Life Science On-Demand Webinars
Featured Life Science Webinars
Hear how researchers are leveraging Simple Plex assays on Ella to monitor the cellular immune response in real time. Ella enables the rapid and high quality cytokine and pro-inflammatory biomarker monitoring in support of disease severity and progression research in a multi-analyte, automated and standardized format.
In this webinar, Dr. Jason Otterstrom and Dr. Alexandra Lubin will describe the AI-powered analysis platform their teams have developed, highlighting a range of applications validating its performance. In brief, the easy-to-use software automatically identifies the Zebrafish outline, and internal anatomy & body regions with no required user inputs.
In recent years, non-destructive 3D imaging techniques such as micro-computed tomography (microCT) have increasingly captured the attention of preclinical researchers across almost every discipline.
Orthodontic departments continually adapt and refine clinical SOPs for improving patient care across a wide range of clinical solutions, all of which benefit from high-resolution non-destructive 3D data.
COVID-19 is a global pandemic caused by the SARS-CoV-2 virus. There is a huge worldwide effort underway to discover vaccines and new drugs, and to repurpose old drugs to treat this disease.
The ability to quantitate lung disease and monitor disease development and resolution in real time is an advantage to using small animal microCT.
Polysaccharide-protein conjugate vaccines are among the safest and most successful vaccines developed during the last 30 years.
Image reconstruction is a fundamental part of PET allowing to generate 3D tomographic images of the tracer’s spatial distribution based on the position and timing of the detected annihilation gammas.
Hyperpolarized 129Xe MRI has emerged as a powerful technique to evaluate lung function and has found clinical application in several disorders like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and more.
For over 45 years, Sutter Instrument has designed and produced electro-mechanical and optical instrumentation that helps scientists push the limits.
Scientists can now interrogate cellular biology and cell-to-cell interactions in previously unachievable ways, gaining deeper insight and advancing innovative strategies for targeting cancer.
Sutter Instrument’s new line of amplifier systems are quickly becoming the solution of choice in the research community. At this free webinar on April 7, 2020, we demonstrated useful techniques, and tips that showcased some of our newest features, such as dynamic clamp capability.
Deriving deeper biological insight & improving productivity in immune-cell biology
A growing body of evidence suggests that more relevant, translational observations can be made using 3D microtissues and organoids as compared to 2D monolayer cell culture.
How the use of enhanced data analytics and cell models, has led to the evolution of the IncuCyte® real-time immune cell killing application.
Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging.
Cell migration and invasion processes play a role in many normal and pathological cellular processes. One of these pathological processes is tumor metastasis. In vitro assays are an excellent way to study both 2D and 3D cell movements to help you better understand cancer cell metastasis.
Biomedical researchers are increasingly using advanced human cell models for translational biology and therapeutic discovery studies.
Monoclonal antibodies (mAb) and antibody-drug conjugates (ADCs) are widely used biological therapeutics.
Our new cell-by-cell analysis module allows users to ‘count and classify’ heterogeneity in cell populations over time.
RAS GTPases are prototypical members of the RAS protein superfamily and regulate a diverse range of cytoplasmic signaling networks.
Mechanical stress, stretching of muscles or shear stress in blood vessels and kidneys for example, is important to the physiological functioning of many organs.
Stem cell therapies begin to enter the clinic, and their quality and safety depends on raw materials used in their production.
Targeted Protein Degradation refers to the use of bifunctional small molecule Degraders, such as PROTACs, to achieve proteasomal degradation.
The expedited schemes available from global regulatory bodies offer significant advantages for drug product developers. While the basic tenants of quality, safety and efficacy testing remain, such programs have been introduced to rapidly get cutting edge treatments to target patient populations.
When it comes to study design in research, specific considerations are required when designing programs of work which aim to assess the safety of viral products.
Salt is an essential ingredient of processed food. The salt content often needs to be determined as accurately as possible, as salt not only influences the taste, but also health.
In this on demand webinar we explain the basics of a widely used analytical technique. Titration is one of the most frequently used techniques in quantitative analysis, its use ranging across various industries.
The analysis of water is crucial in many areas; waste treatment, water bottling operations, environmental studies and more. This presentation outlines the basic chemistry of water and the mechanics of key analyses such as pH, BOD, COD, alkalinity, hardness, etc…
In order to use the result of a chemical analysis for other purposes, its quality must be assessed. One important quality feature is the probability that the result coincides with the ‘true’ value. It is obtained by the evaluation of the measurement uncertainty.
The surfactant content of chemicals involved in different process steps, lubricants, raw materials or finished products is crucial for quality assurance. It can easily be determined by titration if certain conditions are fulfilled.
However your titration tasks are executed at the moment there is always room for improvement. Automation of different steps involved in a titrimetric analysis not only saves time and money, but also makes the analysis operator-independent and significantly enhances accuracy and precision.
How recombinant human albumin can increase cell viability and provide consistent performance
Micro-computed tomography (micro-CT) offers significant advantages over other X-ray imaging techniques in the field of bone research.
The World Health Organization has listed stroke as the second most common cause of death world-wide.
Endodontics is a specialty within the field of dentistry concerned with the morphology, physiology and pathology of the human dental pulp and periradicular tissues.
In this presentation, Bruker Daltonics shows how PASEF, implemented on the Bruker timsTOF Pro, can be applied to HCP analysis.
Presented by our senior imaging scientist Simon Renshaw, this on-demand webinar gives you hands-on advice on how to optimize IHC and ICC experiments.
Listen in as Dr Elizabeth Glennon, of King's College London, discusses how the disruption of axonal transports early on within Alzheimer's Disease provides excellent targets for drug discovery.
Review striking similarities between the operating mechanisms of EMT and carcinoma with leading expert, Professor Jean Paul Thierry.
Tumor-associated enzymes can diminish or even negate the immune system’s ability to fight off cancerous cells by making subtle but damaging structural changes to anti-cancer antibodies.
This webinar descibes how NMR is an excellent technique for verifying the authenticity and how Bruker's Honey Profiling method and its underlying database offers a fast and comprehensive honey screening solution.
Cardiovascular disease due to atherosclerosis is the leading cause of disease and mortality worldwide. So-called “vulnerable” atherosclerotic plaques are those that are likely to result in clinical events.
Pollution is a major toxic environmental hazard affecting people health, and participating in processes resulting in the formation of free radicals.
Andrew Niles, an Applications Scientist from BMG LABTECH talked at SLAS 2017 about how to perform real-time, walk-away, cell-health assays.
Kinetic Characterization of Covalent Inhibitors on the PHERAstar
Receptor function is multifaceted and it is therefore highly advantageous to monitor multiple aspects in live cells and in real-time.
The speakers show the impact that working under physiological conditions can have to improve the interpretation of data.
A TR-FRET approach to measuring the kinetics of ligand-receptor binding and its application of fragment screening
Bioluminescence resonance energy transfer has been long established as a principal method to monitor dynamic protein-protein interactions in living cells.
Steve Trim from Venomtech Ltd. presents "Novel haemoglobin modifying activity discovered through screening T-VDAcv" at the 2013 ELRIG in Manchester.
Davin M. Henderson and Carl Peters (BMG LABTECH) talked about how to optimize sensitivity and specifity in the RT- QUiC assay using BMG LABTECH plate readers.
Real-Time Cell Health Assays Deliver Better Data with Less Effort
Shanne Tillo, Carl Peters and EJ Dell, talked at SLAS 2017 about the real time detection of G-protein coupled receptors in living cells.
Optimizing the receptor binding kinetics of new drugs can have significant benefits, including improved action duration and enhanced efficacy.
Understanding how a better analysis of metabolites in serum and urine can help. Quantification in body fluids like plasma/serum and urine is valuable because it provides information on endogenous compounds produced in the body as well as capturing drugs and their metabolites, In addition lifestyle based molecules can be recognized, be it from nutritional habits or physical activity.
The webinar will update on latest developments in MALDI mass spectrometry for high-throughput screening and CPD profiling (rapifleX MALDI PharmaPulse) and introduce Bruker's new surface plasmon resonance (SPR) instrument, the SIERRA SPR-32.
We are pleased to present, “GET THE MOST FROM PRE-DURING-POST” an exclusive webinar for Pittcon exhibitors and booth staff addressing pre, during and post-show marketing.
Stakeholder Expectation and Your Objectives
Social media platforms have come a long way in the past 5 years in efforts to be more business-user friendly. It’s not just a space for individuals on their free time anymore, it’s the new way for businesses to stay in front of their customers and engage with them on a more personal level.
Social media is a brilliant tool you can use to engage your conference audience.
Many demos fail because they are not properly implemented, learn how to create and execute successful, dynamic demos in your exhibits.
Introduction of the first amplifier in the new family of patch clamp products, and the SutterPatch Software that comes bundled with the system.
We provide step-by-step guidance to the new experimenter as well as advanced tips and tricks for the experienced user.
We will be providing step-by-step guidance to the new experimenter as well as advanced tips and tricks for the experienced user.
The presentation highlights: Relevant Applications, Development of the Sutter MOM and Advanced Techniques and the Future.
This presentation will give examples which highlight the need for ensuring sample quality and observing good experimental practices for the generation of meaningful and reliable binding data.
Applications of proteomics to cell biology and biomedical research require further developments of mass spectrometry (MS) technology to overcome long-standing limitations in speed, sensitivity and robustness.
Electron Paramagnetic Resonance (EPR) spectroscopy (also known as Electron Spin Resonance - ESR), is much less well known than some of the other spectroscopy methods, and there are many misconceptions about its size, cost and complexity.
Quantification of components in solid mixtures like formulated materials is crucial in material sciences. Especially in the pharmaceutical industry, API (Active Pharmaceutical Ingredient) form quantification plays a central role from early drug development to manufacturing. The new benchtop solution the minispec Form Check offers an easy and non-destructive way to determine the ratio of either different drug components or various solid forms in a substance.
In this webinar, Professor Greetje Vande Velde will give an overview of her work, which involves lung and brain infections. Professor Vande Velde will describe how high-field MRI and low dose microCT complement each other; where microCT gives high contrast in the lungs and MRI allows clear visualization of the brain.
EPR can be a powerful method, both for academic research and as a teaching tool in undergraduate laboratory classes.
In this webinar, Dr. Dane Maxfield discusses the benefits of light-sheet fluorescence microscopy as a gentle bio-imaging technique for imaging a wide range of biological samples with high spatial and temporal resolution
Mass spectrometry imaging produces highly complex data that is difficult to access and understand. This webinar demonstrates feature extraction with principal components and advanced visualization techniques in SCiLS Lab
Learn long-term live cell imaging for high-content applications & learn about the new developments in image acquisition that combine live cell incubation and imaging with high-content screening approaches.
For the body to defend and fight against cancer, immune cells must recognize, engage, destroy and ultimately remove unwanted tumor cells. Understanding these processes at the cellular level is central to identifying and validating new immunotherapy approaches.
Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell types for novel targets. One example is the enhancement of macrophage function via inhibitors of CD47 “don’t-eat-me” signalling proteins, enabling tumour cells to evade clearance by neighbouring phagocytes (Kim et al, 2012, Leukemia 26, 2538–2545).
The most common in vitro methods for immunologists to analyze cells of the immune system are flow cytometry, PCR and various forms of ELISA. Together, these enable quantification of different cell populations at the molecular and functional level (‘immuno-phenotyping’) and measurement of immune responses, for example, cytokine release.
In this exclusive webcast of our workshop held at IMMUNOLOGY 2017™ in Washington, D.C., learn how to add real-time visualization and analysis of immune cell cultures to your in vitro assay toolkit for immunology research.
The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells initiate immune escape is less understood.
The last decade has seen a significant shift in the way that mammalian cells are used in biomedical science. Researchers are increasingly turning from simple, reductionist recombinant cells to primary cells, stem-cell derived cells and advanced in vitro co-culture and organoid models for greater translation and wider application in their work.
Surface enhanced Raman scattering (SERS) is an analytical technique with several advantages over competitive techniques in terms of improved sensitivity and multiplexing.
Diagnostic epigenetic loci are typically located using whole genome array studies which are then followed by quantitative pyrosequencing.
In this lecture, Dr Hell will discuss the simple yet powerful principles that allow neutralizing the limiting role of diffraction.
In this video, Sam Nugen gives his presentation at Pittcon 2018 titled "Designing First Generation Nanobots for Food Safety via Phage Engineering":
Analysis of cannabinoids is critical to the cannabis industry for product labeling and because product value is often based primarily on potency values. Although no standardized method exists, liquid chromatography with ultraviolet detection, LC-UV, has become the most popular technique. There is concern potency values are not consistent among labs even when the same technique is used. Methods typically consist of a simple extraction and dilution before LC-UV analysis.
Malfunctions of the brain's serotonin system are thought to underlie the symptoms of depression, primarily because antidepressants that target the serotonin transporters show some clinical success.
Electron Paramagnetic Resonance (EPR) spectroscopy is a form of magnetic resonance spectroscopy (MRS) that can be used to non-invasively detect impurities involved in the degradation of pharmaceutical properties.
Getting a good microCT image of your animal’s bone, in vivo or ex vivo, is just the start. To realize the goals of your preclinical study, quantitative outcomes are needed.
Mechanistic understanding allows informed control and optimization of reactions, so that by-products can be reduced, yields increased and reaction selectivity improved.
Raman microspectroscopy combined with advanced statistics is uniquely suitable for characterizing microheterogeneous samples. Understanding the structure and (bio)chemical composition of samples at the microscopic level is important for many practical applications including material science, pharmaceutical industry, etc.
The researchers will discuss the use of rabiolabeled siderophores in the detection of Aspergillus fumigatus, a fungus that causes the life-threatening infection invasive aspergillosis (IA). Early and accurate detection of Aspergillus infection is crucial, but current methods lack sufficient specificity and/or sensitivity.
The webinar provides a detailed overview of how high-resolution mass spectrometry and data acquisition using a 'catch all compound' acquisition scan mode can reduce instances of reporting false positives and negatives.
This webinar will introduce a technique called 2D heteronuclear single quantum coherence (HSQC) NMR spectroscopy for assessing the quality control of a biologic. Currently, this is achieved using 1D NMR spectroscopy, following the indication of international pharmacopoeia. However, although 1D spectra can help to confirm the chemical structures of heparin products, it cannot readily identify variability in its composition between batches, which can occur due to differences in the purification me
The webinar will briefly introduce the field of forensic toxicology and focus on the use of the Toxtyper system for urine screening within this field. A special focus will be on urine sample preparation to improve time- and cost-effectiveness in the lab.
Although NMR is an advanced analytical technique, today it is used as a routine method in many small molecule labs, for identifying, verifying, proving and even elucidating chemical structures.
In ovo MRI is a preclinical imaging technique in oncology research that involves the study of chicken egg embryos and a structure called the chorioallantoic membrane (CAM). The CAM is a highly vascularized and specialized tissue that performs various functions during embryonic development. The CAM model is a simple, low-cost and highly effective tool in the study of tumor angiogenesis, tumor growth, metastasis and cancer treatment; processes that can all be non-invasively monitored using MRI. I
Amongst Bruker’s extensive range of high-performance products for pharmaceutical R&D, are two powerful technologies designed to optimize NMR analysis and ensure users get the maximum value from their instruments.
The presentation will give a current overview of label-free high-throughput MALDI TOF mass spectrometry and its use in drug discovery screening. It will explain the basics of MALDI TOF mass spectrometry and the benefits of label-free screening compared to current labeled approaches.
Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensity in nuclear magnetic resonance (NMR) studies. NMR tends to be an insensitive technique, especially when the compound of interest is not very concentrated in the sample.
The Bruker Si PET technology is the first of its kind to deliver real, homogeneous submillimetric volumetric PET resolution in all three axes in the whole field of view.
During this webinar, Fabrice and Anna will introduce you to Bruker’s newly launched PotencyMR, a solution specially designed to facilitate potency/purity determination.
Worldwide, serious concern has arisen about the increased incidence of learning and developmental disorders in children.
Combining preclinical in vivo imaging modalities offers the opportunity to synergize the strengths of each in one experiment. For example, optical imaging offers the ability to non-invasively and longitudinally track molecular and cellular events, frequently using bioluminescence or fluorescence genetic reporters.
Proteins are highly versatile macromolecules that enact a wide range of biological functions such as catalysis, regulation, communication, mechanical support, movement, and transport. At least several million unique proteins exist in the human body which are, surprisingly, encoded by only fifteen thousand genes.
Small animal pre-clinical imaging is a vital tool in the field of biomedical research, allowing the study of biological processes and potential diagnostic or therapeutic agents in living animals.
The Bruker AVANCE III HD delivered cutting-edge, sophisticated NMR performance that has been adopted by labs across the world.
Reactive oxygen and nitrogen species are involved in a vast range of major diseases including cardiovascular disease, Alzheimer’s disease, Parkinson’s disease, cancer, multiple sclerosis, autism, and infections.
In recent years, an imbalance has emerged between supply and demand in the market for honey. Pressures on bee populations have resulted in a squeeze in its availability.
In this webinar, Stefan Jehle, Ph.D. and Pavel Kessler, Ph.D. from Bruker BioSpin will outline how Bruker’s TopSpin software, together with a newly launched FBS tool, can help overcome this stumbling block by facilitating the workflow, improving efficiency and minimizing human error.
In this webinar, Dr. Julien Flament of Molecular Imaging Research Center (MIRCen, CEA), Fontenay-aux-Roses, France, will present an introduction to the theoretical background of Chemical Exchange Saturation Transfer (CEST) imaging and its potential in neurodegenerative disease research.
In vivo imaging is at the heart of preclinical research into cancer biology and treatment, with advances in technology delivering tools that are ever more powerful, accurate and easy-to-use.
Bruker’s new SkyScan 1276 in vivo microCT combines high-resolution, speed, accessibility and innovation to uphold improved in vivo scanning of small laboratory animals and biological samples in preclinical studies.
One of the major benefits of In-Vitro Diagnostic Research (IVDr) by NMR is its reproducibility and transferability, which enables researchers across the globe to exchange data based on SOPs embedded in the IVDr Platform solution.
How quantitative live-cell analysis has enabled the study of FMDV RNA replication out-with high bio-containment facilities.
TD-NMR is an indispensable analytical technique used in quality control and assurance for a wide variety of applications.
Due to its great versatility, MRI is a key tool of choice for critical preclinical research, e.g. oncology, cardiology, and neurology.
The global nutraceutical market was estimated to be $140.1 billion USD in 2010. The dietary supplement (DS) natural health product (NHP) is part of this market;
NMR is becoming an increasingly important tool for the monitoring of chemical reactions. Utilization of the inherent structural and quantitative information delivered via NMR spectroscopy can provide detailed mechanistic insights and increase process understanding.
The leading analytical tools in structural biology have traditionally been X-ray crystallography and liquid state NMR, but in recent years the role of solid state NMR has increased substantially through its ability to provide answers that neither liquids NMR nor X-ray can provide in a clear enough manner.
The global nutraceutical market was estimated to be $140.1 billion US dollars in 2010. Concerns have arisen over the increasing cases of adulterated products in the market which threaten the health of the consumer and the continual growth for the nutraceutical industry.
Glioblastome multiforme is the most common form of brain cancer and diagnosed patients have a life expectancy of less than two years. In spite of the fact that its diagnosis is very good, an appropriate treatment remains elusive.
Following the huge upsurge in interest in bringing imaging to new and wider areas of research, Bruker is not only seeking to support new multimodality approaches through its instrument portfolio, but has also completely redesigned its preclinical MRI software to offer enhanced productivity and multi-platform capability.
With the cost of health care rising rapidly due to ever increasing life expectancy and changes in life style, technologies and methods need to be developed that will enable Early prediction of disease development