Novel method achieves accurate and precise temperature estimation in fat-containing tissues

NewsGuard 100/100 Score

Magnetic resonance thermometry (MRT) is the only imaging technique that noninvasively provides temperature distribution in vivo. The water proton resonance frequency shift (PRFS)-based method is the most popular choice for MR temperature monitoring in aqueous tissues.

A research team led by Prof. ZHENG Hairong from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences developed a "dual-step iterative temperature estimation (DITE)" method for fat-referenced PRFS temperature imaging in fat-containing tissues.

In mammals, there are two types of adipose (i.e., fat-containing) tissue: white adipose tissue (WAT) and brown adipose tissue (BAT).

"WAT stores excess energy as triacylglycerol, whereas BAT burns fat to dissipate energy in the form of heat after activation and is now considered to be the next potential therapeutic target for metabolic syndrome" said ZHENG.

The proposed DITE method achieved accurate and precise temperature estimation compared with the results measured by the fluorescent thermometer, a common method and a golden standard of measuring temperature.

The average mean error, standard deviation, and root mean squared error were -0.08°C, 0.46°C and 0.56°C, respectively, within the region of interest (ROI) around the thermometer in the ex vivo BAT using a water bath experiment. The method can provide a potential imaging tool for the characterization of brown adipose tissue in vivo.

Prof. ZHENG said, "In the future, we will apply this method to monitor the temperature in BAT in vivo and characterize BAT activity using this temperature imaging technique."

By modulating BAT activity, this study provides crucial insight relevant to the treatment of metabolic diseases such as diabetes, obesity, and non-alcoholic fatty liver disease.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study finds accounting for sex improves precision and prognostic performance of CMR biomarkers for heart failure