Head and neck cancer (HNC) is a heterogeneous disease affecting multiple sites and cellular origins of the head and neck, including the paranasal sinuses, nasal cavity, tongue, oral cavity, larynx, pharynx, and salivary glands.
It accounts for 4% of all cancer cases in the United States and is the sixth deadliest cancer in the world. Early detection is essential for enhancing treatment outcomes, emphasizing the importance of developing new diagnostics and therapeutics.
Aside from proven biomarkers, such as MMP9, EGFR, CDKN2A, and VEGF, emerging biomarkers and drug targets like CXCR4/CD184, cIAP1, KLK6, FGFR1, XIAP, Osteonectin, BCL-2, S100A9, c-MET, FGFR3, CD44, Alpha-fetoprotein, IL-8/CXCL8, Beta-Tubulin, PFN1, and cyclin D1 provide innovative opportunities for the development of treatments options.
Sino Biological provides high-quality antibodies, recombinant proteins, and ELISA kits to assist head and neck cancer research.
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849129242717166.png)
Figure 1. Emerging biomarkers in head and neck cancer. Image Credit: Sino Biological Inc.
Featured recombinant HNC biomarker proteins
Sino Biological provides high-quality recombinant proteins to assist head and neck cancer research.
- High-purity
- Activity-validated
- Low-endotoxin
- Cited by researchers
Human S100A9 protein (Cat#: 11145-H08B)
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849129476733117.png)
Immobilized S100A8 protein can bind to human S100A9 protein. Image Credit: Sino Biological Inc.
Human BCL-2 protein (Cat#: 10195-H08E)
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849129597054040.png)
Immobilized human BCL2 protein can bind Mouse BCL2L1 protein (Cat#: 50012-M08E). Image Credit: Sino Biological Inc.
Human FGFR3 protein (Cat#: 16486-H02H)
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849129794651898.png)
Ability to inhibit FGF-acidic-dependent proliferation of Balb/c 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.
Human FGFR1 protein (Cat#: 10616-H08H)
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_1684913024968889.png)
Ability to inhibit FGF acidic-dependent proliferation of Balb/C 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.
Human CXCR4/CD184 protein (Cat#: 11325-HNAH) HPLC verified
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849130400945533.png)
Immobilized human CXCR4/CD184 protein-VLP can bind anti-human CXCR4/CD184 Antibody. Image Credit: Sino Biological Inc.
Human IL-8/CXCL8 protein (Cat#: 10098-HNCH2)
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849130520478226.png)
Immobilized human IL-8/CXCL8 can bind anti-IL-8/CXCL8 antibody (Cat#: 10098-MM18). Image Credit: Sino Biological Inc.
More recombinant HNC biomarker proteins (partial)
Table 1. Source: Sino Biological Inc.
Cat# |
Proteins |
Species |
Expression Host |
Purity |
Activity |
Tag |
10929-H08H
2 Citations
|
Osteonectin |
Human |
HEK293 Cells |
> 98 % |
Active |
His |
50494-M08H
1 Citation
|
Mouse |
HEK293 Cells |
> 96 % |
Active |
His |
80870-R08H |
Rat |
HEK293 Cells |
> 90 % |
Active |
His |
11145-HNAE
3 Citations
|
S100A9 |
Human |
E. coli |
> 95 % |
|
Native |
50284-M07E
2 Citations
|
Mouse |
E. coli |
> 95 % |
|
Native |
16482-H02H |
FGFR1 |
Human |
HEK293 Cells |
> 90 % |
Active |
hFc |
10616-H20B1 |
Human |
Baculovirus-Insect Cells |
> 80 % |
|
His & GST |
16044-H02H
1 Citation
|
FGFR3 |
Human |
HEK293 Cells |
> 95 % |
Active |
hFc |
50071-M03H |
Mouse |
HEK293 Cells |
> 92 % |
Active |
His & hFc |
90313-C02H
1 Citation
|
Cynomolgus |
HEK293 Cells |
> 90 % |
Active |
hFc |
10195-H08E1 |
BCL-2 |
Human |
E. coli |
> 90 % |
|
Native |
10692-H27H-B
2 Citations
|
c-MET |
Human |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
Active |
His & AVI |
10692-H20B1 |
Human |
Baculovirus-Insect Cells |
> 90 % |
Active |
His & GST |
50622-M02H
11 Citations
|
Mouse |
HEK293 Cells |
> 92 % |
Active |
hFc |
80004-R02H |
Rat |
HEK293 Cells |
> 95 % |
Active |
hFc |
90304-C08H |
Cynomolgus, Rhesus |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
Active |
His |
12211-H02H
7 Citations
|
CD44 |
Human |
HEK293 Cells |
> 90 % |
|
hFc |
12211-HNAH |
Human |
HEK293 Cells |
> 95 % (SEC-HPLC) |
|
Native |
10098-H01H1
5 Citations
|
IL-8/CXCL8 |
Human |
HEK293 Cells |
> 95 % |
Active |
hFc |
10098-H08Y
2 Citations
|
Human |
Yeast |
> 95 % |
Active |
His |
11090-H17E
1 Citation
|
cIAP1 |
Human |
E. coli |
> 92 % |
Active |
AVI |
12142-H08H |
KLK6 |
Human |
HEK293 Cells |
> 95 % |
|
His |
10606-H17E |
XIAP |
Human |
E. coli |
> 75 % |
Active |
AVI |
10606-H07E1
1 Citation
|
Human |
E. coli |
> 95 % |
|
His |
12177-H02H
7 Citations
|
α-fetoprotein |
Human |
HEK293 Cells |
> 90 % |
|
hFc |
12177-H08H |
Human |
HEK293 Cells |
≥ 90 % (SEC-HPLC) |
|
His |
10001-H08H
11 Citations
|
EGFR |
Human |
HEK293 Cells |
> 90 % (SEC-HPLC) |
Active |
His |
10001-H27H-B |
Human |
HEK293 Cells |
> 95 % (SEC-HPLC) |
Active |
His & AVI |
29662-H02B
1 Citation
|
Human |
Baculovirus-Insect Cells |
> 95 % |
Active |
hFc |
51091-M02H |
Mouse |
HEK293 Cells |
> 90 % |
Active |
hFc |
51091-M08H
2 Citations
|
Mouse |
HEK293 Cells |
> 85 % (SEC-HPLC) |
Active |
His |
70026-D08B |
Canine |
Baculovirus-Insect Cells |
> 90 % |
Active |
His |
80100-R08H
2 Citations
|
Rat |
HEK293 Cells |
> 98 % |
Active |
His |
90285-C08H |
Cynomolgus |
HEK293 Cells |
> 90 % (SEC-HPLC) |
Active |
His |
90317-K02H
6 Citations
|
Rhesus |
HEK293 Cells |
> 95 % |
Active |
hFc |
10008-HNAH
1 Citation
|
VEGF |
Human |
HEK293 Cells |
> 95 % (SEC-HPLC) |
Active |
Native |
10009-HNAB
2 Citations
|
Human |
Baculovirus-Insect Cells |
> 95 % |
Active |
Native |
11066-H27H-B
13 Citations
|
Human, Cynomolgus |
HEK293 Cells |
> 95 % |
Active |
His & AVI |
50159-MNAB
7 Citations
|
Mouse |
Baculovirus-Insect Cells |
> 90 % |
Active |
Native |
70004-DNAH
1 Citation
|
Canine |
HEK293 Cells |
> 95 % |
Active |
Native |
80006-RNAB
2 Citations
|
Rat |
Baculovirus-Insect Cells |
> 86 % |
Active |
Native |
10327-H08H
4 Citations
|
MMP-9 |
Human |
HEK293 Cells |
> 90 % |
Active |
His |
50560-MNAH
2 Citations
|
Mouse |
HEK293 Cells |
> 85 % |
|
Native |
80049-R08H
5 Citations
|
Rat |
HEK293 Cells |
> 85 % |
Active |
Native |
Featured antibodies against HNC biomarkers
Sino Biological has created a panel of antibodies with multiple applications, including ELISA, ICC/IF, IHC-P, FCM, IP, and WB, to assist head and neck cancer research.
Anti-PFN1 antibody
- Cat#: 107394-T40
- Type: Rabbit PAb
- Ig Type: Rabbit IgG
- Applications: WB, IHC-P
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849130702632784.jpg)
Immunochemical staining of PFN1 in mouse colon. Image Credit: Sino Biological Inc.
Beta-Tubulin loading control antibody
- Cat#: 100109-MM05T
- Type: Mouse MAb
- Ig Type: Mouse IgG2b
- Applications: WB, IHC-P, IP, ICC/IF
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_1684913118655664.jpg)
Immunofluorescence staining of human Beta-Tubulin in HeLa cells. Image Credit: Sino Biological Inc.
Anti-c-MET antibody (PE)
- Cat#: 10692-R243-P
- Type: Rabbit MAb
- Ig Type: Rabbit IgG
- Applications: FCM
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849131350235392.jpg)
Profile of anti-human C-Met reactivity on HepG2 cells analyzed by flow cytometry. Image Credit: Sino Biological Inc.
CD44 matched ELISA antibody pair set
- Cat#: SEK12211
- Applications: Sandwich ELISA
![Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more](https://d2jx2rerrg6sh3.cloudfront.net/images/equipments/ImageForEquipment_6716_16849131504873602.jpg)
Determination of the CD44 concentration. Image Credit: Sino Biological Inc.
More featured antibodies against HNC biomarkers (partial)
Table 2. Source: Sino Biological Inc.
Cat# |
Antigen |
Species |
Clonality |
Ig Type |
Application |
10929-RP02 |
Osteonectin |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
10929-MM14 |
Human |
Mouse MAb |
Mouse IgG1 |
ELISA |
50494-R001
2 Citations
|
Mouse |
Rabbit MAb |
Rabbit IgG |
WB, ELISA, IP |
11145-R018
1 Citation
|
S100A9 |
Human |
Rabbit MAb |
Rabbit IgG |
WB, ELISA |
11145-R209 |
Human |
Rabbit MAb |
Rabbit IgG |
IHC-P |
11145-RP02 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
11145-MM01
1 Citation
|
Human |
Mouse MAb |
Mouse IgG2b |
FCM, ICC/IF |
100621-T08 |
FGFR1 |
Human |
Rabbit PAb |
Rabbit IgG |
IHC-P |
10616-MM09 |
Human |
Mouse MAb |
Mouse IgG2a |
IHC-P |
50186-R001 |
Mouse |
Rabbit MAb |
Rabbit IgG |
ELISA |
105806-T08 |
FGFR3 |
Mouse |
Rabbit PAb |
Rabbit IgG |
IHC-P |
100550-MM07 |
Human |
Mouse MAb |
Mouse IgG1 |
IHC-P |
50071-RP01 |
Mouse |
Rabbit MAb |
Rabbit IgG |
ELISA |
100126-R204 |
BCL-2 |
Human |
Rabbit MAb |
Rabbit IgG |
IHC-P, FCM |
10195-T16
2 Citations
|
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
10195-MM17 |
Human |
Mouse MAb |
Mouse IgG1 |
WB, IHC-P |
10692-R243
1 Citation
|
c-MET |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA, FCM |
100352-T32 |
Human |
Rabbit PAb |
Rabbit IgG |
WB |
10692-MM02
2 Citations
|
Human |
Mouse MAb |
Mouse IgG1 |
ELISA |
12211-R001 |
CD44 |
Human |
Rabbit MAb |
Rabbit IgG |
ICC/IF |
12211-T62 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA, IHC-P, ICC/IF, IP |
12211-MM01
4 Citations
|
Human |
Mouse MAb |
Mouse IgG1 |
WB, ELISA, IHC-P, IP |
12211-MM02
1 Citation
|
Human |
Mouse MAb |
Mouse IgG1 |
FCM, ICC/IF |
310268-T36 |
CXCR4 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, IP |
10098-MM18 |
IL-8/CXCL8 |
Human |
Mouse MAb |
Mouse IgG1 |
ELISA, ELISA (Det) |
201528-T42 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, IHC-P, ICC/IF |
90280-R009
1 Citation
|
Rhesus |
Rabbit MAb |
Rabbit IgG |
ELISA |
201591-T02 |
cIAP1 |
Human |
Rabbit PAb |
Rabbit IgG |
ICC/IF |
50255-T48 |
KLK6 |
Mouse |
Rabbit PAb |
Rabbit IgG |
WB, ELISA |
10606-T26 |
XIAP |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P, ICC/IF |
310830-T34 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ICC/IF |
12177-R003 |
α-fetoprotein |
Human |
Rabbit MAb |
Rabbit IgG |
WB, ELISA, IP |
12177-RP01
1 Citation
|
Human |
Rabbit PAb |
Rabbit IgG |
ELISA |
12177-MM35T-A |
Human |
Mouse MAb |
Mouse IgG1 |
FCM |
12177-MM33
1 Citation
|
Human |
Mouse MAb |
Mouse IgG1 |
ELISA |
104782-T34 |
PFN1 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ICC/IF |
207508-T36
2 Citations
|
cyclin D1 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, IP |
10204-R032 |
E-Cadherin |
Human |
Rabbit MAb |
Rabbit IgG |
IHC-P, ICC/IF |
10204-T58 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA, IHC-P, ICC/IF |
10204-MM04
7 Citations
|
Human |
Mouse MAb |
Mouse IgG1 |
ELISA (Cap), ICC/IF |
10001-R021
4 Citations
|
EGFR |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA, ELISA (Det), ICC/IF |
10001-RE01-F |
Human |
Rabbit MAb |
Rabbit IgG |
FCM |
10001-REN01 |
Human |
Rabbit MAb |
Rabbit IgG |
Neutralization |
10001-T48 |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ELISA |
10001-T24 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
10001-MM01
1 Citation
|
Human |
Mouse MAb |
Mouse IgG2b |
ELISA |
10001-MM08T |
Human |
Mouse MAb |
Mouse IgG1 |
FCM, ICC/IF |
10001-MM11 |
Human |
Mouse MAb |
Mouse IgG1 |
IHC-P |
11066-R010
5 Citations
|
VEGF |
Human, Cynomolgus |
Rabbit MAb |
Rabbit IgG |
Neutralization |
11066-R105
1 Citation
|
Human, Cynomolgus |
Rabbit MAb |
Rabbit IgG |
ELISA |
10008-T26 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P, ICC/IF |
101465-MM02
1 Citation
|
Human |
Mouse MAb |
Mouse IgG3 |
IHC-P |
10011-MM01
1 Citation
|
Human |
Mouse MAb |
Mouse IgG1 |
FCM |
10327-R043
1 Citation
|
MMP-9 |
Human |
Rabbit MAb |
Rabbit IgG |
ELISA (Det) |
10327-T24 |
Human |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
10327-MM01
5 Citations
|
Human |
Mouse MAb |
Mouse IgG1 |
ELISA |
101169-T38 |
CDKN2A |
Human |
Rabbit PAb |
Rabbit IgG |
WB, ICC/IF, IP |