Mucus-based prophylactic gel protects against HIV and herpes transmission

A mucus-based prophylactic gel developed at KTH Royal Institute of Technology has proven 70 percent effective in lab tests against HIV, and 80 percent effective against herpes.

The viral prophylactic tests were conducted in a lab on several types of cells. The results were reported today in the scientific journal, Advanced Science.

Lead-author Hongji Yan, a biomaterials researcher at KTH, says the promising results raise hope that when it becomes available as a product, the gel could help reverse troubling trends in HIV spread.

The lubricant is derived from mucin, a main component of mucus that is produced in the human body, though suppliers provide the bovine type in purified form for fabrication of hydrogels.

Hongji says the natural complexity of the mucin molecules is the reason the synthetic gel is so effective at stopping the HIV and herpes, without the risk of side effects or development of resistance. Such properties would be difficult to achieve with a polymer made from scratch, he says.

In our body, mucin molecules can bind to and trap virus particles, which are then cleared through active mucus turnover. Hongji says the synthetic gel replicates this self-healing function, which is a key material property that enables mucus' lubricity and prophylaxis against infection.

Hongji says the gel could help more people take greater control of their sexual health. It could offer protection when condom protection is not an available option, or even as back-up protection in case of condom failure or incorrect use. It could be used in both female-to-male sex and male-to-male sex.

The mucins in the synthetic gel also help to dampen the activation of immune cells, he says. This is important because activated immune cells stimulate HIV replication.

More than 1 million sexually transmitted infections (STIs) are acquired every day worldwide and most of these are asymptomatic, according to the World Health Organization (WHO). Adolescent girls and young women are twice as likely as men to contract HIV as their male counterparts, according to UNAIDS.

The project is a collective effort of laboratories at KTH Royal Institute of Technology, the Technical University of Munich (TUM) and Karolinska Institutet. Analysis of the lubricating properties of the gel was performed by Martin Kretschmer at TUM. Viral tests were performed by Rafael Ceña-Diez at Karolinska Institutet.

Source:
Journal reference:

Kretschmer, M., et al. (2022) Synthetic Mucin Gels with Self-Healing Properties Augment Lubricity and Inhibit HIV-1 and HSV-2 Transmission. Advanced Science. doi.org/10.1002/advs.202203898.

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