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Researchers discover neural mechanism behind leptin resistance and a way to reverse it

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

4 Mar 2025

Novel strategy targets beta cell dysfunction in type 2 diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

4 Mar 2025

Research identifies iron as crucial driver of stroke-related cell death processes

Ischemic stroke continues to rank among the top causes of death and long-term disability globally. While advances in acute treatments like clot retrieval and thrombolysis have improved outcomes, the challenge of managing reperfusion injury—a phase when restored blood flow can ironically harm brain tissue—persists.

4 Mar 2025

Study reveals best treatment strategy for high-risk pulmonary embolism

A current study involving the University Hospital Bonn (UKB) has investigated which treatment strategy offers the best chances of survival in high-risk acute pulmonary embolism.

4 Mar 2025

Study provides a comprehensive cellular map of how diabetes disrupts bone immune interactions

When we think of type 2 diabetes, images of heart problems or kidney damage often come to mind. But lurking quietly behind these well-known complications is another serious threat—bone disease.

4 Mar 2025

How to bridge the historical divide between physical and mental wellness

In a comprehensive Genomic Press Interview published today in Brain Medicine, psychiatry resident Dr. Nicholas Fabiano reveals how a personal injury transformed into groundbreaking research on the intersection of physical and mental health.

4 Mar 2025

Breakthrough study sheds light on Pol-theta’s role in DNA repair and cancer

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these proteins-called polymerase theta (Pol-theta)-for their own survival.

4 Mar 2025

Study explores gene interactions in Alzheimer's disease across brain regions

Alzheimer's disease (AD), a neurodegenerative disorder marked by amyloid plaque buildup and cognitive decline, remains a challenging condition to understand at the molecular level.

4 Mar 2025

Stem cell therapy for cornea injuries demonstrates remarkable results in clinical trial

An expanded clinical trial that tested a groundbreaking, experimental stem cell treatment for blinding cornea injuries found the treatment was feasible and safe in 14 patients who were treated and followed for 18 months, and there was a high proportion of complete or partial success.

4 Mar 2025

Targeting mitochondrial DNA integrity for cardiac protection after injury

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury.

4 Mar 2025

Alpha particle therapy offers new hope for neuroendocrine tumors

In a comprehensive Genomic Press Viewpoint (review) article, researchers are shining a spotlight on a revolutionary approach to tackling neuroendocrine tumors (NETs), a rare but increasingly prevalent form of cancer.

4 Mar 2025

How accurate are continuous glucose monitors? A study puts them to the test

Continuous glucose monitors consistently overestimate fasting and post-meal blood glucose levels compared to capillary blood glucose measurements.

4 Mar 2025

Engineered TIMPs show promise in fighting glioblastoma invasion

A new research paper was published in Oncotarget, Volume 16, on February 28, 2025, titled "Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells."

3 Mar 2025

Heart disease risk drops in walkable areas—but only when residents agree they’re walkable

Researchers found that perceived—but not objective—neighborhood walkability is linked to lower cardiovascular disease (CVD) risk, while food environment showed no significant impact after adjustments.

3 Mar 2025

New brain imaging technique offers hope for better stroke rehabilitation

A new Georgetown University Medical Center study in collaboration with MedStar Health and the National Institutes of Health exploring a new brain imaging technique is bringing stroke experts a step closer to better tailoring rehabilitation.

3 Mar 2025

Epstein-Barr virus infection predisposes people to develop Crohn's disease

Crohn's disease, a debilitating inflammatory bowel disease, has many known contributing factors, including bacterial changes in the microbiome that foster an inflammatory environment.

3 Mar 2025

Anti-malarial drug pyronaridine could be repurposed to treat cancer

Can a drug that's used to treat malaria be repurposed to fight cancer? Researchers at The University of Texas at El Paso have secured a patent for the anti-malarial drug pyronaridine to do just that. Pyronaridine has been used to treat the mosquito-borne infectious disease for over 30 years.

3 Mar 2025

Study reveals key cause of ventilator-induced lung injury

A new study from Tulane University suggests that repeated collapse and reopening of tiny alveoli-air sacs in the lungs essential for breathing-during mechanical ventilation may cause microscopic tissue damage, playing a key role in ventilator-related injuries that contribute to thousands of deaths annually.

3 Mar 2025

Simple algorithm may help reduce treatment disparities in multiple sclerosis

A simple treatment algorithm may help reduce treatment disparities for Hispanic and Black people with multiple sclerosis (MS), according to a preliminary study released today, March 3, 2025, that will be presented at the American Academy of Neurology's 77th Annual Meeting taking place April 5–9, 2025, in San Diego and online.

3 Mar 2025

UQ clinical study seeks participants with PTSD and complex PTSD

University of Queensland researchers are seeking participants diagnosed with PTSD and complex PTSD for a clinical study aimed at improving understanding of its impacts on the brain and overall well-being.

3 Mar 2025