Sepsis

Sepsis is a life-threatening illness. Your body's response to a bacterial infection usually causes it. Your immune system goes into overdrive, overwhelming normal processes in your blood. The result is that small blood clots form, blocking blood flow to vital organs. This can lead to organ failure. Babies, old people and those with weakened immune systems are most likely to get sepsis. But even healthy people can become deathly ill from it.

Everything You Need To Know About Sepsis

Sepsis is a life-threatening systemic response to an infection. This article provides an overview of sepsis, including stages, diagnosis and treatment.

Diagnosis and Treatment of Sepsis in Newborns

Sepsis History

Causes and Symptoms of Sepsis in Newborns

Acute Respiratory Distress Syndrome (ARDS) and Sepsis

Sepsis Prevention

Sepsis Pathophysiology

Lactate Levels and Sepsis

Sepsis Epidemiology

Sepsis Diagnosis

How Antimicrobial Resistance Amplifies the Burden of Sepsis

Sepsis: Identifying the Signs and Administering First Aid

See more featured articles »

The Stages of Sepsis

Sepsis at the Molecular Level

Sepsis and Influenza

Recovering from Sepsis

Sepsis Complications and Prevention

The Development of a Sepsis Scoring System in a Murine Model

Sepsis and Pregnancy

Latest Sepsis News and Research

New study links inherited mitochondrial DNA mutation to disrupted immune balance

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death.

26 Nov 2025

Infection-related hospital stays linked to higher risk of developing dementia

A new research paper was published in Volume 17, Issue 10 of Aging-US on October 13, 2025, titled "Hospitalization with infections and risk of Dementia: a systematic review and meta-analysis."

25 Nov 2025

Lung to gut movement of hospital-acquired bacterium raises the risk of sepsis

A hospital-acquired bacterium that causes serious infections can move from the lungs to the gut inside the same patient, raising the risk of life-threatening sepsis, new research reveals.

25 Nov 2025

Simple hospital program reduces severe maternal infections by 32%

The APT-Sepsis program significantly reduced infection-related outcomes in maternal care, demonstrating the impact of coordinated interventions in hospitals.

24 Nov 2025

C-reactive protein shows stronger accuracy for early-onset sepsis in preterm newborns

Neonatal EOS, a severe bloodstream infection that strikes within the first three days of life, is a major cause of infant illness and death worldwide.

20 Nov 2025

Structured infection prevention program can save mothers’ lives in low-resource settings

A landmark multi-country clinical trial has shown that a structured, sustainable approach to infection prevention and treatment can save women's lives, cutting severe maternal infections and deaths by about one-third (32%) compared to usual care.

19 Nov 2025

Researchers develop new method to combat antibiotic-resistant bacteria using bacteriophages

Antibiotic resistance is one of the most pressing challenges to global public health as harmful microbes evolve to evade these medications.

19 Nov 2025

Study uncovers how tumors exploit a molecular signal to exhaust T cells

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them-and how silencing that signal could revive the body's immunity.

17 Nov 2025

Scientists invent new method for manufacturing platelet-producing cells from stem cells

Platelets are small, disc-shaped cell fragments in the blood that are essential to stop bleeding and to initiate blood clotting after injury.

13 Nov 2025

Potential breakthrough in treating acute kidney injury with ceramide-targeting drugs

Serious damage to short-term kidney function-known as acute kidney injury, or AKI-can be fatal and also increase the risk of irreversible chronic kidney disease. It can be triggered by stressors ranging from sepsis to heart surgery, and it affects more than half of ICU patients.

12 Nov 2025

Earlier blood transfusion reduces heart complications post-surgery in high-risk patients

An earlier blood transfusion- done when hemoglobin levels were higher - after major general or vascular surgery among people with heart disease was associated with a lower risk of some complications but not the most severe ones, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

11 Nov 2025

Weaning hospitalized patients from dialysis may restore kidney function

Weaning patients with acute kidney injury (AKI) from dialysis while they are still hospitalized may save them from remaining on the treatment for the rest of their lives, according to a new study led by UC San Francisco.

7 Nov 2025

Evolving epidemiology of invasive Group A Streptococcus in critical care

Streptococcus pyogenes or invasive Group A Streptococcus (iGAS) is a major clinical concern around the world, since iGAS infections can quickly escalate into life-threatening conditions such as necrotizing fasciitis, septic shock, and pneumonia.

6 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

Novel vaccine strategy could solve the challenge of implanted device infections

Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but significant risk that these devices get infected with bacterial pathogens.

4 Nov 2025

Understanding how biological sex and gender inequities contribute to suboptimal sepsis treatment

Sepsis continues to be a leading cause of mortality in ICUs worldwide. Despite advances in early detection and treatment, standardized antibiotic dosing frequently ignores patient-level variability-especially that associated with sex-related physiology and gender-influenced care disparities.

31 Oct 2025

Understanding the role of m6A methylation in acute lung injury pathogenesis

Acute lung injury (ALI) is a critical clinical condition characterized by diffuse inflammation of the lung parenchyma and intractable hypoxemia, typically caused by factors, such as trauma, pneumonia, shock, and sepsis.

30 Oct 2025

E. coli in retail meat linked to thousands of urinary infections

Research reveals a significant link between E. coli in meat and urinary tract infections, particularly in vulnerable communities in Southern California.

28 Oct 2025

Leveraging the microbiome to promote healthy living and aging

From probiotic pills to skincare products to dedicated meal plans, the microbiome is all the rage in the health and wellness space.

21 Oct 2025

New AI system connects hidden clues in medical records to transform diagnosis

Doctors often must make critical decisions in minutes, relying on incomplete information. While electronic health records contain vast amounts of patient data, much of it remains difficult to interpret quickly-especially for patients with rare diseases or unusual symptoms.

15 Oct 2025