Chromatography News and Research

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Chromatography in Greek means to ‘write with colors.’ It is a versatile separation technique developed in 1903 by Mikhail Tswett, a Russian botanist. He separated colorful plant pigments using a column of calcium carbonate. Ever since its discovery, chromatography has evolved as a powerful tool in the lab for the separation and identification of different compounds in a mixture.

New workflow tracks lipid changes in oil-producing yeast species

A research team led by Profs. XU Guowang and LIU Xinyu from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS), in collaboration with researchers from Dalian University of Technology, has developed a high-coverage lipidomics workflow and integrated it with transcriptomics to investigate lipid accumulation and compositional changes in Rhodosporidium toruloides under nitrogen limitation.

4 Nov 2026

Blood may reveal signs of gut-related disease that stool samples miss

In a study of 193 participants, researchers found that blood-based short-chain fatty acid profiles distinguished colorectal cancer, celiac disease, obesity, and healthy controls with 95% accuracy, compared with 59% for stool-based measurements. Combining blood and stool profiles increased accuracy to 97%, suggesting that circulating microbial metabolites may offer valuable diagnostic information, although larger studies are needed to validate the findings.

3 Nov 2026

Blueberries reduced blood vessel inflammation in mice, but only with gut microbes present

A preclinical study found that gut microbes help convert blueberry phytochemicals into circulating metabolites, including hippuric acid, that are associated with reduced vascular inflammation. In mice fed a high-fat diet, blueberry supplementation reduced inflammatory markers and monocyte adhesion to blood vessels, but these benefits disappeared following antibiotic-mediated gut microbial depletion.

3 Nov 2026

Ancient protein model shows early steps in energy metabolism

Researchers in Japan engineered ancestral nucleoside diphosphate kinase variants with restricted amino acid repertoires to explore alternative catalytic functions. One variant, Arc1-12KR, retained its protein fold despite lacking catalytic histidine and unexpectedly converted two ADP molecules into ATP and AMP. The findings reveal alternative catalytic potential in simplified proteins and offer clues to possible routes of energy metabolism during early protein evolution.

29 Oct 2026

Novel peptide from red alga shows potential for blood glucose control

It is a dietary staple found in sushi, rice wraps, and ramen toppings. Commonly known as nori in Japan and gim in Korea, red seaweed is especially popular across Asia.

27 Oct 2026

Men with lower testosterone at 31 reported good health 15 years later

Researchers analyzed testosterone concentrations measured at age 31 in 2,691 Finnish men and assessed self-reported health, medical conditions, and quality of life at age 46. Men across testosterone quartiles generally reported good health and excellent quality of life, while differences in metabolic and gastrointestinal conditions lost statistical significance after adjustment for waist circumference.

27 Oct 2026

Scientists found a link between Mediterranean diet blood markers and longer survival

Researchers found that a previously validated 67-metabolite blood signature of Mediterranean diet adherence was associated with lower long-term mortality across a Spanish trial population and three US cohorts. Participants with the highest signature scores had a 23% lower relative hazard of death than those with the lowest scores in both populations, although the findings do not establish a causal relationship.

20 Oct 2026

Coffee, citrus and genetics: What scientists found inside human breast milk

In a bioRxiv preprint, researchers analyzed 458 metabolites in breast milk samples from 349 mothers to investigate how maternal diet, genetics, clinical characteristics, and milk-cell gene expression relate to milk composition. Maternal diet explained the greatest share of metabolite variation among the measured maternal factors, while specific genetic variants and gene-expression patterns were associated with individual metabolites, although the study did not establish effects on infant health.

14 Oct 2026

New research links water source type to antibiotic resistance

Aquatic environments are recognized as reservoirs and pathways for antimicrobial resistance, receiving antibiotic residues and resistant microorganisms from sewage, livestock farming, and aquaculture.

12 Oct 2026

Lipid signaling pathway helps cells survive bacterial toxin damage

Epithelial cells form the body's frontline barriers, helping keep microbes, toxins, and other harmful substances out.

5 Oct 2026

Five lipids revealed a divide between active and inactive pregnancies

Staying active during pregnancy is linked to changes in DHA-rich placental lipids

5 Oct 2026

Eating walnuts daily may boost mood and shift serotonin-related metabolism

Daily walnuts improve mood and alter serotonin-related metabolites in young adults.

2 Oct 2026

New fluorescent paper strips make vitamin B12 testing simpler

Measuring vitamin B12 in food usually means bringing the sample to the laboratory. A new fluorescent sensor could help move part of that process onto something much simpler: a paper strip or cotton swab.

1 Oct 2026

Esophageal cancer leaves a distinct metabolic signature in the gut

The study uncovers gut microbial and metabolic signatures in esophageal cancer, emphasizing lipid dysregulation and its potential role in disease progression.

1 Oct 2026

Breath test shows promise for identifying cancerous lung nodules

The human breath could help identify cancerous lung nodules negating the need for invasive testing.

23 Sep 2026

Common chemical exposures in pregnancy may be linked to early attention and memory

Researchers examined whether prenatal exposure to aromatic amines and cotinine was associated with attention, processing speed, and memory in 250 infants assessed at 7.5 months. The study found mixed patterns across cognitive measures, with several estimates suggesting poorer attention or memory but carrying substantial statistical uncertainty.

23 Sep 2026

Salt-purified seaweed compound suppresses inflammatory and allergic reactions

Food allergies affect an estimated 3%–4% of the global population, yet no definitive cure is currently available.

22 Sep 2026

Older adults with higher polyphenol intake were less likely to have mild cognitive impairment

In a cross-sectional study of 92 older Italian memory-clinic patients, higher habitual intake of total dietary (poly)phenols and several specific subclasses was associated with a lower likelihood of mild cognitive impairment (MCI). Total (poly)phenol intake was not associated with cognitive test performance or circulating inflammatory biomarkers, and the authors cautioned that the small observational study cannot establish causality.

20 Sep 2026

Researchers mine cobra toxins to uncover a membrane-disrupting antimicrobial peptide

Researchers combined toxin sequence mining with machine learning and deep-learning prediction tools to identify and experimentally test 14 antimicrobial peptide candidates derived from cobra cardiotoxins. Most candidates showed limited antibacterial potency, while CTX-p5 displayed moderate membrane-disrupting activity, revealing both the potential and current limitations of computationally guided venom peptide discovery.

17 Sep 2026

Could scorpion venom inspire new treatments for liver disease?

Scorpion venom peptides show promising anti-inflammatory, antiviral, analgesic, and immunomodulatory effects, with experimental evidence suggesting that some candidates could target pathways involved in chronic liver disease and viral hepatitis. The review highlights Kv1.3-blocking peptides and antiviral compounds as potential therapeutic leads, while emphasizing that limited hepatic efficacy data, poor pharmacokinetics, immunogenicity, and manufacturing challenges must be overcome before clinical translation.

8 Sep 2026