Mice study reveals brain-heart biomarker for epilepsy after malaria

Animals that develop epilepsy after an infection can be identified as early as three months prior to their first seizure by measuring interactions between the brain and the heart, according to new research using a mouse model of post-cerebral epilepsy. Published in JNeurosci, this finding could inform efforts to diagnose and treat acquired epilepsy.

Cerebral malaria afflicts more than three million people worldwide, affects young children, and leads to epilepsy in an estimated 15 percent of survivors. Reducing the risk of developing epilepsy and associated fatal complications, such as sudden unexplained death in epilepsy, requires a reliable way to detect and monitor epileptogenesis.

By recording neural and cardiac activity in a mouse model of cerebral malaria, Fatemeh Bahari, Bruce Gluckman and colleagues discovered a signal transmitted between the brain and the heart that occurred only in the 75 percent of mice that acquired epilepsy. Translating this biomarker to humans has the potential to improve therapeutic approaches in patients at risk of developing epilepsy, such as those recovering from traumatic brain injury or stroke.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Society for Neuroscience. (2019, June 20). Mice study reveals brain-heart biomarker for epilepsy after malaria. News-Medical. Retrieved on December 01, 2022 from https://www.news-medical.net/news/20180828/Mice-study-reveals-brain-heart-biomarker-for-epilepsy-after-malaria.aspx.

  • MLA

    Society for Neuroscience. "Mice study reveals brain-heart biomarker for epilepsy after malaria". News-Medical. 01 December 2022. <https://www.news-medical.net/news/20180828/Mice-study-reveals-brain-heart-biomarker-for-epilepsy-after-malaria.aspx>.

  • Chicago

    Society for Neuroscience. "Mice study reveals brain-heart biomarker for epilepsy after malaria". News-Medical. https://www.news-medical.net/news/20180828/Mice-study-reveals-brain-heart-biomarker-for-epilepsy-after-malaria.aspx. (accessed December 01, 2022).

  • Harvard

    Society for Neuroscience. 2019. Mice study reveals brain-heart biomarker for epilepsy after malaria. News-Medical, viewed 01 December 2022, https://www.news-medical.net/news/20180828/Mice-study-reveals-brain-heart-biomarker-for-epilepsy-after-malaria.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post
You might also like...
Short chain fatty acid supplementation improves stroke recovery, mice study shows