Researchers to investigate cellular changes leading to development of glioblastoma

Glioblastoma is the most common of malign brain tumors in adults, and it currently has no cure.

Now a research team led by Dr Claudia Barros, from the Plymouth University Peninsula Schools of Medicine and Dentistry and its Brain Tumor Research-funded Centre of Excellence, has secured funding from the Brain Research Trust, which will help to expose novel molecules and their modes of action responsible for the initiation and growth of the disease.

With the collaboration of colleagues from Derriford Hospital and the Medical Research Council Centre for Regenerative Medicine, Edinburgh, Dr Barros will investigate the cellular changes leading to the development of glioblastoma brain tumors - making vital steps in the bid to understand how they are formed and why they are prone to returning.

Using a brain tumor model in Drosophila fruit flies - which were also used by the winners of this year's Nobel Prize for Medicine - the researchers recapitulate hallmarks of human brain cancer stem cell and tumor development. In this model, Dr Barros's team visualizes cancer stem cells at the time they originate inside intact brain, and can identify early cellular and molecular changes.

In this new project, the team is set to investigate comparable changes in cells from glioblastoma patients.

Understanding the origin, driver mutations and properties of brain cancer stem cells is essential to the development of new and more effective treatments targeting these cells. Yet despite ongoing research efforts from teams around the world, Dr Barros explains, knowledge in this area is still limited.

"We hope to contribute to a major current area in brain tumor research that underlies the questions of 'How do brain tumors form, and why do they frequently re-appear after treatment?'" she said.

"Despite efforts by researchers around the world, the basic knowledge of the complex molecular and cellular mechanisms involved is still limited. This has hampered the development of effective targeted therapies.

"The new factors and mechanisms we hope to reveal have the potential to become novel targets for the much needed better therapies against these deadly brain tumors. What we will learn may not only apply to glioblastoma but also to the development of other types of brain tumors, including those of low grade."

Caroline Blakely, Chief Executive Officer of the Brain Research Trust, said: "We are delighted to have been able to support this important work by Dr Barros.

"Neuro-oncology is one of our three priority research themes - reflecting a large unmet patient need coupled with insufficient current research investment. We want to improve the outlook for people with brain tumors by funding research that takes forward our understanding of the mechanisms underlying tumor development and helps develop better ways to diagnose and treat these tumors.

"Glioblastoma is the most common primary malignant brain tumor in adults and is particularly devastating. There is no cure and most patients die within a year of diagnosis. We believe that Dr Barros' work will help change this; by giving an insight into new and more effective ways to treat glioblastoma. We look forward to following her progress."

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