This article provides an introduction to dynamin and endocytosis and lists the inhibitors that are relevant to research.
Dynamin is an important GTPase enzyme that takes part in different endocytotic processes. It has three major isoforms, and each of these is composed of four primary domains with different functions.
Another major role played by dynamin is in the regulation of the cell cycle. It also has a crucial role in the way centrosomes cohere and in cytokinesis.
Dynamin inhibitors are molecules that inhibit the action of different domains of the dynamin enzyme, and thus prevent the occurrence of endocytosis. They have found wide uses in such areas as the study of the pathways of cell signaling, the cell cycle, cell division, and illnesses such as cancer, infectious diseases, including botulism and HIV, and neurological conditions.
The following is a list of the dynamin inhibitors available:
A Summary of Dynamin Inhibitor Activity
The following table shows how dynamin inhibitors work via different mechanisms:
- Hill TA et al. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem 53:4094-102 (2010).
Read more (PubMed: 20426422)
- Hill TA et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem 25:3762-73 (2009).
Read more (PubMed: 19459681)
Recommended Resources from Our Technical Team
- Granseth B et al. Clathrin mediated endocytosis: the physiological mechanism of vesicle retrieval at hippocampal synapses. J Physiol 15:681-6 (2007).
Read more (PubMed: 17599959)
- Mettlen M et al. Dissecting dynamin's role in clathrin-mediated endocytosis. Pharmacol Ther 47:233-66 (2009)
Read more (Pubmed: 1975444)
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