The homeostatic plasticity of a neuron refers to the ability of neurons to regulate the level of excitement they experience relative to the activity of the network they are part of. This process is highly complicated and occurs over a relatively long timescale (days).
The mechanism by which homeostatic plasticity occurs is not fully understood and research into this is ongoing. To carry out research into plasticity neurons can be induced via a neuronal firing rates method.
In the below video this protocol is explored in detail and we see how Abcam’s products (Tetrodotoxin Citrate and (R,S)-3,5-DHPG) play an important role.
The video explains how researchers can:
- Bolus load astrocytes with a Ca2+ indicator
- Prepare acute hippocampal slices
- Record astrocytic activity (both Gq GPCR agonist-evoked and spontaneous) in hippocampal slices
Abcam is a global life sciences company providing highly validated antibodies and other binders and assays to the research and clinical communities to help advance the understanding of biology and causes of disease.
Abcam’s mission is to serve life scientists to help them achieve their mission faster by listening to their needs, continuously innovating and improving and by giving them the tools, data and experience they want. Abcam’s ambition is to become the most influential life science company for researchers worldwide.
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