Researchers move one step closer to finding a cure for spina bifida

Researchers on the path to finding a cure for spina bifida have identified specific elements in stem cell secretions as key to protecting neurons and ultimately reducing the lower-limb paralysis associated with the birth defect.

Those elements are exosomes -- vesicles that transfer molecules from cell to cell -- and a small carbohydrate-binding protein known as galectin 1.

The team will use the results to optimize the neuroprotective qualities of a stem cell treatment they developed to improve the mobility issues associated with spina bifida.

Published in the Journal of the Federation of American Societies for Experimental Biology, the study was led by Aijun Wang, co-director of the UC Davis Health Surgical Bioengineering Laboratory.

Altering the outcomes of spina bifida

UC Davis Health fetal surgeon and study co-author Diana Farmer first showed that prenatal surgery reduces neurological defects in children with spina bifida, which occurs when the spinal cord does not properly close before birth. Children with the condition experience a range of lifelong cognitive, urological, musculoskeletal and motor disabilities.

Farmer and Wang, her chief collaborator, later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs) improved hind limb control in lab animals and dogs with spina bifida.

"We wanted to know the specific mechanisms of action of the PMSC treatment that protect neurons," Wang said. "Our new results provide evidence that stem cell secretions containing exosomes that express galectin 1 are an important part of the therapeutic benefits and give us a path for optimizing the neuroprotective qualities of the treatment."

Hope for a cell-free treatment

The new study also could help the researchers produce a cell-free treatment for spina bifida and other spinal cord injuries based on byproducts of stem cells rather than the stem cells themselves, according to Wang.

Stem cells can heal, however they also can influence the broader immune system and treatment site, making the possibility of cell-free treatment highly attractive.

"Stem cell secretions can have the same or similar healing qualities, but also are a more stable and controllable product," Wang said. "We are excited about what we see so far and are anxious to further explore the clinical applications of this research."

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Pfizer-BioNTech vaccine provides strong protection against MIS-C in children aged 5–17