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Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

New biomaterial could redefine recovery from brain and central nervous system injuries

A new electrically active transplantable material that can help to regrow cells in the brain and spinal cord could redefine the recovery prospects of patients who sustain life-altering injuries or suffer from neurodegenerative diseases.

10 Jan 2025

Analysis highlights high TBI death rates among older adults and men

A new analysis of U.S. mortality data reveals the disproportionate impact of traumatic brain injuries (TBI) on older adults, males and certain racial and ethnic groups.

10 Jan 2025

Elderberry juice shows promise in boosting gut health and combating obesity

Elderberry juice rich in anthocyanins boosts glucose regulation and fat metabolism, with significant effects on gut microbiota in overweight adults.

10 Jan 2025

Sex-specific mitochondrial marker deficiencies linked to early cognitive dysfunction in Alzheimer’s disease

Research reveals sex-specific free-carnitine deficiency in women with cognitive impairment, linking mitochondrial metabolism to Alzheimer's disease progression.

10 Jan 2025

New therapeutic target could boost CAR T-cell therapy success in solid tumors

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, "TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids".

10 Jan 2025

RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Researchers identify shared genes driving cancer spread

Cancer metastasis-the spread of cancer to other organs-is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across multiple cancer types that drives this deadly process.

10 Jan 2025

Hormonal changes after menopause impact multiple sclerosis severity

A new study by UC San Francisco has found that menopause revs up the progression of multiple sclerosis (MS).

10 Jan 2025

Mussel-inspired nanoparticles for targeted lung cancer therapy

Researchers from POSTECH and Kyungpook National University have developed a novel inhalable therapeutic delivery system for lung cancer, leveraging mucoadhesive protein nanoparticles inspired by the adhesive properties of marine mussels.

9 Jan 2025

Computer model helps tailor CML treatment to individual patients

Which medicine is best when you are affected by cancer? This can vary from person to person. A new method can help people with a specific type of blood cancer get the best medicine for them.

9 Jan 2025

A large-scale tongue cancer organoid library for precision oncology

Oral cancer is an increasingly prevalent disease worldwide, with over 300,000 new cases diagnosed each year. Among oral cancers, tongue cancer (TC) is the most common type and often carries a poor prognosis. Surgery combined with chemoradiotherapy is one of the main lines of treatment for high-risk cases of TC.

9 Jan 2025

Could autophagy enhancement slow aging and combat Alzheimer's?

How cellular cleanup systems could hold the key to slowing aging and halting neurodegeneration.

9 Jan 2025

Lung cancer deaths decrease globally but risk factors still persist

Even though lung and related cancer deaths decreased in the world's 10 most populous countries from 1990 to 2019, these positive statistics do not address trends in mortality linked to tobacco use, air pollution and asbestos exposure.

9 Jan 2025

Study questions accuracy of genetic test for opioid use disorder

Opioid misuse and specifically opioid use disorder (OUD), continues to represent a significant U.S. public health threat, with more than 6 million Americans aged 12 and older meeting the criteria for OUD in 2022.

9 Jan 2025

Comorbid atopic diseases affect prognosis of alopecia areata

Asthma, atopic dermatitis or Hashimoto's thyroiditis as concomitant diseases are risk factors for clinical features associated with a poor prognosis in circular hair loss, also known as alopecia areata (AA).

9 Jan 2025

AI-enhanced algorithm improves diagnosis of REM sleep behavior disorder

A Mount Sinai-led team of researchers has enhanced an artificial intelligence (AI)-powered algorithm to analyze video recordings of clinical sleep tests, ultimately improving accurate diagnosis of a common sleep disorder affecting more than 80 million people worldwide.

9 Jan 2025