VEGFs and their receptors: Key mediators in the nervous and vascular systems

Vascular endothelial growth factors, or VEGFs, constitute a class of secreted polypeptides that exhibit angiogenic and mitogenic activities. Due to the significance of VEGFs and receptors in tumorigenesis, angiogenesis and neuroprotection, they are attractive targets for drug development.

The members of the VEGF family — VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PlGF — bind in particular patterns to three associated receptor protein tyrosine kinases, namely, VEGFR1/FLT1, VEGFR2/KDR and VEGFR3/FLT4.

They also bind in specific patterns with neuropilin-1 (NRP1) and neuropilin-2 (NRP2) — two non-tyrosine kinase transmembrane proteins.

The ligand-receptor binding stimulates the formation of homomeric and heteromeric receptor complexes and triggers downstream signaling.

Apart from VEGF signaling, neuropilins also serve as co-receptors to various other signaling pathways, such as those induced by Hepatocyte Growth Factor (HGF), Epidermal Growth Factor (EGF), Platelet-Derived Growth Factor (PDGF), Fibroblast Growth Factor (FGF), Transforming Growth Factor beta (TGFβ) and Insulin-like Growth Factor (IGF).

VEGF family ligands and receptors

Sino Biological offers more than 65 recombinant VEGF and receptor proteins encompassing all members of the VEGF family and various isoforms of VEGF. A huge majority of these recombinant proteins are expressed in eukaryotic cells (insect cells or human cells), thereby ensuring accurate modification and higher activity of proteins.

High activity

Cell proliferation assay using human umbilical vein endothelial cells (HUVEC).

Cell proliferation assay using human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.

Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC).

Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.

Recommended recombinant VEGF and receptor proteins

Source: Sino Biological Inc.

Cat# Molecule Species Activity Tag
10136-H02H VEGFR1/FLT-1 Human Active hFc
10136-H08H VEGFR1/FLT-1 Human Active His
10136-H08H1 VEGFR1/FLT-1 Human Active His
10806-H02H VEGFR3/FLT4 (ECD) Human Active hFc
50584-M02H VEGFR3/FLT-4 Mouse Active hFc
10012-H02H VEGFR2/KDR Human Active hFc
10012-H02H1 VEGFR2/KDR (Domain 1&2&3) Human Active hFc
10012-H02H1-B VEGFR2/KDR (Domain 1&2&3) Human   hFc
10012-H02H2 VEGFR2/KDR (Domain 2&3) Human Active hFc
10012-H08H2 VEGFR2/KDR (Domain 2&3) Human   His
10012-H20B1 VEGFR2/KDR Human Active GST &
His
50998-M08H-B VEGFR2/KDR Mouse Active His
80113-R02H VEGFR2/KDR Rat Active hFc
80113-R08H VEGFR2/KDR Rat   His
90907-C08H VEGFR2/KDR Cynomolgus   His
10011-H08H NRP1 Human Active His
10695-H02H NRP2 Human Active hFc
11066-HNAB-B VEGF165 Human,
Cynomolgus
  Native
11066-HNAH VEGF165 Human,
Cynomolgus
Active Native
63004-ZNAB VEGF165 Danio rerio
(zebrafish)
Active Native
70004-DNAH VEGF164 Canine Active Native
80006-RNAB VEGF164 Rat Active Native
10544-H01H VEGFB Human Active hFc
80103-R01H VEGFC (aa 108-223) Mouse, Rat Active hFc
80103-R08H VEGFC (aa 108-223) Mouse, Rat Active His
50157-M01H VEGFD Mouse Active hFc
50157-M08H VEGFD Mouse Active His
80104-R01H VEGFD Rat Active hFc
10274-H05H PIGF Human Active mFc

 

More recombinant VEGF and receptor proteins

  • VEGFA
  • VEGFB
  • VEGFC
  • VEGFD
  • PIGF
  • VEGFR1/FLT-1
  • VEGFR2/KDR
  • VEGFR3/FLT-4
  • NRP1
  • NRP2

VEGF/VEGFR antibodies

Sino Biological has formulated more than 100 antibodies against VEGF and receptor proteins. These antibodies exhibit validated activities in different applications, such as ELISA, flow cytometry, immunohistochemistry, western blotting, immunofluorescence and neutralization. Sino Biological also offers ELISA kits and ELISA pair sets.

Antibody list of CSFs and CSFR

  • Anti-VEGFA
  • Anti-VEGFC
  • Anti-VEGFD
  • Anti-PIGF
  • Anti-VEGFR1/FLT-1
  • Anti-VEGFR2/KDR
  • Anti-VEGFR3/FLT-4
  • Anti-NRP1
  • Anti-NRP2

About Sino Biological Inc.

Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offers pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.

Sino Biological's core business

Sino Biological is committed to providing high-quality recombinant protein and antibody reagents and to being a one-stop technical services shop for life science researchers around the world. All of our products are independently developed and produced. In addition, we offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates. Our product quality control indicators meet rigorous requirements for clinical use samples. It takes only a few weeks for us to produce 1 to 30 grams of purified monoclonal antibody from gene sequencing.


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Last updated: Sep 24, 2021 at 6:28 AM

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