New clinical trial findings suggest that thousands of women who have a family history of breast cancer should be screened from the age of 35, rather than the current eligibility age of 40.
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The findings, which were gathered from 34 screening centers, suggest that changing the age of screening to 35 would enable tumors to be detected at an earlier stage, potentially saving thousands of lives.
We believe these findings could be practice-changing and urge the Government’s upcoming review of NHS screening programmes to set out what further evidence is needed to consider screening for women aged 35 to 39 who are at increased familial risk of breast cancer.”
Baroness Delyth Morgan, Breast Cancer Now
As reported in the journal EClinicalMedicine, Professor Gareth Evans (University of Manchester) and colleagues conducted a trial of almost 3,000 women aged 35 to 39 with a family history of breast cancer.
The women, who were at a moderate-to high-risk of developing the disease were offered annual screening between 2006 and 2015.
Evans and team report that a total of 50 breast cancers were detected. Thirty-five of them were found to be invasive and 80% of those tumors were detected while they were 2cm or smaller. One-fifth of the invasive cancers had spread to the lymph nodes.
These findings were then compared to those from a cohort of aged-matched women at the same risk level who did not have screening, which demonstrated that the annual screening had resulted in a doubling of the number of tumors being detected at 2cm or less.
Among the unscreened cohort, only 45% of tumors were detected at this small size and 54% of them had reached the lymph nodes.
Leading researchers say changing the screening eligibility age to 35 could benefit as many as 86,000 women per year in the UK.
These are the first significant data on the benefits of screening in women aged 35-39. Our trial shows that mammography screening is effective in detecting tumors earlier in this younger age group, and lays the groundwork for extending this screening in women at moderate or high risk down to women aged 35-39 from ages 40-49.”
Professor Gareth Evans, Lead Researcher
Despite more women now surviving breast cancer than ever before, the disease is still the most common cancer in the UK, with approximately 55,000 women and 350 mean diagnosed every year. Estimates suggest that up to 15% of these new cases are associated with a family history of the condition.
Evans says further research is now needed to investigate the impact that the new screening age may have on women’s overall survival.
Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35–39 at Increased Familial Risk of Breast Cancer. EClinicalMedicine. 10 February 2019.