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New genomic insights could transform bipolar disorder treatment

Study published in Nature identifies nearly 300 genomic regions associated with bipolar disorder, and 36 key genes involved in the disease.

23 Jan 2025

Singapore’s respiratory health gets a boost with $10 million research grant

The Academic Respiratory Initiative for Pulmonary Health (TARIPH) Centre, a national research platform led by Nanyang Technological University, Singapore's (NTU Singapore) Lee Kong Chian School of Medicine (LKCMedicine), will lead a multi-institutional research programme after being awarded Singapore's first national research grant for respiratory health.

23 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

Adults with ADHD found to have reduced life expectancy

Adults who have been diagnosed with attention deficit hyperactivity disorder (ADHD) may be living shorter lives than they should, finds a world-first study led by UCL researchers.

23 Jan 2025

Study reveals potential drug links to Dementia risk

Findings from a large-scale review indicate certain medications may influence dementia risk, offering insights for prevention and drug repurposing strategies.

23 Jan 2025

Dapagliflozin and calorie restriction show higher remission rates in type 2 diabetes

Adults with overweight or obesity and type 2 diabetes who are given the sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin alongside moderate calorie restriction achieve much higher rates of remission compared with calorie restriction alone, finds a trial published by The BMJ today.

23 Jan 2025

Real-world effectiveness and safety of olaparib in HRD-positive BRCA wild-type ovarian cancer

Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy.

23 Jan 2025

New study links intestinal protein to food allergy development

When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine - and a specific protein secreted by intestinal goblet cells that influences that balance.

22 Jan 2025

Study finds sharp increase in mental health admissions among children in England

There was a 65% increase in the number of children and young people being admitted to general acute medical wards in hospitals in England because of a mental health concern between 2012 and 2022, finds a new study led by UCL researchers.

22 Jan 2025

New Factor XI inhibitor shows superior safety in treating atrial fibrillation

Patients with atrial fibrillation are typically prescribed an anticoagulant, or blood thinner, to reduce the risk of stroke, but many may discontinue them or never receive a prescription due to concerns of increased risk of bleeding complications.

22 Jan 2025

Researchers construct a detailed structural map of GABAA receptors in the human brain

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with each other.

22 Jan 2025

Insilico Medicine doses first patient in Phase I Trial of ISM6331 for mesothelioma

Insilico Medcine( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors.

22 Jan 2025

Strong heart, strong bones: How cardiovascular health influences bone density

Higher cardiovascular health (Life’s Essential 8 scores) is linked to greater bone mineral density in adults aged 20–59, with stronger associations in younger individuals, women, and those with normal BMI, suggesting heart-healthy habits may protect bone strength.

22 Jan 2025