Inflammation in mid-life as a predictor of mobility decline in older age

In a recent study published in the Journal of the American Geriatric Society, having high inflammation in mid-life was associated with a clinically meaningful slower gait speed-;an indicator of mobility-;20 years later.

In the study, which included 4,758 community-dwelling adults, the link between high inflammation and slower late-life gait speed was especially strong for people with sustained high inflammation over the 20-plus years of follow-up. The association was evident even among the healthiest adults who never experienced other common conditions such as obesity, hypertension, or diabetes.

These findings suggest that monitoring inflammation has the potential to be important for late life health, similar to monitoring routine health metrics such as blood pressure and glucose."

B. Gwen Windham, MD, MHS., corresponding author

Journal reference:

Parker, K. G., et al. (2024) Associations of mid-to-late-life inflammation with late-life mobility and the influences of chronic comorbidities, race, and social determinants of health: The Atherosclerosis Risk in Communities StudyJournal of the American Geriatrics Society.


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