Ultra-processed foods are silently altering your metabolism, scientists warn

Study identifies metabolic changes caused by ultra-processed foods, raising concerns about their role in obesity, cardiovascular disease, and gut health disruption.

Study: Association of ultra-processed foods intake with untargeted metabolomics profiles in adolescents and young adults in the DONALD cohort study. Image Credit: Rimma Bondarenko / ShutterstockStudy: Association of ultra-processed foods intake with untargeted metabolomics profiles in adolescents and young adults in the DONALD cohort study. Image Credit: Rimma Bondarenko / Shutterstock

Scientists in France and Germany have conducted a study to identify urine and plasma metabolic biomarkers associated with ultra-processed food intake in adolescents and young adults.

The study is currently available as a pre-proof in The Journal of Nutrition

Background

Ultra-processed foods refer to industrially processed food products containing food-derived or reconstituted ingredients and other industrially isolated components. These components are typically used to increase the shelf-life and sensory properties of the products.

The intake of ultra-processed foods is increasing exponentially worldwide, especially in developed countries. Epidemiological studies have consistently linked high intake of ultra-processed foods, particularly animal-based food products and sweetened beverages, to increased risks of obesity, cardiovascular disease, and metabolic disorders.  Excessive intake of ultra-processed foods is also associated with chronic kidney disease, cancer, and neuropsychiatric complications.

Ultra-processed foods contain excessive amounts of added sugars, salts, saturated fats, energy-dense components, and lower amounts of proteins and dietary fibers. Such poor nutrient profiles are believed to be responsible for negative health consequences.

In this study, scientists have determined the associations between ultra-processed food intake both plasma and urine metabolite levels in adolescents and young adults. They applied untargeted metabolomics analysis to capture a wide array of metabolic changes linked to ultra-processed food intake.

The scientists selected these two biological matrices because short-term changes in metabolite levels related to dietary intake are more reliably reflected in urine samples, and plasma samples provide a more stable overview of long-term diet-responsive metabolic states.

Study design

The scientists analyzed data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study, an ongoing study designed to regularly assess and follow healthy infants until adulthood.

The DONALD study has been recruiting healthy infants annually since 1985 and regularly assesses their dietary intake, anthropometric measurements, urine sample collection, blood sample collection, medical parameters, lifestyle factors, and other sociodemographic data.

Data from adolescents who provided 3-day dietary records and 24-hour urine samples was analyzed to determine the association between ultra-processed food intake and urinary metabolic profile.

For young adults, the association between ultra-processed food intake and blood metabolic profile was determined by analyzing 3 or more 3-day dietary records within the 5-year period preceding a single blood measurement.

Important observations

A total of 339 adolescent urine samples and 195 young adult blood samples were analyzed in this study. There was an overlap of 139 participants between the two groups.

The proportions of ultra-processed food intake relative to total food intake in adolescents and young adults were 22% and 23%, respectively. The most commonly consumed ultra-processed foods in both groups were sweetened beverages and ready-to-heat or ready-to-eat food products.

Sweets, chocolates, ice cream, cereals, industrial breads, and processed meats and sausages contributed the most to energy intake.

Impact of ultra-processed food intake on urinary metabolic profile

A total of 42 ultra-processed food-responsive metabolites were identified in adolescent urine samples. Of these metabolites, 21 showed positive associations with ultra-processed food intake.

Among known metabolites identified in urine samples, ultra-processed food intake showed a significant positive association with indoxyl glucuronide and other partially characterized glucuronides. These glucuronides are involved in detoxification processes, notably the elimination of dietary substances through glucuronidation pathways.

Impact of ultra-processed food intake on plasma metabolic profile

A total of six ultra-processed food-responsive metabolites were identified in young adult plasma samples. Of these metabolites, 4-hydroxyglutamate and two structurally unknown metabolites showed positive associations with ultra-processed food intake. 4-hydroxyglutamate has previously been linked to metabolic syndrome and may be an indicator of metabolic stress.

Impact of ultra-processed food intake on urine and plasma metabolite patterns

A total of 25 metabolite patterns, identified using robust sparse principal component analysis (PCA), explained 61.7% of the variance in ultra-processed food-mediated metabolic changes in adolescent urine samples. A significant positive association of ultra-processed food intake was observed with one urinary metabolite pattern (‘xenobiotics and amino acids’) and one plasma metabolite pattern (‘lipids, xenobiotics, and amino acids’).

Both metabolite patterns shared 29 metabolites that were primarily associated with xenobiotic metabolism, which involves the breakdown and elimination of foreign substances like food additives.

Study significance

The study finds that ultra-processed foods can induce changes in urine and plasma metabolite levels in adolescents and young adults through various pathways, including xenobiotic metabolism, amino acid metabolism, and lipid pathways.

The study identifies indoxyl glucuronide and other partially characterized glucuronides as major urinary metabolites positively associated with ultra-processed food intake. Glucuronides are produced during glucuronidation, a key biological detoxification pathway.

Regarding diet-related glucuronidation, evidence suggests that gut microbiome plays a key role in modulating microbial transformation of dietary substrates and glucuronide levels and biosynthesis of microbial metabolites.

It is also well-established in the literature that ultra-processed foods can induce gut microbiota dysbiosis, which in turn is associated with a range of health adversities, including immunological and neuropsychological disorders.

Overall, the study findings provide useful information on the complex biological mechanisms through which ultra-processed foods may affect metabolism and health. The findings also raise concerns about how the displacement of minimally processed foods by ultra-processed options can lead to both nutritional deficiencies and disruptions in gut health.

Journal reference:
Dr. Sanchari Sinha Dutta

Written by

Dr. Sanchari Sinha Dutta

Dr. Sanchari Sinha Dutta is a science communicator who believes in spreading the power of science in every corner of the world. She has a Bachelor of Science (B.Sc.) degree and a Master's of Science (M.Sc.) in biology and human physiology. Following her Master's degree, Sanchari went on to study a Ph.D. in human physiology. She has authored more than 10 original research articles, all of which have been published in world renowned international journals.

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