Chromatography News and Research

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Chromatography in Greek means to ‘write with colors.’ It is a versatile separation technique developed in 1903 by Mikhail Tswett, a Russian botanist. He separated colorful plant pigments using a column of calcium carbonate. Ever since its discovery, chromatography has evolved as a powerful tool in the lab for the separation and identification of different compounds in a mixture.

The impact of SARS-CoV-2 on lipids

SARS-CoV-2 appears to alter host lipid biosynthesis by relying on certain human metabolic pathways to survive and multiply effectively.

20 Feb 2022

Researchers use an integrated approach to reveal constituents in a multi-herb Chinese medicine

Rooted in ancient knowledge and principles, traditional Chinese medicine (TCM) has been used to treat many diseases, sparking the interest of pharmaceutical researchers. TCM formulas are quite complex, requiring multiple herbs for their formulation.

18 Feb 2022

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

Researchers developed a ‘bait and capture’ system which was further followed by a multiplexed and targeted proteomic liquid chromatography-tandem mass spectrometry analyses for the comparison of immune correlates in response to vaccination, natural infection, as well as protection against SARS-CoV-2 variants.

18 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Process-scale Chromatography Bed Supports

Porvair Sciences high performance, precision manufactured Vyon® porous plastics are perfect support materials for chromatographic resins used in the isolation and purification steps of pharmaceutical drug and vaccine production.

From Porvair Sciences Limited 9 Feb 2022

Fast & efficient evaporator for chromatography solvents

Designed to provide dry down of samples in microplates and glass tubes up to 150 mm in length - the Ultravap® Mistral XT150 blowdown evaporator from Porvair Sciences offers a low maintenance, sample-safe alternative to using water bath-based evaporators.

From Porvair Sciences Limited 6 Feb 2022

Researchers develop influenza virus-like particle-based hybrid vaccine for both influenza and SARS-CoV-2 viruses

In a new study, a team of researchers developed a hybrid vaccine for SARS-CoV-2 and influenza viruses using influenza virus-like particles (VLP).

4 Feb 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients

An interdisciplinary team of researchers from Europe analyzed the alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients.

26 Jan 2022

Paxlovid provides a glimpse into the future against SARS-CoV-2

A recent study reveals that nirmatrelvir is potent and effective against the SARS-CoV-2 Omicron variant.

23 Jan 2022

Rapid, highly accurate drug detection vital to reducing the adverse impacts of addiction

Rapid, accessible and highly accurate detection of addictive substances such as opiates and cocaine is vital to reducing the adverse personal and societal impacts of addiction, something current drug detection systems can take too long to provide.

22 Jan 2022

Echinacea as a potential force against coronavirus infections

A new review identified clinical studies evaluating coronavirus infections in the context of Echinacea administration and assessed preventive and therapy advantages against COVID-19.

21 Jan 2022

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

Researchers have discovered a new way to induce immunity against the RBD.

19 Jan 2022

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

New research suggests that the SARS-CoV-2 Omicron spike protein requires significantly higher levels of ACE2 for efficient membrane fusion, lagging behind other variants.

14 Jan 2022

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

A team of researchers recently analyzed differential protein glyco-isoform distributions of symptomatic and asymptomatic coronavirus disease 2019 patients.

11 Jan 2022

Collaborative approaches to honey adulteration detection

In this interview, we spoke to Marisa Amadei and Professor Norberto Luis Garcia to explore the impact of honey fraud on global food supply chains.

From Bruker BioSpin Group 10 Jan 2022

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Alzheimer's disease (AD) is a progressive neurological disease that causes impairments in memory and cognition. AD is believed to result from the deposition of protein "plaques" consisting of amyloid beta (Aβ) proteins sequentially generated via the enzyme γ-secretase.

7 Jan 2022

Streamlined, efficient approaches to cell culture spectrometry and analysis

As demand for the high throughput production of high quality, highly specialized and reliable cell culture products continues to rise, laboratories and manufacturers need to move away from traditional manual analysis methods in favor of advanced real-time analysis using power spectroscopic methods.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 6 Jan 2022

Exploring the impact of DNA nanoswitches in RNA purification

A new study reports a tool to enable RNA purification by sequence, helping to determine the structure, chemical modifications, and interactions between different RNA molecules.

15 Dec 2021

SARS-CoV-2 patients exhibit high specialized pro-resolving molecule serum levels

In a new study, researchers compared the serum levels of bioactive lipids in a cohort of 50 in-patients who had confirmed symptomatic SARS-CoV-2 infection with that of a control group.

14 Dec 2021

Chromatography News and Research

Further Reading

The impact of SARS-CoV-2 on lipids

Researchers use an integrated approach to reveal constituents in a multi-herb Chinese medicine

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Process-scale Chromatography Bed Supports

Fast & efficient evaporator for chromatography solvents

Researchers develop influenza virus-like particle-based hybrid vaccine for both influenza and SARS-CoV-2 viruses

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

Alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients

Paxlovid provides a glimpse into the future against SARS-CoV-2

Rapid, highly accurate drug detection vital to reducing the adverse impacts of addiction

Echinacea as a potential force against coronavirus infections

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

Collaborative approaches to honey adulteration detection

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Streamlined, efficient approaches to cell culture spectrometry and analysis

Exploring the impact of DNA nanoswitches in RNA purification

SARS-CoV-2 patients exhibit high specialized pro-resolving molecule serum levels

Enhancing confidence in chemical ionization spectrometry data eBook

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