The advent of an earlier unknown highly contagious respiratory pathogen in January 2020 initiated a global pandemic that is persisting today. The SARS-CoV-2 coronavirus, the causative agent of COVID-19, has surpassed 211 million infections globally within twenty months of the pandemic. Until August 2021, more than four million deaths were reported (Coronavirus Resource Center, 2021).
Since1918, the world has not been drastically affected by the emergence, spread and death toll due to a respiratory virus, which not only affected public health but also the economic status of nations and individuals.
This destructive public health emergency required a comprehensive response that needed the joint effort of biotech, pharmaceutical and academic collaborators to formulate prevention and treatment approaches for this novel disease.
The current article is a reflection of COVID-19, following probable solutions for related research, vaccine and diagnostics development.
- What was achieved in the fight against COVID-19
- What is still not known about the virus
- What ACRO offers
ACROBiosystems, as a leading life science supplier, is dedicated to helping the global COVID-19 response. The company remains determined in its mission to support researchers, developers and manufacturers with key reagents to handle the continuing public health concerns. The company has consolidated its products and services, offering a comprehensive solution for SARS-CoV-2.
This is on par with the needs of the customer in both the detection of COVID-19 and the development of vaccines and therapies. As SARS-CoV-2 continues to spread and evolve, the top priority is to offer support to quickly respond to the challenges.
More forces are mobilized to keep the circulating and evolving SARS-CoV-2 variants under surveillance and produce products targeting the Variants of Concerns (VOCs) in the timeliest manner. ACROBiosystems’ product pipeline includes widely neutralizing antibodies, multiple recombinant antigen mutants, ELISA kits harboring high sensitivity and protein-pre-coupled magnetic beads that support high-throughput applications.
Image Credit: ACROBiosystems
Recombinant antigens
- ACROBiosystems offers a collection of recombinant antigen proteins of all VOCs and other prevailing SARS-CoV-2 variants, covering crucial mutations like L452R/Q, K417N/T, E484K, N501Y and D614G on the spike protein, and R203G, G204R on the nucleocapsid protein, etc.
- Various antigens are provided, i.e., Spike Trimer, Spike RBD, S1, S2, Spike NTD and Nucleocapsid protein.
- The antigen mutants have verified high bioactivity, high purity and high stability.
- Products with multiple tags (His, Avi, Fc, mFc) are available in bulk supply.
Featured products: super stable spike trimer
- Produced on the basis of the updated sequence information retrieved from GISAID/PANGOLIN/Nextstrain database
- 6P and 2A mutations were introduced to stabilize the trimeric protein in its pre-fusion configuration and eliminate the S1/S2 furin-cleavage site, respectively
- High trimer purity (>90%) verified by SEC-MALS
- Cover mutations reported on Alpha/Beta/Gamma/Delta variants (VOCs)
- Suitable for inhibitor screening assays and serological antibody titer tests
Image Credit: ACROBiosystems
Recombinant antigens
- ACROBiosystems has selected a collection of binding antibodies, neutralizing antibodies, antibodies for diagnostic, IgG antibody isotype and HRP-secondary antibody, etc. against the variants.
- High bioactivity, high purity and high stability with verification
- Enables the development of serologic tests, therapeutic antibodies and vaccines
Featured products: Broad-spectrum neutralizing antibody (Cat. No. S1N-M122)
- Appropriate to be a positive control in inhibitor screening tests
- Neutralizes all the VOCs in the pseudovirus neutralization assay
Featured products: Anti-nucleocapsid antibody pair (Cat. No. NUN-M223/NUN-S95)
- Identifies all the prevalent nucleocapsid protein variants verified by colloidal gold-based assay
- An ideal ingredient for the development of antigen detection tools.
Image Credit: ACROBiosystems
- ACROBiosystems has created a series of ELISA kits for SARS-CoV-2 detection, including neutralizing antibody serological titer kits, antibody serological titer kits, variants inhibitor screening kits, antigen titer kits, antigen-pre-coated plates, etc.
- Highly capable, can analyze 90+ samples in two hours
- Greater sensitivity and specificity.
- Substantially increases experiment efficacy while assuring highly reproducible results.
Image Credit: ACROBiosystems
Featured products: VOCs-specific neutralizing antibody serological titer kits
Table 1. Source: ACROBiosystems
| Lineage |
Cat. No. |
| SARS-CoV-2 (U.K) Alpha | B.1.1.7 |
RAS-N028 |
| SARS-CoV-2 (South Africa) Beta | B.1.351 |
RAS-N031 |
| SARS-CoV-2 (Brazil) Gamma | P.1 |
RAS-N034 |
| SARS-CoV-2 (India) Delta | B.1.617.2 |
RAS-N040, RAS-N041 |
Pre-coupled magnetic beads
- Manufactured by coupling biotinylated antigens to streptavidin-conjugated magnetic beads
- Pre-coupled and ready to use for capturing target proteins from the sample
- Employed for capturing anti-SARS-CoV-2 antibody or ACE2 protein from the sample with greater specificity
- High yield and low non-specific binding
- Appropriate for biopanning, immunocapture, flow cytometry, etc.
- Inexpensive: reduces cut time and human effort during the experiment
Image Credit: ACROBiosystems
Featured products: VOCs-specific neutralizing antibody serological titer kits
Table 2. Source: ACROBiosystems
| Cat. No. |
Product Description |
Application |
| MBS-K001 |
SARS-CoV-2 Spike S1-coupled Magnetic Beads |
S1 protein antibody screening |
| MBS-K002 |
SARS-CoV-2 Spike RBD-coupled Magnetic Beads |
Spike protein RBD antibody screening |
| MBS-K013 |
Human ACE2-coupled Magnetic Beads |
Virus capture |
| MBS-K014 |
Human Anti-SARS-CoV-2 Spike RBD Antibody-coupled Magnetic Beads |
Virus capture |
About ACROBiosystems
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application-oriented development strategy, with a particular focus on product design, quality control, and solution-based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.
To respond to the coronavirus pandemic, ACROBiosystems has developed SARS-CoV-2 antigens specifically designed and optimized for serological test kits, including Spike-derived antigen S1, RBD, and Nucleocapsid protein. Proteins have been supplied to diagnostic companies in large quantities.
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