Real-Time Evaluation of Necrosis and Apoptosis

Cell death is crucial for multicellular homeostasis, but it also plays an ill-fated role in human disorders. For treating neurodegeneration or cancer, discovery of targeted cytoprotective and cytotoxic agents are critical.

It is vital to describe the pattern of cell death and response kinetics in order to understand the dysregulation in a disease mechanism as well as responses to experimental stimuli. Conventional experimental methods to determine the type of cell death are usually tedious, costly, and inadequate.

The novel RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay from Promega is explained here. The method offers the ease of an add-mix-measure method in a real-time and live-cell format.

The CLARIOstar microplate reader with atmospheric control unit (ACU) gives the sensitive recognition of duplexed fluorescent and luminescent signals. It also upholds appropriate [CO2] and [O2] environment for cell culture. Once optimized, this grouping permits the conduct of the assay in auto-mode. It rules out the chance of omitting important cellular responses irrespective of when they occur.

Read the full article including the methods, results and discussion.

Real-Time Assessment of Apoptosis and Necrosis

About BMG Labtech

BMG LABTECH has been committed to producing microplate readers for more than twenty years. By focusing on the needs of the scientific community, the company’s innovative microplate readers have earned the company the reputation of being a technology leader in the field.

BMG LABTECH has developed a wide range of dedicated and multi-mode microplate readers for life sciences applications and high-throughput screening.

All BMG LABTECH microplate readers are "Made in Germany" and are conceived, developed, assembled, and tested entirely at our headquarters in Germany.

Since our establishment in Offenburg, Germany in 1989, BMG LABTECH has expanded to offer a worldwide sales and support network with offices in the USA, UK, Australia, Japan and France. Our subsidiaries, regional offices and distributors are committed to bringing you innovative microplate reader technology with the quality and reliability you expect from a German company.

Our staff includes engineers and scientists from the fields of biology, biochemistry, analytical chemistry, and physics.

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Last updated: Feb 1, 2020 at 3:09 PM


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