Report supports potential of focused ultrasound to treat certain OCD patients

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A recently published report in the Journal of Molecular Psychiatry supports the potential of focused ultrasound to treat certain patients with obsessive-compulsive disorder (OCD).

In a study of feasibility, safety and preliminary efficacy, four patients with disabling OCD unresponsive to medical therapy were treated by ablating small targets deep in the brain (anterior internal capsule) using the InSightec ExAblate Neuro MR-guided focused ultrasound system. This proof-of-concept study is being conducted with 12 patients by Jin Woo Chang, MD, PhD, at the Yonsei University Medical Center in Seoul, Korea. The results of the first four patients with six months follow-up were published.

All four patients had the targeted areas of the brain successfully ablated. The procedures were accomplished without complications or side effects and resulted in gradual improvement in obsessive-compulsive thoughts and behaviors as well as showing the nearly immediate and sustained improvement in depression and anxiety over six months.

"There is a need for non-invasive treatment options for patients with OCD that cannot be managed through medication," says Dr. Chang. "Using focused ultrasound, we were able to reduce the symptoms for these patients and help them get some of their life back without the risks or complications of the more invasive surgical approaches that are currently available."

"If these initial results are confirmed in the remaining eight patients in this study as well as in a larger pivotal trial of safety and efficacy, focused ultrasound could emerge as an alternative to surgery for improving quality of life in a cost-effective manner for patients with OCD," said Foundation Chairman Neal F. Kassell, MD. "This could also serve as the predicate for non-invasive therapy for other psychiatric disorders."

Dr. Chang plans to start a study using focused ultrasound to treat depression in 2015.

Current Treatment for OCD
Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by recurring anxiety-provoking thoughts (obsessions) that are alleviated only by ritualistic actions (compulsions) such as hand washing. OCD symptoms can be overwhelming and result in severe impairment and dysfunction. Patients also have a high risk for depression, with two-thirds of OCD patients developing major depression.

Although a large portion of OCD patients improve with drug therapy, some patients have debilitating symptoms that are resistant to treatment. For these patients, psychosurgery can be performed to destroy (ablate) a targeted region of the brain (anterior internal capsule) associated with the disorder. The currently available ablative approaches are invasive or involve radiation:

• Radiofrequency ablation requires drilling into the skull and inserting a probe through the brain.

• Stereotactic radiosurgery takes months to achieve an effect and may be associated with side effects of radiation.

• Deep brain stimulation has been used as a reversible and adjustable alternative to ablation, but it involves the risks and complications of surgery to implant the system and additional operations for battery changes.


  1. Warren Barlowe OCDBehavioral Therapist Warren Barlowe OCDBehavioral Therapist United States says:

    The gold standard for treating OCD currently is Exposure-and-Response-Prevention behavioral therapy, which is self-help therapy directed by a therapist, but carried out at home. It involves meeting with the therapist once or twice a week, and explaining what you struggle with; what you have to do or think to feel temporarily in control of it. (Doing or thinking these compulsive 'rituals' gives relief that lasts for a few minutes, but then you're back to misery again. It's no help.) From this information, the therapist creates a 5
    -minute 'exposure' experience based on your smallest, least difficult ritual
    pattern, that you voluntarily go through, that gives you a very small, tolerable feeling of anxiety. Now, instead of thinking or doing the ritual, you prevent yourself from compulsively responding, and in about 5 more minutes the anxiety goes away by itself (it always goes away after a while if we are willing to wait for a few minutes.) Now you and your therapist celebrate your (small but significant) victory, and you are instructed to go home and repeat the therapy yourself 4 times every day. By the end of the week you no longer have the need to ritualize, and you go on to working on more major rituals!

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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