Light alcohol consumption may increase risk of certain cancers

The majority of observational studies have shown that alcohol intake, especially heavy drinking, increases a number of upper-aero-digestive tract (UADT) and other cancers, and even moderate drinking is associated with a slight increase in the risk of breast cancer. A meta analysis published in the Annals of Oncology compares the effects between light drinkers (an average reported intake of up to 1 typical drink/day) versus "non-drinkers" in terms of relative risks for a number of types of cancer.

The authors concluded that while the risk of these cancers was only slightly increased from such drinking, there were detectable increases in cancers of the oral cavity and pharynx, esophagus and female breast. They report no increase in the risk of cancers of the colorectum, liver, and larynx to be associated with such drinking.

Forum reviewers were concerned about a number of aspects of this study. While the statistical methodology was correct and done appropriately, the fact that the investigators (1) included both ex-drinkers and never drinkers in the reference group; (2) could not separate the effects of regular light drinking from binge drinking; (3) had no data on the duration of alcohol consumption at different levels; (4) did not adjust their analyses according to geographic region or type of study (both of which had large estimated effects on cancer risk); and (5) did not adjust their estimates of effect by other lifestyle habits, including smoking. All of these factors tend to weaken the implications of their results.

Forum reviewers were also concerned that despite the acknowledged limitations of their data, the authors present conclusions indicating that even light drinking increases the risk of certain cancers without commenting on the net health effects. They present only the effects on cancer (which was the topic of the meta-analysis) but do not comment on the overall or net health effects of light drinking: a marked reduction in the risk of much more common diseases, especially cardiovascular diseases, and a longer lifespan. Further, the lack of data on genetic patterns, folate intake, and other lifestyle factors makes it difficult to apply their findings to individual subjects. The Forum considers that while their analyses may be helpful in understanding associations between alcohol and cancer, the many limitations of this study indicate that it can provide only incomplete information on light alcohol consumption to be used as a basis for making recommendations to the public.


  1. JS Butlerson JS Butlerson United States says:

    This author seems very defensive to be having their favorite mind-altering addictive drug viewed negatively. Alcohol may have some positive effects, just like smoking also does, but no one is going to encourage smoking, anymore than any responsible medical person should ever encourage the use of the world's most destructive drug - alcohol.  Over 70% of USAmericans polled say alcohol has adversely affected their lives and it would take me 3 hands worth of fingers to count the deaths due to alcohol of family, friends and co-workers from first or second hand alcohol, yet none of these same groups have any died from smoking.

    According to the WHO alcohol kills 6.5 times more people worldwide than all other drugs combined.  Too many people, including in the medical fields, are alcohol users, and it is disturbing to think they will try to pretend that alcohol is a positive health choice.  

    I'm shocked that such a pro-drug article could be published on this medical website.  Alcohol destroys lives and quality of lives, causes awful birth defects (how can that be if it is so healthy?), causes disease, destroys childhoods and careers and families, it costs the US over $220 Billion every year!

    Whoever wrote this idiotic paean to this ugly drug needs to conduct some serious self-evalutations of their problems and get some help.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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