Acclaim Mixed-Mode WCX-1 LC Column from Thermo Scientific

The Acclaim® Mixed-Mode WCX-1 is a novel, high-efficiency, silica-based column, manufactured by bonding a specially designed proprietary ligand with both hydrophobic and weak cation-exchange properties. Selectivity of ionizable and neutral compounds can be controlled independently or simultaneously by tuning mobile phase ionic strength, pH or organic modifier. This column therefore can separate using multiple separation modes: reversed phase, cation exchange, and normal phase/HILIC.

  • Adjustable selectivity
  • Ideal selectivity for separating basic molecules
  • Selectivity complementary to RP columns
  • Multimode separation mechanism: RP, Cation-exchange, Ion-exclusion and HILIC
  • Capable of separating a mixture of neutral and basic compounds

The adjustable selectivity of the Mixed-Mode WCX-1 makes it an ideal column for secondary methods development since the selectivity is orthogonal to C18 columns and weak anion-exchange (WAX) columns.

The Acclaim Mixed-Mode WCX-1 columns novel column chemistry offers multiple retention mechanisms, including RPLC, cation-exchange, ion-exclusion and HILIC. This feature makes this column versatile in many applications that require different selectivities.