Advanced flow cytometry for next-level functional antibody analysis

Flow cytometry is a widely utilized technique for measuring and counting cells,1 offering sophisticated analysis capabilities for various physical properties of cells and antibodies.

Image Credit: Sartorius 

In recent years, antibodies have become an incredibly popular therapeutic target – with monoclonal antibodies (mAbs) becoming an ever more widely used therapy for a number of diseases, including cancers and COVID-19.2

One of the current challenges around mAbs and functional antibody-based treatments is the relatively high costs associated with the research and production of new therapeutics.

Advanced flow cytometry significantly speeds up the screening of new therapies by identifying the action mechanisms of antibodies. This includes determining if an antibody must form a conjugate with a drug to acquire cytotoxic properties against cancer cells. Enhancing the efficiency of identifying therapeutic potentials is thus crucial in lowering the development costs of new antibodies.

iQue® Advanced Flow Cytometry Platform

While flow cytometry is a beneficial technique for screening potential new therapeutics, particularly in combination with enzyme-linked immunosorbent assays (ELISA) and microscopy, these workflows are labor-intensive and unsuitable for throughput intensification.

The iQue® Advanced Flow Cytometry Platform, however, can bring all of the benefits of multiplex parameter analysis in a single sample well for the acceleration of antibody research and development.

At the heart of Sartorius’ new instrumentation is the power of miniaturization and automation. Designed with reduced sample consumption and automation of workflows in mind, the iQue® Advanced Flow Cytometry Platform is suitable for a number of different analysis types, including cell monitoring and workflows, cytokines profiling, and cell health and proliferation analysis.

The automation and efficiency gains extend to experiment workflows and data analysis and visualization, including advanced rapid data visualization and interpretation software to combat many of the typical bottlenecks in the data analysis process.

Sartorius has produced a poster collection detailing a number of examples of next-level functional antibody analysis, which also showcases and details the range of analysis methods offered by the new iQue® Advanced Flow Cytometry Platform.

Download this poster collection to find out how Sartorius’ new advanced platform could accelerate your antibody analysis and development with advanced automation for next-level functional antibody analysis.  

Download the white paper to learn more

References and further reading

  1. Adan, A., Alizada, G., Kiraz, Y., Baran, Y., & Nalbant, A. (2017). Flow cytometry: basic principles and applications. Critical Reviews in Biotechnology, 37(2), 163–176. https://doi.org/10.3109/07388551.2015.1128876
  2. Samaranayake, H., Wirth, T., Schenkwein, D., Räty, J. K., & Ylä-Herttuala, S. (2009). Challenges in monoclonal antibody-based therapies. Annals of Medicine, 41(5), 322–331. https://doi.org/10.1080/07853890802698842

About Sartorius

Sartorius

Sartorius is a leading international pharmaceutical and laboratory equipment supplier. With our innovative products and services, we are helping our customers across the entire globe to implement their complex and quality-critical biomanufacturing and laboratory processes reliably and economically.

The Group companies are united under the roof of Sartorius AG, which is listed on the Frankfurt Stock Exchange and holds the majority stake in Sartorius Stedim Biotech S.A. Quoted on the Paris Stock Exchange, this subgroup is comprised mainly of the Bioprocess Solutions Division.

Innovative technologies enable medical progress

A growing number of medications are biopharmaceuticals. These are produced using living cells in complex, lengthy and expensive procedures. The Bioprocess Solutions Division provides the essential products and technologies to accomplish this.

In fact, Sartorius has been pioneering and setting the standards for single-use products that are currently used throughout all biopharmaceutical manufacturing processes.

Making lab life easier

Lab work is complex and demanding: Despite repetitive analytical routines, lab staff must perform each step in a highly concentrated and careful way for accurate results.

The Lab Products and Services Division helps lab personnel excel because its products, such as laboratory balances, pipettes and lab consumables, minimize human error, simplify workflows and reduce physical workloads


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Last updated: Nov 27, 2023 at 7:45 AM

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