Across typical brain organoid processes, automation minimizes manual intervention from roughly 27 hours per week for 10 plates to about three hours. This allows laboratories to recover weeks of skilled researcher time over extended differentiation timelines while ensuring the creation of functional, highly physiologically-relevant brain organoids.
Automated culturing
Differentiating brain organoids from iPSCs is traditionally time-intensive and variable, demanding months of meticulous hands-on effort to ensure robust organoid production. The CellXpress.ai® Automated Cell Culture System revolutionizes this process through complete automation, minimizing manual labor and boosting model consistency. This allows skilled scientists to be redeployed to other tasks - and ensures reproducible model generation which increases the robustness of downstream assays.
Customer challenges addressed
- Excessive hands-on time slows research: Automation reduces manual involvement, allowing researchers to focus on more important tasks.
- Human-introduced variability compromises reproducibility: AI-powered standardized processes provide consistent, repeatable outcomes.
- Manual routine tasks and subjective judgment increase errors: Machine-learning-enabled decision-making eliminates operator-dependent stages to ensure dependable execution.
- Siloed instruments and software create operational drag: Unified instrumentation and software streamline each phase of the culture workflow and speed up time to insight.
- Scaling brain organoid research is limited by steps that were previously difficult to automate: Integrated rocking incubation delivers continuous nutrient flow and motion, making long-term organoid development standardized, reproducible, and scalable.
Weekly hands-on time: Brain organoid culture (representative scale). Source: Molecular Devices UK Ltd
| Task |
Manual workflow (10 plates) |
The CellXpress.ai system: hands-on time |
| Work area and media preparation |
3.5 hours/week |
~0.6 hours/week |
| Feeding |
6 hours/week |
Included |
| Imaging and monitoring |
17.5 hours/week |
0 |
| Total weekly hands-on time |
27 hours/week |
3 hours/week |
Integrated automation for brain organoid culture
By integrating liquid handling, incubation, imaging, and rocking incubation into a single platform, the CellXpress.ai system streamlines iPSC maintenance, cell aggregation, media exchange, and continuous agitation.
Daily whole-well imaging and longitudinal monitoring minimize operator-dependent variability and facilitate consistent organoid development.
About Molecular Devices UK Ltd
Molecular Devices is one of the world’s leading providers of high-performance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. Molecular Devices is committed to the continual development of innovative solutions for life science applications. The company is headquartered in Silicon Valley, California, with offices around the globe. For more information, please visit www.moleculardevices.com.
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