New hydrogel can help with dry mouth relief

A team of scientists from the University of Leeds has developed a new hydrogel that has significant potential for oral care products that can help with dry mouth relief.

The team developed this bio-inspired lubricant to act as an alternative to saliva without additional lipid content. For instance, dry mouth syndrome or xerostomia pose a limitation to the lubrication of oral surfaces in absence of natural saliva, while extra lipid intake is undesirable for these patients especially for the elderly population, where this syndrome is prevalent.

Additionally, the developed formulation can be potentially used to replicate the lubricating properties of fat content in food products, providing the possibility of decreasing caloric content, without sacrificing sensory-related attributes.

The synergistic superlubricity of the novel microgel-reinforced hydrogel offers a unique perspective towards the fabrication of biocompatible aqueous lubricants for dry mouth therapy or the design of non-obesogenic nutritional technologies.

The excelling lubrication performance of this patented microgel-reinforced hydrogel is attributed to the synergistic interactions between the proteinaceous microgels and the biopolymeric hydrogel with benefits of both viscous and boundary lubrication."

Anwesha Sarkar, Principal Investigator, Professor of Colloids and Surfaces, University of Leeds

"The development of this bio-inspired aqueous lubricant technology as an alternative to saliva is a high priority. To date, such superlubricity is not achieved by any other commercial dry mouth therapies as they lack boundary lubrication properties.

"With the help of ERC Proof of Concept Funding, we are now collaborating with Nexus at the University of Leeds and expect to license this technology soon to industries to ultimately provide sustained relief to dry mouth patients."

Source:
Journal reference:

Hu, J., et al. (2020) Synergistic Microgel-Reinforced Hydrogels as High-Performance Lubricants. ACS Macro Letters. doi.org/10.1021/acsmacrolett.0c00689.

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