University of Padua Professor wins Paul Ehrlich and Ludwig Darmstaedter Prize

$139,000 awarded for contribution to the field of bacterial diseases

Frankfurt am Main. The chemist and biologist Professor Cesare Montecucco, 62, of the Department of Biomedical Research at the University of Padua, Italy, has won the 100,000 euro Paul Ehrlich and Ludwig Darmstaedter Prize 2011 for his contribution to research in the field of bacterial diseases, including tetanus, botulism, anthrax and Helicobacter pylori associated diseases. The award was conferred by the Scientific Board of the Paul Ehrlich Foundation. The Paul Ehrlich and Ludwig Darmstaedter Prize is among the most prestigious international awards granted in the Federal Republic of Germany in the field of medicine. The award ceremony will take place in the Paulskirche in Frankfurt on March 14, 2011, the birthday of Paul Ehrlich (1854-1915).

Cesare Montecucco is engaged in research into human diseases caused by different pathogens of bacterial and animal origin. He has provided important insights in the molecular pathogenesis of tetanus, botulism, anthrax and gastrointestinal diseases due to Helicobacter pylori. Major contributions were those regarding the mechanism of action the neurotoxins that cause botulism and tetanus and tetanus, caused by the tetanus bacterium Clostridium tetani and characterized by a muscular rigidity popularly known as "lockjaw." These neurotoxins provided a major evidence that the SNARE proteins are the core of the nanomachine which mediates neurotransmitter release at the synapse, and more in general of most events of vesicle fusion with the target membrane within the cell.

Professor Cesare Montecucco was born in Trento, Italy, in 1947 and studied chemistry and biology at the University of Padua, Italy, where he is currently Professor of Pathology and Deputy Director of the Scuola Galileiana. He also did research at Cambridge University in the UK, in the Dutch city of Utrecht, at the Institut Pasteur in Paris, France, at the European Molecular Biology Laboratory in Heidelberg, Germany and at the University of Costa Rica. Professor Montecucco has published over 250 articles and edited three books. He is a member of the board of various leading scientific journals and acts within the scientific committees of several institutes. In addition, he is a member of the European Molecular Biology Organization, the German Academy of Sciences Leopoldina, the Istituto Veneto di Scienze Lettere ed Arti, the Academia Europaea and the American Academy of Microbiology. For his contributions to the field of infectious diseases, Cesare Montecucco was awarded the Shipley Award of Harvard Medical School in 1993, the Prize of the Italian Consortium for Biotechnology in 1998, the Prize of the Deutsche Gesellschaft f-r Hygiene und Mikrobiologie in 2000, the Prize of the Masi Foundation for Venetian Civilization in 2003, the Feltrinelli Prize for Medicine in 2004 and the Redi Award of the International Society on Toxinology in 2009.