The process of epithelial to mesenchymal transition (EMT) plays a key role in metastasis. Vimentin is a clinical marker of metastasis and a canonical marker of the EMT. The overexpression of vimentin in epithelial cancers such as breast, lung, and prostate makes it a viable target for cancer therapy.1,2
How Abcam Can Help Users
By offering a tailored and flexible method through a secure source of research tools and custom services, Abcam can assist users to achieve their goals related to vimentin research.
Vimentin recombinant rabbit monoclonal antibody (ab92547) staining in human ovarian cancer tissue using immunohistochemistry (formaldehyde-fixed, paraffin-embedded sections). Image courtesy of Mr Carl Hobbs, Kings College London.
Flexible Antibody Formulations
Antibodies against EMT-related proteins and vimentin come in PBS-only formulations and are conjugated to enzymes and fluorophores.
Comprehensive Range of Vimentin and EMT-Related Products
Antibodies and tiny molecules specific for studying vimentin from all angles and targeting all EMT stages are available.
Custom Antibody Services
Using Abcam’s patented RabMAb® technology, users can create rabbit monoclonal antibodies against their target of interest.
Large Amounts and Consistency of Supply
Users can secure the supply of their preferred products.
Custom miRNA Profiling
These are profile miRNAs that control cancer metastasis with Abcam’s Firefly particle technology. Abcam provides custom miRNA panel design to provide users with an assay customized to their requirements.
If a specific product is not available, users can contact Abcam. The company’s expert customer services team will assist them with their particular request.
- Kidd, M. E., Shumaker, D. K. & Ridge, K. M. The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer. Am. J. Respir. Cell Mol. Biol. 130827094923003 (2013). doi:10.1165/rcmb.2013-0314TR
- Satelli, A. & Li, S. Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell. Mol. Life Sci. 68, 3033–3046 (2011).
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