Become CCS-Aware! The benefits of Trapped Ion Mobility Spectrometry (TIMS) and Collisional Cross Section (CCS) for Molecular Characterization in Drug Discovery and Development.
Bruker’s timsTOF platforms measure ion mobilities using first principles for all analytes, assigning collisional cross section (CCS) values for small molecules, metabolites, lipids, peptides, and proteins. Experiments are enhanced with the 4th dimensional CCS value - improving the fidelity of protein and peptide assignments, more accurate quantification and isotope matching with improved S/N, deciphered isomeric species, as well as many CCS predictive tools to assist in molecular confirmation and unknown ID.
Run time: 3:00 mins
Michael Greig, Dir. Pharma/Biopharma Americas, Bruker Daltonics discusses CCS and Benefits of TIMS
Video Credit: Bruker Life Sciences Mass Spectrometry