Sepsis

Sepsis is a life-threatening illness. Your body's response to a bacterial infection usually causes it. Your immune system goes into overdrive, overwhelming normal processes in your blood. The result is that small blood clots form, blocking blood flow to vital organs. This can lead to organ failure. Babies, old people and those with weakened immune systems are most likely to get sepsis. But even healthy people can become deathly ill from it.

Everything You Need To Know About Sepsis

Sepsis is a life-threatening systemic response to an infection. This article provides an overview of sepsis, including stages, diagnosis and treatment.

Sepsis Diagnosis

Causes and Symptoms of Sepsis in Newborns

Diagnosis and Treatment of Sepsis in Newborns

Sepsis Prevention

Recovering from Sepsis

Sepsis Epidemiology

Sepsis Pathophysiology

Sepsis at the Molecular Level

Sepsis and Pregnancy

Sepsis: Identifying the Signs and Administering First Aid

Acute Respiratory Distress Syndrome (ARDS) and Sepsis

See more featured articles »

Sepsis Complications and Prevention

The Stages of Sepsis

How Antimicrobial Resistance Amplifies the Burden of Sepsis

Lactate Levels and Sepsis

Sepsis and Influenza

Sepsis History

The Development of a Sepsis Scoring System in a Murine Model

Latest Sepsis News and Research

PLK1-mTOR axis may be a promising therapeutic target for sepsis, study suggests

Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction.

26 Jan 2023

Study compares early restrictive and liberal fluid management for sepsis-induced low pressure

Vanderbilt University Medical Center had a leading role in a large national study designed to compare two early interventions in the treatment of patients with sepsis, the body's severe response to an uncontrolled infection.

24 Jan 2023

High adherence to procalcitonin-guided antibiotic prescribing guideline may reduce antibiotic use in hospitals

A study published in the journal BMC Infectious Diseases claims that high adherence to procalcitonin-guided antibiotic prescribing guidelines is necessary to reduce antibiotic use in patients with suspected lower respiratory tract infections.

23 Jan 2023

UQ researchers identify a cellular pathway to reprogram the body’s immune system

University of Queensland researchers have identified a pathway in cells that could be used to reprogram the body's immune system to fight back against both chronic inflammatory and infectious diseases.

18 Jan 2023

Upregulation of Robo4 expression reduces mortality from severe infection

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression.

18 Jan 2023

Next-generation light-activated nanotech can eradicate antibiotic-resistant superbugs

It's 'lights out' for antibiotic-resistant superbugs as next-generation light-activated nanotech proves it can eradicate some of the most notorious and potentially deadly bacteria in the world.

16 Jan 2023

Endothelial cell-specific protein Robo4 reduces mortality in severe infection

Pipes play an essential role in bringing water to the faucets in your home, but if one of those pipes springs a leak, damage can result.

16 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023

Clinically relevant biomarker strategies in drug development

In this interview, NewsMedical speaks with Dr. Justin Devine and Dr. Nicholas Woudberg about biomarkers, their importance for drug development as well as the potential they have when it comes to machine learning.

From Synexa Life Sciences BV 9 Jan 2023

The risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population

Researchers evaluated the outcomes and identified risk factors associated with the development of ARDS after SARS-CoV-2 infections among young adults.

6 Jan 2023

Is appropriate initial empirical antimicrobial therapy associated with lower in-hospital mortality in patients with bloodstream infections?

Researchers estimated the association between the receipt of appropriate initial empirical antibiotic treatment and in-hospital death among individuals hospitalized with BSI (bloodstream infections).

6 Jan 2023

Analyzing electronic medical records to identify COVID-19 sequelae

In a recent study published in the journal Emerging Infectious Diseases, researchers analyzed and compared pre‒ and post‒COVID-19 diagnostic codes to identify symptoms that had higher encounter incidence in the post‒COVID-19 period as sequelae. COVID-19 sequelae and future emerging diseases can be generated and monitored using this method.

3 Jan 2023

ER doctors call private equity staffing practices illegal and seek to ban them

A group of emergency physicians and consumer advocates in multiple states are pushing for stiffer enforcement of decades-old statutes that prohibit the ownership of medical practices by corporations not owned by licensed doctors.

22 Dec 2022

Inside a children’s hospital: Struggling to cope with a surge of respiratory illness

Waiting for their turn in the emergency room, dazed-looking parents in winter coats bounced crying children in their arms, trying to catch the eye of Dr. Erica Michiels. Us! Pick us next! they seemed to plead with tired eyes.

20 Dec 2022

Antibody discovery could explain why so many group A strep vaccines have failed

Researchers at Lund University in Sweden have discovered an antibody with the potential to protect against Strep A infection, as well as a rare form of antibody binding, that leads to an effective immune response against bacteria.

12 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

Antibodies against gentamicin associated with increased risk of type 1 diabetes in children

Antibodies produced against the commonly used antibiotic, gentamicin, appear to increase the risk of type 1 diabetes in children already genetically at risk, scientists say.

8 Dec 2022

Using AI and socially assistive robots for early detection of urinary tract infections

A team of researchers from the University of Edinburgh and Heriot-Watt University are developing artificial intelligence (AI) and socially assistive robots to detect urinary tract infections (UTIs) earlier.

2 Dec 2022

Effects of early postnatal exposure to antibiotics on incidence of early-onset sepsis

Researchers investigated the effects of early postnatal antibiotic exposure among infants in the participating networks of high-income countries.

30 Nov 2022

Study reports high rates of complications, rehospitalizations among patients undergoing abdominal ostomy surgery

Patients undergoing abdominal surgery for ostomy placement have high rates of hospital readmissions and emergency department visits – often involving ostomy-related complications, reports a study in the November/December issue of the Journal of Wound, Ostomy and Continence Nursing, the official journal of the Wound, Ostomy and Continence Nurses Society.

29 Nov 2022