Retrovirus-based vectors used in gene and cell therapies may be characterized with light scattering instruments and separations systems from Wyatt Technology.
Image Credit: ShuterStock/Kateryna Kon
Lentivirus and gamma retrovirus are two extremely popular retrovirus-based vectors currently being developed for novel gene and cell therapies. As of 2021, there were over three hundred products in clinical trials.
Accurate quantitation with comprehensive and reliable characterization is essential for ensuring the quality and efficacy of retroviral gene vectors. However, the inherent complexity of these products leads to significant analytical challenges. This application note from Wyatt Technology describes two technologies for biophysical characterization of viral vectors based on light scattering: high-throughput dynamic light scattering (HT-DLS) for quantitation and screening, and field-flow fractionation coupled to multi-angle light scattering (FFF-MALS) for in-depth characterization.
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About Wyatt Technology
With a long history of excellence in scientific instrumentation, Wyatt Technology is the recognized leader in innovative light scattering instruments, accessories and software for determining the properties of macromolecules and nanoparticles in solution. Wyatt's cutting-edge solutions determine the size, physical titer, payload and zeta potential of nanoparticles, as well as the molar mass, size, conformation, conjugation and interactions of macromolecules. With a staff composed of 25% Ph.D. scientists and many more dedicated and experienced support personnel, Wyatt's aim is to delight its customer with the best products, training, customer support and service available in the industry.
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