Chromatography News and Research

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Chromatography in Greek means to ‘write with colors.’ It is a versatile separation technique developed in 1903 by Mikhail Tswett, a Russian botanist. He separated colorful plant pigments using a column of calcium carbonate. Ever since its discovery, chromatography has evolved as a powerful tool in the lab for the separation and identification of different compounds in a mixture.

Trial identifies 4 grams a day as the tested safe level for L-tyrosine in healthy men

A randomized, crossover trial in healthy adult men found that 4 weeks of L-tyrosine supplementation at doses up to 4 g/day did not cause clinically meaningful changes in safety markers, diet, blood pressure, or body measures. The highest tested dose, 4 g/day, was identified as the no-observed-adverse-effect level under the study’s four-week conditions, although broader and longer-term studies are still needed.

23 Jun 2026

Optimized proximity labeling platform tracks cellular protein communication networks

The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.

22 Jun 2026

PMOS rethink reframes a common hormone disorder as a whole-body disease

A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment.

18 Jun 2026

Gut bacteria may help explain why fatigue appears before illness

A small study of healthy Japanese adults found that fatigue was associated with distinct gut microbiome, microbial gene, and fecal metabolite patterns. The findings suggest fatigue may track with altered microbial energy metabolism and oxidative stress-related functional potential, but larger longitudinal studies are needed to test causality and clinical value.

16 Jun 2026

Urine drug test may boost adherence to blood pressure medications

The largest ever UK trial of a urine test used across the NHS to spot when patients skip their medication has shown it may improve adherence to treatment.

12 Jun 2026

Advancing Cushing's syndrome diagnosis with salivary cortisone testing

Discover expert insights into Cushing's syndrome diagnosis using salivary cortisone testing and LC-MS/MS for improved accuracy.

From Waters Advanced Diagnostics 10 Jun 2026

Untargeted metabolomics approach identifies potential biomarkers for latent tuberculosis diagnosis

Announcing a new article publication in BIO Integration. Latent tuberculosis infection (LTBI) is difficult to diagnose due to the lack of a definitive gold standard.

5 Jun 2026

Southwest Research Institute evaluates NASA's medication handling practices

Southwest Research Institute evaluated NASA's medication handling practices, which currently call for removing medications from their original packaging and storing them in resealable plastic bags.

2 Jun 2026

Urine-based autism screening using gut microbial metabolites

Elevated gut microbe metabolites may distinguish children with autism, paving the way for a non-invasive urine test and a new ASD subtype linked to microbiome.

29 May 2026

Gut changes linger years after polyp removal and may signal colorectal cancer risk

Researchers found that women who had undergone colorectal adenoma resection still showed gut microbiome and fecal metabolome alterations an average of about 12 years later. These persistent changes partly resembled colorectal cancer-associated patterns, suggesting that the host-microbiome axis may remain altered along the adenoma-cancer continuum.

28 May 2026

Retatrutide reshapes metabolism in obesity and type 2 diabetes, study finds

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

26 May 2026

Yoga and meditation show promise for gut health

This systematic review found that yoga and Buddhist meditation were associated with favorable gut microbiota and metabolite profiles in four human studies involving healthy adults. However, because participants largely followed vegetarian or vegan diets and no randomized controlled trials were included, the findings cannot prove that meditation alone reshapes the gut microbiome.

24 May 2026

Bioinformatics accelerates discovery of marine-derived bioactive therapeutic peptides

Marine organisms have evolved a remarkable arsenal of host-defense peptides under conditions of extreme variability and constant pathogen exposure. Generally defined as short chains of 2 to 20 amino acid residues, these molecules have become a focal point for biomedicine, food science, and materials science.

22 May 2026

What medicine-exposed rats reveal about the next urban zoonotic threat

Researchers found that more than half of urban rats sampled from low-income communities in Salvador, Brazil, carried active pharmaceutical ingredients in their brain tissue. These pollutants were associated with altered zoonotic infection patterns, including lower Leptospira infection probability in rats carrying azithromycin and higher Capillaria infection probability in rats carrying citalopram.

22 May 2026

Chia seeds may boost fetal brain DHA during obesity-linked pregnancy

Chia seed supplementation during pregnancy increased maternal omega-3 long-chain fatty acids, including DHA, in a rat model of high-fat-high-sugar diet-induced obesity. The findings suggest plant-derived ALA from chia seeds may improve maternal, placental, and mid-gestation fetal brain lipid profiles, but human relevance and offspring outcomes still need testing.

17 May 2026

Gut microbes may reveal why diabetes raises heart disease risk

Integrated gut microbiome and plasma metabolomics profiling identified distinct microbial and metabolic signatures in people with T2DM and T2DM-CAD. In a small exploratory cohort, Bacteroides sp._CAG_875 and 12-ketoLCA emerged as candidate markers that may help distinguish diabetic patients with coronary complications, pending larger validation.

13 May 2026

Researchers uncover sex-specific metabolic patterns in ocular tissues

As a highly differentiated sensory organ, the maintenance of the eye's physiological functions relies on rigorous metabolic regulation.

11 May 2026

What labs need to know about PFAS and ultrapure water quality

This interview with PFAS specialists reveals how ultrapure water impacts lab accuracy.

From Sartorius Lab Instruments GmbH & Co. KG 6 May 2026

CDC HoSt-TT certification for Siemens Healthineers total testosterone test expands patient access to gold standard equivalent results

Siemens Healthineers announced its Atellica IM Testosterone II (TSTII) assay has achieved certification through the Centers for Disease Control and Prevention (CDC) Hormone Standardization Program for Total Testosterone (HoSt-TT).

From Siemens Healthineers 5 May 2026