro diagnostic regulation (IVDR) for the Yourgene® Cystic Fibrosis Base assay. The Yourgene Cystic Fibrosis Base assay is a Class C in vitro medical device under IVDR and is intended for use by healthcare professionals within a molecular laboratory environment.

From Yourgene Health 28 Oct 2024

The role of digital platforms in shaping human curiosity

At one point or another, you may have gone online looking for a specific bit of information and found yourself "going down the Wiki rabbit hole" as you discover wholly new, ever-more fascinating related topics - some trivial, some relevant - and you may have gone so far down the hole it's difficult to piece together what brought you there to begin with.

27 Oct 2024

Study reveals the impact of malicious bots on public health communication during COVID-19

The information environment in Finland during the coronavirus pandemic was exceptional and intense in many ways. The spread of disinformation and the number of actors involved reached unprecedented levels.

27 Oct 2024

New prognostic model for predicting outcomes in patients with acute-on-chronic liver failure

Early determination of prognosis in patients with acute-on-chronic liver failure (ACLF) is crucial for optimizing treatment options and liver allocation. This study aimed to identify risk factors associated with ACLF and to develop new prognostic models that accurately predict patient outcomes.

27 Oct 2024

Study aims to construct a circRNA-miRNA-mRNA network in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most fatal malignancies. Epigenetic mechanisms have revealed that noncoding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in HCC progression.

27 Oct 2024

Clinical trial highlights efficacy of imlifidase for kidney transplant recipients

For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX) - a procedure that removes antibodies from the plasma portion of the blood.

27 Oct 2024

Phase 3 trial assesses clazakizumab in kidney transplant recipients with caAMR

Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal antibody that targets the inflammatory cytokine interleukin-6 (IL-6), stabilized kidney transplant recipients' kidney function in a phase 2 trial.

27 Oct 2024

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis.

27 Oct 2024

Clinical utility of carbonic anhydrase IX in diagnosing pleural mesothelioma

Mesothelioma is an aggressive tumor with a poor prognosis. Histological diagnosis of mesothelioma using limited tissue samples can be challenging.

27 Oct 2024

Bioactive peptides from Chlorella vulgaris for therapeutic applications

Chlorella vulgaris is a green, photosynthetic microalga in the phylum Chlorophyta. The goal of our study was to perform a bioinformatics analysis of Photosystem I P700 chlorophyll a apoprotein A2, one of its photosynthesis-related proteins, and to hunt for potent bioactive peptides.

27 Oct 2024

Impact of TLR10 rs10004195 genotype on susceptibility to H. pylori infection

Helicobacter pylori (H. pylori) infection can cause multiple secondary digestive disorders. Some studies have found that polymorphisms in Toll-like receptor (TLR) genes, including TLR10 rs10004195, may be associated with increased susceptibility to H. pylori infection. Despite conflicting reports, we conducted a meta-analysis to clarify the relationship between these factors.

26 Oct 2024

Investigating the relationship between COPD and liver disease in alpha-1 antitrypsin deficiency

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin (AAT) within hepatocytes, which limits its access to the circulation and exposes the lungs to protease-mediated tissue damage.

26 Oct 2024

Medical News

New model sheds light on the genetic roots of polygenic diseases

Unlocking the secrets of Usher syndrome

Yourgene Health Cystic Fibrosis Base assay receives IVDR accreditation

The role of digital platforms in shaping human curiosity

Study reveals the impact of malicious bots on public health communication during COVID-19

New prognostic model for predicting outcomes in patients with acute-on-chronic liver failure

Study aims to construct a circRNA-miRNA-mRNA network in hepatocellular carcinoma

Clinical trial highlights efficacy of imlifidase for kidney transplant recipients

Phase 3 trial assesses clazakizumab in kidney transplant recipients with caAMR

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

Clinical utility of carbonic anhydrase IX in diagnosing pleural mesothelioma

Bioactive peptides from Chlorella vulgaris for therapeutic applications

Impact of TLR10 rs10004195 genotype on susceptibility to H. pylori infection

Investigating the relationship between COPD and liver disease in alpha-1 antitrypsin deficiency

Tenofovir amibufenamide does not alter lipid levels in patients with chronic hepatitis B

MALDI-TOF mass spectrometry proves effective for diagnosing onychomycosis in nail psoriasis

Novel multi-biomarker approach enhances chronic kidney disease risk assessment

Research uncovers how parasitic worms evade itch response

New trial shows felzartamab reduces proteinuria in IgA nephropathy patients

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Fluidics in Modern Healthcare & Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

How does norepinephrine influence anxiety-related behaviours?

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