Neuron Markers for Serotonergic Neurons

The following article presents more information about the most frequently used serotonergic neuron markers.

The neurotransmitter serotonin (5-HT) is found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS). It is synthesized by the serotonergic neurons.

Tryptophan Hydroxylase (TPH)

The TPH is an enzyme involved in the synthesis of serotonin. It has two isoforms TPH1 and TPH2. The latter is found mainly in the brain.

Serotonin Transporter (SERT)

SERT stands for serotonin transporter. It is a transmembrane protein with the help of which the re-uptake of 5-HT from the synaptic cleft into the presynaptic neuron is possible.​


​Serotonin Transporter Inhibitors

Product Activity
Desvenlafaxine (ab145741) Potent SERT and NET inhibitor.
Potent SERT and norepinephrine transporter (NET) inhibitor.
Nisoxetine hydrochloride (ab141134) Potent SERT and NET inhibitor.
Duloxetine (ab143249) Dual NET and SERT inhibitor.
Venlafaxine hydrochloride (ab120715) Selective NET and SERT inhibitor.



Pet1 is a crucial transcription factor that is responsible for the transcription of genes that are important for the metabolism, as well as for the reuptake of serotonin.

References and Further Reading

  • Deecher, D. C. et al. Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor. J. Pharmacol. Exp. Ther. 318, (2006).
  • Hendricks, T. J. et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37, 233–247 (2003).
  • Kittler, K., Lau, T. & Schloss, P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. Eur. J. Pharmacol. 629, 63–67 (2010).
  • Liu, C. et al. Pet-1 is required across different stages of life to regulate serotonergic function. Nat. Neurosci. 13, 1190–1198 (2010).
  • Zhou, J. Norepinephrine transporter inhibitors and their therapeutic potential. Drugs Future 29, 1235–1244 (2004).

About Abcam

Abcam is a global life sciences company providing highly validated antibodies and other binders and assays to the research and clinical communities to help advance the understanding of biology and causes of disease.

Abcam’s mission is to serve life scientists to help them achieve their mission faster by listening to their needs, continuously innovating and improving and by giving them the tools, data and experience they want. Abcam’s ambition is to become the most influential life science company for researchers worldwide.

Sponsored Content Policy: publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.

Last updated: Jan 30, 2020 at 5:39 AM


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Abcam. (2020, January 30). Neuron Markers for Serotonergic Neurons. News-Medical. Retrieved on March 01, 2024 from

  • MLA

    Abcam. "Neuron Markers for Serotonergic Neurons". News-Medical. 01 March 2024. <>.

  • Chicago

    Abcam. "Neuron Markers for Serotonergic Neurons". News-Medical. (accessed March 01, 2024).

  • Harvard

    Abcam. 2020. Neuron Markers for Serotonergic Neurons. News-Medical, viewed 01 March 2024,

Other White Papers by this Supplier