Stem cells delivered intranasally improve motor function in Parkinson's disease

Stem cells, delivered intranasally, were found to substantially improve motor function in Parkinson's disease in a study co-authored by William H. Frey II, Ph.D, Director of the Alzheimer's Research Center, part of HealthPartners Research Foundation. Frey collaborated with Lusine Danielyan, MD, of University Hospital of Tubingen in Germany. The team had previously published a paper and filed for a patent on this intranasal stem cell delivery method and went on to study the therapeutic impact and long-term survival of the stem cells after they reached the brain. Their new study was published today in Rejuvenation Research.

Using a rat model of Parkinson's disease, the research demonstrated that many of the stem cells delivered intranasally survived for at least six months in the brain; that the stem cells rapidly migrated preferentially to the damaged areas of the brain; and that motor control showed significant improvement. This likely occurred because of the demonstrated anti-inflammatory and neuroprotective effects of the intranasally administered stem cells which were derived from bone marrow.

Intranasal administration of stem cells to the brain is a promising and noninvasive alternative to current surgical procedures. It also opens up the possibility of chronic stem cell treatment, which would increase the number of cells delivered to the brain and likely enhance the therapeutic benefit.

The Alzheimer's Research Center is a national organization that relies on charitable gifts to conduct nationally recognized research for Alzheimer's disease, Parkinson's disease, stroke and other nervous system disorders. The research center has been located on the campus of Regions Hospital in St. Paul, Minn. for more than 30 years.