Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Reimagining axons with the pearls-on-a-string model

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

6 Dec 2024

Chronic traumatic encephalopathy risk in ice hockey increases with each year played

A study of 77 male hockey players reveals a 96.4% CTE prevalence, highlighting the link between play duration and increased risk of chronic encephalopathy.

6 Dec 2024

New computational pipeline identifies key biomarkers for Alzheimer's disease

Researchers at Columbia University Mailman School of Public Health have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including Alzheimer's disease (AD).

6 Dec 2024

Early ovarian removal and APOE4 increase Alzheimer's risk in women

New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone therapy mitigates this risk.

5 Dec 2024

Scientists link proteins to Alzheimer’s through cutting-edge genetic method

Researchers have developed MR-SPI, a novel method integrated with AlphaFold3, to identify causal protein biomarkers and predict their 3D structural changes in Alzheimer’s disease. This breakthrough offers insights into disease mechanisms and potential therapeutic targets.

5 Dec 2024

Frontotemporal dementia disrupts empathy for pain, study reveals

Study reveals diminished brain activity related to empathy for pain in individuals with behavioral variant frontotemporal dementia (bvFTD), using task-based fMRI. Findings show a stark reduction in neural responses tied to affective empathy, highlighting early bvFTD impacts on social cognition.

5 Dec 2024

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Alzheimer's genetic risk studies undermined by systemic biases

Recent research in Nature Genetics reveals pervasive biases in GWAX studies using parental history of Alzheimer’s, highlighting potential misdirection in genetic associations and disease risk predictions. A novel GSUB method identifies false signals stemming from confounding factors like survival bias and socioeconomic status.

4 Dec 2024

Glyphosate exposure linked to lasting brain inflammation

The human brain is an incredibly adaptable organ, often able to heal itself even from significant trauma.

4 Dec 2024

Spider brain studies lead to breakthrough in understanding human brain diseases

Researchers from Saint Michael's College and the University of Vermont have made a groundbreaking new discovery that provides a better understanding of how Alzheimer's disease develops in the human brain.

4 Dec 2024

Type 2 diabetes doubles infection-related mortality and exposes gaps in health reporting

People with type 2 diabetes face a significantly higher risk of infection-related deaths, particularly in younger age groups, with infections accounting for 13% of deaths compared to 1.2% in conventional records.

3 Dec 2024

Behavioral chaos in Alzheimer’s disease mice decoded by machine learning

Researchers use machine learning to identify behavioral disruptions in Alzheimer’s disease mouse models, highlighting a potential therapeutic target in fibrinogen-microglia interactions.

3 Dec 2024

Researchers aim to uncover causes of acquired hearing loss and find potential therapies

With a new five-year, $3.2 million grant from the National Institute on Deafness and Other Communications Disorders, researchers at Case Western Reserve University and Mass Eye and Ear will study what causes acquired hearing loss (AHL) and seek new ways to protect against it.

3 Dec 2024

High blood sugar impairs brain health even without diabetes

A study by Baycrest found that high blood sugar may impair brain health even in people without diabetes.

3 Dec 2024

Baycrest study discovers role of thalamus in post-stroke recovery

A recent study by Baycrest reveals that an area of the brain distinct from the stroke lesion may play a significant role in causing the life-altering symptoms survivors are often left with, which can include severe challenges with speech, mobility and cognition.

3 Dec 2024

Loss of empathy in frontotemporal dementia linked to brain activity changes

Patients with frontotemporal dementia often lack the ability to empathize. A study at Karolinska Institutet has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is hoped will increase understanding of this specific dementia disease.

3 Dec 2024

Lifestyle choices and cognitive health linked to future dementia risk

The risk of developing dementia later in life is strongly predicted by a person's cognitive ability, functional limitations and physical health as many as 20 years before onset of the illness, according to a new RAND report.

3 Dec 2024

Skeletal muscle loss linked to increased risk of dementia

Skeletal muscle loss is a risk factor for developing dementia, according to a study being presented today at the annual meeting of the Radiological Society of North America (RSNA).

3 Dec 2024

Research sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression

Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.

3 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Reimagining axons with the pearls-on-a-string model

Chronic traumatic encephalopathy risk in ice hockey increases with each year played

New computational pipeline identifies key biomarkers for Alzheimer's disease

Early ovarian removal and APOE4 increase Alzheimer's risk in women

Scientists link proteins to Alzheimer’s through cutting-edge genetic method

Frontotemporal dementia disrupts empathy for pain, study reveals

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Alzheimer's genetic risk studies undermined by systemic biases

Glyphosate exposure linked to lasting brain inflammation

Spider brain studies lead to breakthrough in understanding human brain diseases

Type 2 diabetes doubles infection-related mortality and exposes gaps in health reporting

Behavioral chaos in Alzheimer’s disease mice decoded by machine learning

Researchers aim to uncover causes of acquired hearing loss and find potential therapies

High blood sugar impairs brain health even without diabetes

Baycrest study discovers role of thalamus in post-stroke recovery

Loss of empathy in frontotemporal dementia linked to brain activity changes

Lifestyle choices and cognitive health linked to future dementia risk

Skeletal muscle loss linked to increased risk of dementia

Research sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression

Ketone metabolism redefines protein quality control in aging brains

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Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

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