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New brain study explains why some pain becomes chronic

A new study reveals that when we experience short-term (acute) pain, the brain has a built-in way to dial down pain signals - like pressing the brakes - to keep them from going into overdrive.

20 Jun 2025

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).

20 Jun 2025

New lab method accelerates diagnosis of genetic disorders of the immune system

A new laboratory method developed by researchers at Columbia University Vagelos College of Physicians and Surgeons may now help physicians more quickly diagnose patients with suspected genetic disorders of the immune system, many who have been trapped in diagnostic limbo for years.

20 Jun 2025

Researchers find unique genetic profile in childhood cancer survivors with cardiomyopathy

Scientists at St. Jude Children’s Research Hospital studied how common and rare genetic variants influence late-onset cardiomyopathy risk, highlighting the unique genetic complexity of childhood cancer survivors.

20 Jun 2025

SFARI releases largest dataset on hospitalized children with autism

The Simons Foundation Autism Research Initiative (SFARI) has released phenotypic and genetic data from the Autism Inpatient Collection (AIC), a cohort of more than 1,500 youth participants ages 4 to 20 years old who were hospitalized in one of six child psychiatry units in the United States.

20 Jun 2025

Trial shows limited bone protection from weighted vests or resistance training in older adults

A new randomized clinical trial, led by a team of researchers from Wake Forest University School of Medicine and Wake Forest University, did not find evidence that wearing a weighted vest or engaging in resistance training prevented bone loss in older adults undergoing intentional weight loss.

20 Jun 2025

Cord blood proteins help detect early sepsis in preterm infants

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues identified several proteins from the umbilical cord blood of preterm newborns that signal acute systemic inflammation as an immune response to infection, providing objective and noninvasive means to diagnose early onset sepsis.

20 Jun 2025

Bedtime screen habits linked to poor sleep in tweens

Good sleep is vital for adolescents' physical health, mental well-being, and academic success - yet many don't get enough rest. Now, a new study reveals bedtime screen habits may be to blame.

20 Jun 2025

Discovery of key protein reveals why exercise strengthens muscles and bones

"Exercise is good for your health" is a well-known phrase, but few people can clearly explain how and why it benefits the human body."

20 Jun 2025

Scientists develop tool to predict bowel cancer drug resistance

Scientists have developed a tool that can predict how bowel cancer adapts to treatment – helping researchers to design new personalized drugs that will keep patients living well for longer.

20 Jun 2025

Immune changes predict heart risks in cancer patients on checkpoint inhibitors

New research has uncovered immune changes in cancer patients that could help identify which patients are most at risk of dangerous heart complications from cancer drugs, known as immune checkpoint inhibitors.

20 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Multiple brain profiles underlie the same symptoms in depression

A novel study aimed at disentangling the neurological underpinnings of depression shows that multiple brain profiles may manifest as the same clinical symptoms, providing evidence to support the presence of both one-to-one and many-to-one heterogeneity in depression.

20 Jun 2025

Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinoma

A new review published in Genes & Diseases explores the intricate epigenetic regulatory network of long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC), shedding light on the profound impact of DNA methylation, histone modifications, RNA methylation, and microRNAs on lncRNA transcription.

20 Jun 2025

Placenta and prenatal hormones may drive human brain evolution

The placenta and the hormones it produces may have played a crucial role in the evolution of the human brain, while also leading to the behavioral traits that have made human societies able to thrive and expand, according to a new hypothesis proposed by researchers from the Universities of Cambridge and Oxford.

20 Jun 2025