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Self-destructing vaccine offers safer TB protection in monkeys

A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published today in Nature Microbiology.

10 Jan 2025

T cells can completely prevent viral infections in humans

Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells-white blood cells that can destroy harmful pathogens-can completely prevent viral infection, to an extent previously thought only possible due to neutralizing antibodies.

10 Jan 2025

Exploring sexual health challenges in women with pelvic floor disorders

Many women experience problems due to a weakened or damaged pelvic floor. These ailments are most common in pregnant women, women who have recently given birth, and menopausal women. However, pelvic floor disorders can affect all women.

10 Jan 2025

Brain maturation delays linked to unhealthy eating behaviors in youth

More than half of 23-year-olds in a European study show restrictive, emotional or uncontrolled eating behaviors, according to new research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.

10 Jan 2025

Breakthrough microscopy technique reveals how antibodies target cancer cells

In blood cancers such as chronic lymphocytic leukaemia, B cells of the immune system multiply uncontrollably.

10 Jan 2025

Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

Most disease-causing mutations that swap amino acids do so by making proteins less stable

Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.

10 Jan 2025

Analysis highlights high TBI death rates among older adults and men

A new analysis of U.S. mortality data reveals the disproportionate impact of traumatic brain injuries (TBI) on older adults, males and certain racial and ethnic groups.

10 Jan 2025

Dairy products linked to lower colorectal cancer risk, thanks to calcium

This study reveals strong links between calcium intake and reduced colorectal cancer risk, highlighting dietary factors influencing cancer incidence in women.

10 Jan 2025

Pittcon addresses synthetic psychedelics crisis; Boston 2025 to advance collaboration

Pittcon 2025 in Boston will connect industry experts to combat the synthetic psychedelic threat, enhancing testing protocols and public health initiatives.

From Pittcon 10 Jan 2025

Elderberry juice shows promise in boosting gut health and combating obesity

Elderberry juice rich in anthocyanins boosts glucose regulation and fat metabolism, with significant effects on gut microbiota in overweight adults.

10 Jan 2025

Sex-specific mitochondrial marker deficiencies linked to early cognitive dysfunction in Alzheimer’s disease

Research reveals sex-specific free-carnitine deficiency in women with cognitive impairment, linking mitochondrial metabolism to Alzheimer's disease progression.

10 Jan 2025

Groundbreaking research uncovers how neurons organize natural behaviors

Eight years of work. A collaboration between the Laboratory of Neuroethology of Non-Human Primates of the Department of Medicine and Surgery of the University of Parma, led by Luca Bonini, and a team from the Biorobotics Institute of the Sant'Anna School of Pisa, coordinated by Alberto Mazzoni, principal investigator at the Computational Neuroengineering Lab, with the contribution of Silvestro Micera, professor in Bioingeneering.

10 Jan 2025

New therapeutic target could boost CAR T-cell therapy success in solid tumors

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, "TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids".

10 Jan 2025

RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Researchers identify shared genes driving cancer spread

Cancer metastasis-the spread of cancer to other organs-is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across multiple cancer types that drives this deadly process.

10 Jan 2025

Hormonal changes after menopause impact multiple sclerosis severity

A new study by UC San Francisco has found that menopause revs up the progression of multiple sclerosis (MS).

10 Jan 2025

Mussel-inspired nanoparticles for targeted lung cancer therapy

Researchers from POSTECH and Kyungpook National University have developed a novel inhalable therapeutic delivery system for lung cancer, leveraging mucoadhesive protein nanoparticles inspired by the adhesive properties of marine mussels.

9 Jan 2025

Computer model helps tailor CML treatment to individual patients

Which medicine is best when you are affected by cancer? This can vary from person to person. A new method can help people with a specific type of blood cancer get the best medicine for them.

9 Jan 2025

Developing and refining muscle atrophy models for drug discovery

With the intensification of global population aging, muscle atrophy, characterized by the loss of muscle mass and function, has become an important health issue affecting the elderly. Researchers have widely used various animal and cellular models to gain a deeper understanding of the pathophysiological mechanisms of muscle atrophy and develop effective treatment strategies.

9 Jan 2025