USPTO issues patent related to Seattle Genetics' ADC technology

Seattle Genetics, Inc. (Nasdaq: SGEN) announced today that the U.S. Patent and Trademark Office has issued a patent related to its antibody-drug conjugate (ADC) technology. U.S. Patent No. 7,659,241 covers cleavable linkers and potent auristatin drug payloads used in certain of Seattle Genetics’ ADC programs, most notably brentuximab vedotin (SGN-35), as well as many ADC programs in development by its collaborators. Brentuximab vedotin, an ADC that utilizes the vcMMAE drug-linker unit, is in a pivotal trial for relapsed and refractory Hodgkin lymphoma and a phase II trial for relapsed and refractory systemic anaplastic large cell lymphoma. The company anticipates submitting a New Drug Application for brentuximab vedotin in the first half of 2011.

“This patent is an important addition to the intellectual property portfolio surrounding our ADC technology, and significantly enhances the patent position for multiple internal and collaborator programs that use the vcMMAE drug-linker unit”

“This patent is an important addition to the intellectual property portfolio surrounding our ADC technology, and significantly enhances the patent position for multiple internal and collaborator programs that use the vcMMAE drug-linker unit,” said Eric Dobmeier, Chief Business Officer of Seattle Genetics. “Issuance of this patent, which extends protection in the United States to at least 2025, also reflects the culmination of significant and novel research conducted at Seattle Genetics to continue advancing our industry-leading ADC technology.”

ADCs utilize the targeting ability of monoclonal antibodies to deliver potent, cell-killing payloads to specific cells. Seattle Genetics’ proprietary technology employs synthetic, highly potent drugs attached to antibodies through stable linker systems. The linkers are designed to release the drug payload only under specific conditions once inside target cells, thereby sparing non-target cells many of the toxic effects of traditional chemotherapy.

Seattle Genetics is developing brentuximab vedotin in collaboration with Millennium: The Takeda Oncology Company, under which Seattle Genetics has U.S. and Canadian commercialization rights and Millennium has exclusive rights to commercialize the product in the rest of the world. Seattle Genetics and Millennium are jointly funding worldwide development costs for brentuximab vedotin on a 50:50 basis. Additionally, Seattle Genetics has nine ongoing ADC collaborations with leading biotechnology and pharmaceutical companies. To date, Seattle Genetics has generated approximately $110 million through ADC technology license agreements.

Source:

Seattle Genetics, Inc.

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